PDB: 243531 resultsInfo pagesStatus searchChemie searchBIRD

---

5VDS	Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdUMP Descriptor: 3',3'-cdUMP, Cyclic GMP-AMP synthase, ZINC ION Authors: Byrnes, L.J, Hall, J.D. Deposit date: 2017-04-03 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.766 Å) Cite: The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci., 26, 2017
8VCG	Mutant Src SH2 domain in complex with phosphotyrosine Descriptor: Isoform 3 of Proto-oncogene tyrosine-protein kinase Src, O-PHOSPHOTYROSINE Authors: Hashem, A, Nyovanie, S, Oltean, N, Patskovska, L, Patskovsky, Y, Krogsgaard, M. Deposit date: 2023-12-14 Release date: 2025-01-29 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Engineered Mutant Src Sh2 Domain To Be Published
8VW3	Structure of the non-symmetric capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
5I9I	Crystal structure of LP_PLA2 in complex with Darapladib Descriptor: N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide, Platelet-activating factor acetylhydrolase, SULFATE ION Authors: Liu, Q.F, Xu, Y.C. Deposit date: 2016-02-20 Release date: 2016-06-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem., 59, 2016
8W3Q	Crystal structure of prefusion-stabilized hMPV F protein UFCM1-P2-iSS Descriptor: prefusion-stabilized hMPV F protein UFCM1-P2-iSS Authors: Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. Deposit date: 2024-02-22 Release date: 2025-01-15 Method: X-RAY DIFFRACTION (5.99 Å) Cite: Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus. Nat Commun, 15, 2024
7MAP	Drug Resistant HIV-1 Protease (L10I, V32I, L33F, K45I, M46I, I50V, A71V, V82I, I84V) in Complex with DRV Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Drug Resistant HIV-1 Protease (L10I, V32I, L33F, K45I, M46I, I50V, A71V, V82I, I84V) in Complex with DRV To Be Published
8VHG	Structure of the BMAL1/HIF2A heterodimer in Complex with DNA Descriptor: Basic helix-loop-helix ARNT-like protein 1, Endothelial PAS domain-containing protein 1, Forward strand DNA containing HRE motif, ... Authors: Li, T, Tsai, K.L. Deposit date: 2024-01-01 Release date: 2025-02-12 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. Nature, 641, 2025
8VTH	DUF2169 domain-containing protein from Vibrio xiamenensis Descriptor: 1,2-ETHANEDIOL, DUF2169 domain-containing protein Authors: Sachar, K, Whitney, J.C, Prehna, G, Kim, Y. Deposit date: 2024-01-26 Release date: 2025-02-12 Last modified: 2025-06-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A conserved chaperone protein is required for the formation of a noncanonical type VI secretion system spike tip complex. J.Biol.Chem., 301, 2025
5VYP	Crystal structure of the Plant Defensin NsD7 bound to PIP2 Descriptor: Defensin NsD7, GLYCEROL, SULFATE ION, ... Authors: Jarva, M, Lay, F.T, Hulett, M, Kvansakul, M. Deposit date: 2017-05-25 Release date: 2017-08-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type. FEBS Lett., 591, 2017
8VWG	Structure of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-02-01 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (4.17 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
6VUE	wild-type choline TMA lyase in complex with 1-methyl-1,2,3,6-tetrahydropyridin-3-ol Descriptor: (3S)-1-methyl-1,2,3,6-tetrahydropyridin-3-ol, Choline trimethylamine-lyase, SODIUM ION Authors: Ortega, M.A, Drennan, C.L. Deposit date: 2020-02-15 Release date: 2020-11-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. Acs Med.Chem.Lett., 11, 2020
5IGE	Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V99D at cryogenic temperature Descriptor: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease Authors: Robinson, A.C, Schlessman, J.L, Garcia-Moreno E, B. Deposit date: 2016-02-27 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V99D at cryogenic temperature To be Published
7MBH	Structure of Human Enolase 2 in complex with phosphoserine Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Gamma-enolase, ... Authors: Leonard, P.G, Hicks, K.G, Rutter, J. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science, 379, 2023
7MAQ	Drug Resistant HIV-1 Protease (L10F, V32I, L33F, K45I, A71V, V82I, I84V) in Complex with DRV Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease, SULFATE ION Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Drug Resistant HIV-1 Protease (L10F, V32I, L33F, K45I, A71V, V82I, I84V) in Complex with DRV To Be Published
6W8L	Crystal structure of JAK1 kinase with compound 10 Descriptor: N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK1 Authors: Vajdos, F.F. Deposit date: 2020-03-20 Release date: 2020-04-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg.Med.Chem., 28, 2020
8VVZ	Structure of the three-fold capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
8VVW	Structure of the five-fold capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
6WBD	Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, LYSINE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-03-26 Release date: 2020-04-08 Last modified: 2025-10-22 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine to be published
5IGP	Macrolide 2'-phosphotransferase type I - complex with GDP and erythromycin Descriptor: ERYTHROMYCIN A, GUANOSINE-5'-DIPHOSPHATE, ISOPROPYL ALCOHOL, ... Authors: Berghuis, A.M, Fong, D.H. Deposit date: 2016-02-28 Release date: 2017-04-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
8VZ6	PbAbiF dimer bound to ncRNA Descriptor: Abi family protein, AbiF ncRNA Authors: Wilkinson, M.E, Zilberzwige-Tal, S, Altae-Tran, H, Zhang, F. Deposit date: 2024-02-10 Release date: 2025-02-12 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Emergence of a CRISPR RNA-guiding mechanism from a type III toxin-antitoxin system To Be Published
5VZJ	STRUCTURE OF A TWELVE COMPONENT MPP6-NUCLEAR RNA EXOSOME COMPLEX BOUND TO RNA Descriptor: Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... Authors: Lima, C.D, Wasmuth, E.V. Deposit date: 2017-05-28 Release date: 2017-08-02 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife, 6, 2017
5IGZ	Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Macrolide 2'-phosphotransferase II, ... Authors: Berghuis, A.M, Fong, D.H. Deposit date: 2016-02-28 Release date: 2017-04-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
7MA5	HIV-1 Protease (I84V) in Complex with UMass4 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzodioxol-5-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.977 Å) Cite: HIV-1 Protease (I84V) in Complex with UMass4 To Be Published
8VYA	SARS-CoV-2 Omicron Variant Spike Glycoprotein Fusion Core (Q954H) Descriptor: SARS-CoV-2 Omicron variant spike glycoprotein C-terminal heptad repeat domain, SARS-CoV-2 Omicron variant spike glycoprotein N-terminal heptad repeat domain (Q954H) Authors: Outlaw, V.K, Apurba, R, Vithanage, N. Deposit date: 2024-02-07 Release date: 2025-02-19 Last modified: 2025-07-30 Method: X-RAY DIFFRACTION (2.12 Å) Cite: SARS-CoV-2 Omicron Variant Spike Glycoprotein Mutation Q954H Enhances Fusion Core Stability. Acs Chem.Biol., 20, 2025
5IAV	Mechanistic and Structural Analysis of Substrate Recognition and Cofactor Binding by an Unusual Bacterial Prolyl Hydroxylase - Co-BaP4H-MLI Descriptor: COBALT (II) ION, MALONATE ION, Procollagen-Proline Dioxygenase Authors: Schnicker, N.J, Dey, M. Deposit date: 2016-02-21 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns. J.Biol.Chem., 291, 2016

<170171172173174175176177178179180181182183184185>