3GJX
 
 | | Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP | | Descriptor: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Monecke, T, Guettler, T, Neumann, P, Dickmanns, A, Goerlich, D, Ficner, R. | | Deposit date: | 2009-03-09 | | Release date: | 2009-05-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP.
Science, 2009
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1K5G
 | | Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex | | Descriptor: | ALUMINUM FLUORIDE, GTP-binding nuclear protein RAN, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R. | | Deposit date: | 2001-10-10 | | Release date: | 2002-02-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
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6KFT
 | | MVM NS2 mutant Nm42 in complex with CRM1-Ran-RanBP1 | | Descriptor: | 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... | | Authors: | Sun, Q, Li, Y. | | Deposit date: | 2019-07-08 | | Release date: | 2020-07-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
Int J Nanomedicine, 16, 2021
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6M6X
 | | Oridonin in complex with CRM1#-Ran-RanBP1 | | Descriptor: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | Authors: | Sun, Q, Lei, Y. | | Deposit date: | 2020-03-16 | | Release date: | 2021-03-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.88 Å) | | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
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6LQ9
 | | S109 in complex with CRM1-Ran-RanBP1 | | Descriptor: | (3~{R},4~{S})-1-[[6-chloranyl-5-(trifluoromethyl)pyridin-2-yl]amino]-3,4-dimethyl-pyrrolidine-2,5-dione, CHLORIDE ION, Exportin-1, ... | | Authors: | Sun, Q, Lei, Y. | | Deposit date: | 2020-01-13 | | Release date: | 2021-06-23 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.
J.Med.Chem., 64, 2021
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6M60
 | | Plumbagin in complex with CRM1#-Ran-RanBP1 | | Descriptor: | (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | Authors: | Sun, Q, Lei, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
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1GYB
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4HAU
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3A6P
 | | Crystal structure of Exportin-5:RanGTP:pre-miRNA complex | | Descriptor: | 13-mer peptide, Exportin-5, GTP-binding nuclear protein Ran, ... | | Authors: | Okada, C, Yamashita, E, Lee, S.J, Shibata, S, Katahira, J, Nakagawa, A, Yoneda, Y, Tsukihara, T. | | Deposit date: | 2009-09-07 | | Release date: | 2009-12-08 | | Last modified: | 2012-04-25 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | A high-resolution structure of the pre-microRNA nuclear export machinery
Science, 326, 2009
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4GPT
 | | Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 | | Descriptor: | 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... | | Authors: | Sun, Q, Chook, Y.M. | | Deposit date: | 2012-08-21 | | Release date: | 2012-09-05 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Leukemia, 27, 2013
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4HB0
 | | Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 | | Descriptor: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Sun, Q, Chook, Y.M. | | Deposit date: | 2012-09-27 | | Release date: | 2013-01-09 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HAX
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4HB2
 | | Crystal structure of CRM1-Ran-RanBP1 | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... | | Authors: | Sun, Q, Chook, Y.M. | | Deposit date: | 2012-09-27 | | Release date: | 2013-01-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HAV
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7YWQ
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3EBQ
 | | Crystal structure of human PPPDE1 | | Descriptor: | MERCURY (II) ION, MOLECULE: PPPDE1 (PERMUTED PAPAIN FOLD PEPTIDASES OF DSRNA VIRUSES AND EUKARYOTES 1), UPF0326 protein FAM152B | | Authors: | Walker, J.R, Akutsu, M, Qiu, L, Li, Y, Slessarev, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-08-28 | | Release date: | 2008-11-04 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of Human PPPDE1
To be Published
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3GJ0
 | | Crystal structure of human RanGDP | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Partridge, J.R, Schwartz, T.U. | | Deposit date: | 2009-03-07 | | Release date: | 2009-08-04 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Crystallographic and Biochemical Analysis of the Ran-binding Zinc Finger Domain.
J.Mol.Biol., 391, 2009
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3GJ6
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1B3U
 | | CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA | | Descriptor: | PROTEIN (PROTEIN PHOSPHATASE PP2A) | | Authors: | Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D. | | Deposit date: | 1998-12-14 | | Release date: | 1999-04-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
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2WP7
 | | Crystal structure of deSUMOylase(DUF862) | | Descriptor: | PPPDE PEPTIDASE DOMAIN-CONTAINING PROTEIN 2 | | Authors: | Kim, J.H, Woo, J.S, Oh, B.H. | | Deposit date: | 2009-08-03 | | Release date: | 2010-09-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of Desi-1, a Novel Desumoylase Belonging to a Putative Isopeptidase Superfamily.
Proteins, 80, 2012
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6CIT
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1QG2
 | | CANINE GDP-RAN R76E MUTANT | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN) | | Authors: | Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M. | | Deposit date: | 1999-04-20 | | Release date: | 1999-06-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
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8UX1
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2H4M
 | | Karyopherin Beta2/Transportin-M9NLS | | Descriptor: | Heterogeneous nuclear ribonucleoprotein A1, Transportin-1 | | Authors: | Chook, Y.M, Cansizoglu, A.E. | | Deposit date: | 2006-05-24 | | Release date: | 2006-10-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
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5CJ2
 | | Ran GDP Y39A mutant triclinic crystal form | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Vetter, I.R, Brucker, S. | | Deposit date: | 2015-07-13 | | Release date: | 2015-09-09 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy.
J.Biol.Chem., 290, 2015
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