6W8L
Crystal structure of JAK1 kinase with compound 10
Summary for 6W8L
Entry DOI | 10.2210/pdb6w8l/pdb |
Descriptor | Tyrosine-protein kinase JAK1, N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36804.88 |
Authors | Vajdos, F.F. (deposition date: 2020-03-20, release date: 2020-04-08, Last modification date: 2023-11-15) |
Primary citation | Fensome, A.,Ambler, C.M.,Arnold, E.,Banker, M.E.,Clark, J.D.,Dowty, M.E.,Efremov, I.V.,Flick, A.,Gerstenberger, B.S.,Gifford, R.S.,Gopalsamy, A.,Hegen, M.,Jussif, J.,Limburg, D.C.,Lin, T.H.,Pierce, B.S.,Sharma, R.,Trujillo, J.I.,Vajdos, F.F.,Vincent, F.,Wan, Z.K.,Xing, L.,Yang, X.,Yang, X. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg.Med.Chem., 28:115481-115481, 2020 Cited by PubMed: 32253095DOI: 10.1016/j.bmc.2020.115481 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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