8GOB
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![BU of 8gob by Molmil](/molmil-images/mine/8gob) | Crystal Structure of Glycerol Dehydrogenase in the presence of NAD+ | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycerol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Park, T, Hoang, H.N, Kang, J.Y, Park, J, Mun, S.A, Jin, M, Yang, J, Jung, C.-H, Eom, S.H. | Deposit date: | 2022-08-24 | Release date: | 2023-06-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional insights into the flexible beta-hairpin of glycerol dehydrogenase. Febs J., 290, 2023
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8GOA
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![BU of 8goa by Molmil](/molmil-images/mine/8goa) | Crystal Structure of Glycerol Dehydrogenase in the absence of NAD+ | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycerol dehydrogenase, ZINC ION | Authors: | Park, T, Hoang, H.N, Kang, J.Y, Park, J, Mun, S.A, Jin, M, Yang, J, Jung, C.-H, Eom, S.H. | Deposit date: | 2022-08-24 | Release date: | 2023-06-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural and functional insights into the flexible beta-hairpin of glycerol dehydrogenase. Febs J., 290, 2023
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8GNN
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![BU of 8gnn by Molmil](/molmil-images/mine/8gnn) | Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex | Descriptor: | Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Cell cycle checkpoint protein RAD17, ... | Authors: | Hara, K, Nagata, K, Iida, N, Hashimoto, H. | Deposit date: | 2022-08-24 | Release date: | 2023-03-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.119 Å) | Cite: | The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. J.Biol.Chem., 299, 2023
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8GNJ
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![BU of 8gnj by Molmil](/molmil-images/mine/8gnj) | Human SARM1 bounded with NMN and Nanobody-C6, Conformation 2 | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody-C6 | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2022-08-24 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022
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8GNI
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![BU of 8gni by Molmil](/molmil-images/mine/8gni) | Human SARM1 bounded with NMN and Nanobody-C6, Conformation 1 | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1, Nanobody C6 | Authors: | Cai, Y, Zhang, H. | Deposit date: | 2022-08-24 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun, 13, 2022
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8GN9
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![BU of 8gn9 by Molmil](/molmil-images/mine/8gn9) | SPFH domain of Pyrococcus horikoshii stomatin | Descriptor: | SODIUM ION, Stomatin homolog PH1511 | Authors: | Komatsu, T, Matsui, I, Yokoyama, H. | Deposit date: | 2022-08-23 | Release date: | 2022-12-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and mutational studies suggest key residues to determine whether stomatin SPFH domains form dimers or trimers. Biochem Biophys Rep, 32, 2022
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8GN2
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![BU of 8gn2 by Molmil](/molmil-images/mine/8gn2) | Crystal structure of PPBQ-bound photosystem II complex | Descriptor: | (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Kamada, S, Nakajima, Y, Shen, J.-R. | Deposit date: | 2022-08-22 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
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8GN1
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![BU of 8gn1 by Molmil](/molmil-images/mine/8gn1) | Crystal structure of DBBQ-bound photosystem II complex | Descriptor: | (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Kamada, S, Nakajima, Y, Shen, J.-R. | Deposit date: | 2022-08-22 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
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8GN0
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![BU of 8gn0 by Molmil](/molmil-images/mine/8gn0) | Crystal structure of DCBQ-bound photosystem II complex | Descriptor: | (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | Authors: | Kamada, S, Nakajima, Y, Shen, J.-R. | Deposit date: | 2022-08-22 | Release date: | 2023-07-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
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8GMX
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8GMM
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![BU of 8gmm by Molmil](/molmil-images/mine/8gmm) | Stenotrophomonas maltophilia Holo HphA | Descriptor: | HEME B/C, Hemophilin | Authors: | Shin, H.E, Moraes, T.F. | Deposit date: | 2023-03-26 | Release date: | 2024-03-27 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Prevalence of Slam-dependent hemophilins in Gram-negative bacteria. J.Bacteriol., 206, 2024
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8GMD
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![BU of 8gmd by Molmil](/molmil-images/mine/8gmd) | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 COMPLEXED WITH (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol | Descriptor: | (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol, AP2-associated protein kinase 1, SULFATE ION | Authors: | Muckelbauer, J.K. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. Med.Chem.Res., 2023
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8GMC
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![BU of 8gmc by Molmil](/molmil-images/mine/8gmc) | CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 COMPLEXED WITH 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | Descriptor: | 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine, AP2-associated protein kinase 1, SULFATE ION | Authors: | Muckelbauer, J.K. | Deposit date: | 2023-03-24 | Release date: | 2023-07-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of pyrrolo[2,1- f ][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. Med.Chem.Res., 2023
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8GMB
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![BU of 8gmb by Molmil](/molmil-images/mine/8gmb) | Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) | Descriptor: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK | Authors: | Lin, D.Y, Andreotti, A.H. | Deposit date: | 2023-03-24 | Release date: | 2023-08-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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8GM7
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8GM6
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![BU of 8gm6 by Molmil](/molmil-images/mine/8gm6) | |
8GM5
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![BU of 8gm5 by Molmil](/molmil-images/mine/8gm5) | Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop | Descriptor: | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | Deposit date: | 2023-03-24 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J.Biol.Chem., 299, 2023
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8GM4
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![BU of 8gm4 by Molmil](/molmil-images/mine/8gm4) | Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor | Descriptor: | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | Deposit date: | 2023-03-24 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J.Biol.Chem., 299, 2023
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8GM3
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![BU of 8gm3 by Molmil](/molmil-images/mine/8gm3) | Vibrio harveyi Holo HphA | Descriptor: | HEME B/C, Hemophilin | Authors: | Pan, C, Shah, M, Moraes, T.F. | Deposit date: | 2023-03-24 | Release date: | 2024-03-27 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.727 Å) | Cite: | Prevalence of Slam-dependent hemophilins in Gram-negative bacteria. J.Bacteriol., 206, 2024
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8GLS
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![BU of 8gls by Molmil](/molmil-images/mine/8gls) | |
8GLR
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![BU of 8glr by Molmil](/molmil-images/mine/8glr) | FrlB - Deglycase for 6-phosphofructose lysine | Descriptor: | GLYCEROL, SIS domain-containing protein | Authors: | Bell, C.E, Gopalan, V, Kovvali, S. | Deposit date: | 2023-03-22 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Insights into the catalytic mechanism of a bacterial deglycase essential for utilization of fructose-lysine. Protein Sci., 32, 2023
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8GLP
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![BU of 8glp by Molmil](/molmil-images/mine/8glp) | mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. | Deposit date: | 2023-03-22 | Release date: | 2023-04-19 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (1.67 Å) | Cite: | mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
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8GLO
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![BU of 8glo by Molmil](/molmil-images/mine/8glo) | Haemophilus parainfluenzae Holo HphA | Descriptor: | CHLORIDE ION, HEME B/C, Hemophilin | Authors: | Shin, H.E, Ng, D, Moraes, T.F. | Deposit date: | 2023-03-22 | Release date: | 2024-03-27 | Last modified: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.937 Å) | Cite: | Prevalence of Slam-dependent hemophilins in Gram-negative bacteria. J.Bacteriol., 206, 2024
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8GLN
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8GLM
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![BU of 8glm by Molmil](/molmil-images/mine/8glm) | |