2RVK
| |
5OQT
| |
6ZEC
| Crystal Structure of the Fab Fragment of a Glycosylated Lymphoma Antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment heavy chain, Fab fragment light chain, ... | Authors: | Allen, J.D, Watanabe, Y, Crispin, M, Bowden, T.A. | Deposit date: | 2020-06-16 | Release date: | 2021-06-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior. Blood, 138, 2021
|
|
4F3M
| Crystal structure of CRISPR-associated protein | Descriptor: | 1,2-ETHANEDIOL, BH0337 protein, SULFATE ION | Authors: | Ke, A, Nam, K.H. | Deposit date: | 2012-05-09 | Release date: | 2012-08-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System. Structure, 20, 2012
|
|
6PW3
| |
6QI9
| Truncated human R2TP complex, structure 4 (ADP-empty) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | Authors: | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | Deposit date: | 2019-01-18 | Release date: | 2019-05-15 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.63 Å) | Cite: | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
|
|
6QI8
| Truncated human R2TP complex, structure 3 (ADP-filled) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | Authors: | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | Deposit date: | 2019-01-18 | Release date: | 2019-04-10 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
|
|
6SSH
| Structure of the TSC2 GAP domain | Descriptor: | 1,2-ETHANEDIOL, GTPase activator-like protein | Authors: | Hansmann, P, Kiontke, S, Kummel, D. | Deposit date: | 2019-09-06 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Structure, 28, 2020
|
|
6F34
| |
6LR6
| The crystal structure of human cytoplasmic LRS | Descriptor: | 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, 5'-O-(L-leucylsulfamoyl)adenosine, Leucine--tRNA ligase, ... | Authors: | Liu, R.J, Long, T, Li, H, Li, J, Zhao, J.H, Lin, J.Z, Palencia, A, Wang, M.Z, Cusack, S, Wang, E.D. | Deposit date: | 2020-01-15 | Release date: | 2020-03-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.009 Å) | Cite: | Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res., 48, 2020
|
|
6MP6
| Cryo-EM structure of the human neutral amino acid transporter ASCT2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neutral amino acid transporter B(0) | Authors: | Yu, X, Han, S. | Deposit date: | 2018-10-05 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation. Elife, 8, 2019
|
|
6MPB
| Cryo-EM structure of the human neutral amino acid transporter ASCT2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMINE, Neutral amino acid transporter B(0) | Authors: | Yu, X, Han, S. | Deposit date: | 2018-10-05 | Release date: | 2019-11-06 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation. Elife, 8, 2019
|
|
5EJC
| Crystal structural of the TSC1-TBC1D7 complex | Descriptor: | Hamartin, TBC1 domain family member 7 | Authors: | Wang, Z, Qin, J, Gong, W, Xu, W. | Deposit date: | 2015-11-01 | Release date: | 2016-03-02 | Last modified: | 2019-11-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of the Interaction between Tuberous Sclerosis Complex 1 (TSC1) and Tre2-Bub2-Cdc16 Domain Family Member 7 (TBC1D7). J.Biol.Chem., 291, 2016
|
|
5HIU
| Structure of the TSC2 N-terminus | Descriptor: | GTPase activator-like protein | Authors: | Zech, R, Kiontke, S, Kummel, D. | Deposit date: | 2016-01-12 | Release date: | 2016-08-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis. J.Biol.Chem., 291, 2016
|
|
7N6Z
| Crystal Structure of PI5P4KIIAlpha | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-09 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7N
| Crystal Structure of PI5P4KIIAlpha complex with Volasertib | Descriptor: | N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7O
| Crystal Structure of PI5P4KIIAlpha complex with Palbociclib | Descriptor: | 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N81
| Crystal Structure of PI5P4KIIBeta complex with CC260 | Descriptor: | (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-11 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7J
| Crystal Structure of PI5P4KIIAlpha complex with AMPPNP | Descriptor: | MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N80
| Crystal Structure of PI5P4KIIBeta | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-11 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7M
| Crystal Structure of PI5P4KIIAlpha complex with BI-2536 | Descriptor: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7K
| Crystal Structure of PI5P4KIIAlpha complex with AMPPNP | Descriptor: | MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ... | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N7L
| Crystal Structure of PI5P4KIIAlpha complex with BI-D1870 | Descriptor: | (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-10 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7N71
| Crystal Structure of PI5P4KIIAlpha | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, SULFATE ION | Authors: | Chen, S, Ha, Y. | Deposit date: | 2021-06-09 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7KTR
| Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) | Descriptor: | Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... | Authors: | Herbst, D.A, Esbin, M.N, Nogales, E. | Deposit date: | 2020-11-24 | Release date: | 2021-11-10 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
|
|