PDB: 928 resultsInfo pagesStatus searchChemie searchBIRD

---

9F4K	UP1 in complex with ZINC72259689 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, ~{N}-(cyclobutylmethyl)-1,3-dimethyl-pyrazole-4-carboxamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F55	UP1 in complex with Z235361315 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, ~{N}-(3-azanyl-2-methyl-phenyl)propanamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F52	UP1 in complex with Z734147462 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, [4-(methylamino)oxan-4-yl]methanol Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F4R	UP1 in complex with Z802821712 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-ethyl-6-methylpyridazin-3-amine Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F7H	UP1 in complex with Z45617795 Descriptor: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, N-(2-phenylethyl)methanesulfonamide Authors: Dunnett, L, Prischi, F. Deposit date: 2024-05-03 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F4M	UP1 in complex with Z1401276297 Descriptor: (5~{R})-7-pyrazin-2-yl-2-oxa-7-azaspiro[4.4]nonane, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-04-28 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.39 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
9F7F	UP1 in complex with Z1491353358 Descriptor: (3S)-1-(phenylsulfonyl)pyrrolidin-3-amine, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed Authors: Dunnett, L, Prischi, F. Deposit date: 2024-05-03 Release date: 2024-05-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Enhanced identification of small molecules binding to hnRNP A1 via in silico hotspot and cryptic pockets mapping coupled with X-Ray fragment screening To Be Published
2LEA	Solution structure of human SRSF2 (SC35) RRM Descriptor: Serine/arginine-rich splicing factor 2 Authors: Daubner, G.M, Clery, A, Jayne, S, Stevenin, J, Allain, F.H.-T. Deposit date: 2011-06-15 Release date: 2011-11-23 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: A syn-anti conformational difference allows SRSF2 to recognize guanines and cytosines equally well. Embo J., 31, 2012
2L41	Nab3 RRM - UCUU complex Descriptor: RNA (5'-R(P*UP*CP*UP*U)-3'), RRM domain from Nuclear polyadenylated RNA-binding protein 3 Authors: Stefl, R, Pergoli, R, Hobor, F, Kubicek, K, Zimmermann, M, Pasulka, J, Hofr, C. Deposit date: 2010-09-28 Release date: 2010-11-17 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Recognition of transcription termination signal by the nuclear polyadenylated RNA-binding (NAB) 3 protein J.Biol.Chem., 286, 2011
2LKZ	Solution structure of the second RRM domain of RBM5 Descriptor: RNA-binding protein 5 Authors: Song, Z, Wu, P, Zhang, J, Wu, J, Shi, Y. Deposit date: 2011-10-23 Release date: 2012-08-08 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets Biochemistry, 2012
2LCW	solution structure of FUS/TLS RRM domain Descriptor: RNA-binding protein FUS Authors: Liu, X, Ren, J, Niu, C, Gong, W, Feng, W. Deposit date: 2011-05-10 Release date: 2012-06-06 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: TLS-RRM is a promiscuous nucleic acid binding domain To be Published
2MKS	NMR structure of the RRM domain of RBMX from homo sapiens Descriptor: RNA-binding motif protein, X chromosome Authors: Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2014-02-14 Release date: 2014-03-12 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure of the first RRM domain of the protein RBM39 from Homo sapiens To be Published
2M70	Structural determination of the Citrus sinensis Poly(A)-Binding Protein CsPABP1 Descriptor: Poly(A)-binding protein 1 Authors: Sforca, M.L, Domingues, M.N, Zeri, A.C.M, Benedetti, C.E. Deposit date: 2013-04-16 Release date: 2014-04-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural determination of the Citrus sinensis Poly(A)-Binding Protein CsPABP1 To be Published
2MMY	Solution structure of the RNA recognition motif of human TAF15 Descriptor: TATA-binding protein-associated factor 2N Authors: Kashyap, M, Ganguly, A.K, Bhavesh, N.S. Deposit date: 2014-03-22 Release date: 2015-03-25 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural delineation of stem-loop RNA binding by human TAF15 protein Sci Rep, 5, 2015
2MJN	Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1 Descriptor: Nucleolysin TIA-1 isoform p40 Authors: Sattler, M, Wang, I. Deposit date: 2014-01-13 Release date: 2014-04-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1. Nucleic Acids Res., 42, 2014
2M8H	RRM domain of human RBM7 Descriptor: RNA-binding protein 7 Authors: Sikorsky, T, Hrossova, D, Vanacova, S, Stefl, R. Deposit date: 2013-05-21 Release date: 2015-01-28 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: RNA binding properties of the human NEXT complex To be Published
2LYV	Solution structure of the two RRM domains of hnRNP A1 (UP1) using segmental isotope labeling Descriptor: Heterogeneous nuclear ribonucleoprotein A1 Authors: Barraud, P, Allain, F.H.-T. Deposit date: 2012-09-19 Release date: 2012-12-26 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology. J.Biomol.Nmr, 55, 2013
2MHN	NMR structure of the first RRM domain of the protein RBM39 from Homo sapiens Descriptor: RNA-binding protein 39 Authors: Serrano, P, Geralt, M, Dutta, S.K, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2013-12-02 Release date: 2014-01-01 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR structure of the first RRM domain of the protein RBM39 from Homo sapiens To be Published
2MGZ	Solution structure of RBFOX family ASD-1 RRM and SUP-12 RRM in ternary complex with RNA Descriptor: Protein ASD-1, isoform a, Protein SUP-12, ... Authors: Takahashi, M, Kuwasako, K, Unzai, S, Tsuda, K, Yoshikawa, S, He, F, Kobayashi, N, Guntert, P, Shirouzu, M, Ito, T, Tanaka, A, Yokoyama, S, Hagiwara, M, Kuroyanagi, H, Muto, Y. Deposit date: 2013-11-12 Release date: 2014-08-13 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing Nat.Struct.Mol.Biol., 21, 2014
2MB0	Solution structure of hnRNP G RRM in complex with the RNA 5'-AUCAAA-3' Descriptor: RNA-binding motif protein, X chromosome, RNA_(5'-R(*AP*UP*CP*AP*AP*A)-3') Authors: Moursy, A, Allain, F.H.-T, Clery, A. Deposit date: 2013-07-22 Release date: 2014-04-09 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation. Nucleic Acids Res., 42, 2014
2MKC	Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex Descriptor: Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26, U2 snRNP component IST3 Authors: Wysoczanski, P, Schneider, C, Xiang, S, Munari, F, Trowitzsch, S, Wahl, M.C, Luhrmann, R, Becker, S, Zweckstetter, M. Deposit date: 2014-02-04 Release date: 2014-09-03 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nat.Struct.Mol.Biol., 21, 2014
2LXU	Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A Descriptor: Heterogeneous nuclear ribonucleoprotein H Authors: Ramelot, T.A, Yang, Y, Pederson, K, Shastry, R, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Prestegard, J.H, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) Deposit date: 2012-08-31 Release date: 2012-10-31 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A To be Published
2M52	NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Descriptor: Splicing factor U2AF 65 kDa subunit Authors: Dutta, S.K, Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2013-02-12 Release date: 2013-03-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR Structure of the third RNA Recognition Motif (RRM) of U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 To be Published
2M7S	NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1 Descriptor: Serine/arginine-rich splicing factor 1 Authors: Dutta, S.K, Serrano, P, Geralt, M, Wuthrich, K, Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2013-04-29 Release date: 2013-05-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1 To be Published
2M8D	Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3' Descriptor: RNA (5'-R(*UP*GP*AP*AP*GP*GP*AP*C)-3'), Serine/arginine-rich splicing factor 1 Authors: Clery, A, Sinha, R, Anczukow, O, Corrionero, A, Moursy, A, Daubner, G, Valcarcel, J, Krainer, A.R, Allain, F.H.T. Deposit date: 2013-05-17 Release date: 2013-07-10 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proc.Natl.Acad.Sci.USA, 110, 2013

<11121314151617181920212223242526>