6W8L
Crystal structure of JAK1 kinase with compound 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK1 | polymer | 316 | 36417.5 | 1 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
| 2 | A | N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | non-polymer | 387.4 | 1 | Chemie (R4S) | |||
| 3 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 841 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 839 | - | expression tag |
| Ser 840 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36417.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 387.4 | |
| All* | Total formula weight | 36804.9 |
