7CR0
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![BU of 7cr0 by Molmil](/molmil-images/mine/7cr0) | human KCNQ2 in apo state | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR3
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![BU of 7cr3 by Molmil](/molmil-images/mine/7cr3) | human KCNQ2-CaM in apo state | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR4
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![BU of 7cr4 by Molmil](/molmil-images/mine/7cr4) | human KCNQ2-CaM in complex with ztz240 | Descriptor: | Calmodulin-3, N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7E7Z
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![BU of 7e7z by Molmil](/molmil-images/mine/7e7z) | |
7E83
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![BU of 7e83 by Molmil](/molmil-images/mine/7e83) | |
7E87
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![BU of 7e87 by Molmil](/molmil-images/mine/7e87) | |
7E84
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![BU of 7e84 by Molmil](/molmil-images/mine/7e84) | CryoEM structure of human Kv4.2-KChIP1 complex | Descriptor: | Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | Authors: | Kise, Y, Nureki, O. | Deposit date: | 2021-02-28 | Release date: | 2021-10-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7E8E
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![BU of 7e8e by Molmil](/molmil-images/mine/7e8e) | |
7DXF
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![BU of 7dxf by Molmil](/molmil-images/mine/7dxf) | Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXC
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![BU of 7dxc by Molmil](/molmil-images/mine/7dxc) | Structure of TRPC3 at 3.06 angstrom in low calcium state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXG
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![BU of 7dxg by Molmil](/molmil-images/mine/7dxg) | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DXE
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![BU of 7dxe by Molmil](/molmil-images/mine/7dxe) | |
7DXB
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![BU of 7dxb by Molmil](/molmil-images/mine/7dxb) | Structure of TRPC3 at 2.7 angstrom in high calcium state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7DTC
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![BU of 7dtc by Molmil](/molmil-images/mine/7dtc) | voltage-gated sodium channel Nav1.5-E1784K | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 5 subunit alpha | Authors: | Yan, N, Pan, X, Li, Z. | Deposit date: | 2021-01-04 | Release date: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DTD
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![BU of 7dtd by Molmil](/molmil-images/mine/7dtd) | Voltage-gated sodium channel Nav1.1 and beta4 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 1 subunit alpha, ... | Authors: | Yan, N, Pan, X, Li, Z, Huang, G. | Deposit date: | 2021-01-04 | Release date: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DXD
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![BU of 7dxd by Molmil](/molmil-images/mine/7dxd) | Structure of TRPC3 at 3.9 angstrom in 1340 nM free calcium state | Descriptor: | CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-01-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7FHN
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![BU of 7fhn by Molmil](/molmil-images/mine/7fhn) | Structure of AtTPC1 D240A/D454A/E528A mutant with 1 mM Ca2+ | Descriptor: | CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHO
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![BU of 7fho by Molmil](/molmil-images/mine/7fho) | Structure of AtTPC1 D240A/D454A/E528A mutant with 50 mM Ca2+ | Descriptor: | CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHL
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![BU of 7fhl by Molmil](/molmil-images/mine/7fhl) | Structure of AtTPC1 with 50 mM Ca2+ | Descriptor: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FHK
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![BU of 7fhk by Molmil](/molmil-images/mine/7fhk) | Structure of AtTPC1 with 1 mM Ca2+ | Descriptor: | AtTPC1-Cter, CALCIUM ION, Two pore calcium channel protein 1,GFP | Authors: | Ye, F, Xu, L, Li, X, Jiang, Y, Guo, J. | Deposit date: | 2021-07-29 | Release date: | 2021-12-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Voltage-gating and cytosolic Ca 2+ activation mechanisms of Arabidopsis two-pore channel AtTPC1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7FBS
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![BU of 7fbs by Molmil](/molmil-images/mine/7fbs) | structure of a channel | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Jiang, D.J, Catterall, W.A. | Deposit date: | 2021-07-12 | Release date: | 2021-09-22 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Open-state structure and pore gating mechanism of the cardiac sodium channel. Cell, 184, 2021
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7F0J
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![BU of 7f0j by Molmil](/molmil-images/mine/7f0j) | CryoEM structure of human Kv4.2 | Descriptor: | Potassium voltage-gated channel subfamily D member 2, ZINC ION | Authors: | Kise, Y, Nureki, O. | Deposit date: | 2021-06-04 | Release date: | 2021-10-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7F3F
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![BU of 7f3f by Molmil](/molmil-images/mine/7f3f) | CryoEM structure of human Kv4.2-KChIP1 complex | Descriptor: | Isoform 2 of Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | Authors: | Kise, Y, Nureki, O. | Deposit date: | 2021-06-16 | Release date: | 2021-10-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7CR1
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![BU of 7cr1 by Molmil](/molmil-images/mine/7cr1) | human KCNQ2 in complex with ztz240 | Descriptor: | N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7D7E
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![BU of 7d7e by Molmil](/molmil-images/mine/7d7e) | Structure of PKD1L3-CTD/PKD2L1 in apo state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | Authors: | Su, Q, Chen, M, Li, B, Wang, Y, Jing, D, Zhan, X, Yu, Y, Shi, Y. | Deposit date: | 2020-10-03 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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