PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

---

2JEF	The Molecular Basis of Selectivity of Nucleotide Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase IV: Steady-state and Pre-steady-state and X-Ray Crystallography of Correct and Incorrect Pairing Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*DOC)-3', 5'-D(*TP*CP*AP*CP*BZGP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP CP*CP*C)-3', ... Authors: Eoff, R.L, Angel, K.C, Kosekov, I.D, Egli, M, Guengerich, F.P. Deposit date: 2007-01-17 Release date: 2007-03-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus Solfataricus DNA Polymerase Dpo4: Steady-State and Pre-Steady-State Kinetics and X-Ray Crystallography of Correct and Incorrect Pairing. J.Biol.Chem., 282, 2007
4G94	G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex Descriptor: ORF067, RNA polymerase sigma factor rpoD Authors: Darst, S.A, Osmundson, J.S, Montero-Diaz, C.M, Hochschild, A. Deposit date: 2012-07-23 Release date: 2013-01-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9971 Å) Cite: Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell(Cambridge,Mass.), 151, 2012
1O0B	CRYSTAL STRUCTURE OF L-GLUTAMINE AND AMPCPP BOUND TO GLUTAMINE AMINOACYL TRNA SYNTHETASE Descriptor: ADENOSINE MONOPHOSPHATE, GLUTAMINE, Glutaminyl tRNA, ... Authors: Bullock, T.L, Perona, J.J. Deposit date: 2003-02-20 Release date: 2003-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Amino Acid Discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants J.Mol.Biol., 328, 2003
5IF8	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine Descriptor: 1,2-ETHANEDIOL, 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IFB	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4719 5-chloro-2-(1H-imidazol-1-yl)aniline Descriptor: 5-chloro-2-(1H-imidazol-1-yl)aniline, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5IF7	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-279 N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Descriptor: DIMETHYL SULFOXIDE, N-[(4-chlorophenyl)methyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Polymerase acidic protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
5O7T	Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a dG:dCTP base pair Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase I, thermostable, ... Authors: Betz, K, Diederichs, K, Marx, A. Deposit date: 2017-06-09 Release date: 2017-11-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. Chem. Commun. (Camb.), 53, 2017
7JMN	Tail module of Mediator complex Descriptor: MED15, Mediator of RNA polymerase II transcription subunit 14, Mediator of RNA polymerase II transcription subunit 16, ... Authors: Zhang, H.Q, Chen, D.C. Deposit date: 2020-08-02 Release date: 2021-03-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Mediator structure and conformation change. Mol.Cell, 81, 2021
4H5O	Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Pentamer Bound to Single-stranded RNA Descriptor: 35-mer poly(U) RNA, Nucleocapsid protein Authors: Raymond, D.D, Smith, J.L. Deposit date: 2012-09-18 Release date: 2012-11-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
5IF5	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to EBSI-39 (2,3-dichlorophenyl)methanol Descriptor: (2,3-dichlorophenyl)methanol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-03-08 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
2JEJ	The Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase IV: Steady-state and Pre-steady-state Kinetics and X- Ray Crystallography of Correct and Incorrect Pairing Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP *TP*TP*CP*CP*G)-3', 5'-D(*TP*CP*AP*C BZGP*GP*AP*AP*TP*CP*CP *TP*TP*CP*CP*CP*CP*C)-3', ... Authors: Eoff, R.L, Angel, K.C, Kosekov, I.D, Egli, M, Guengerich, F.P. Deposit date: 2007-01-17 Release date: 2007-03-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus Solfataricus DNA Polymerase Dpo4: Steady-State and Pre-Steady-State Kinetics and X-Ray Crystallography of Correct and Incorrect Pairing. J.Biol.Chem., 282, 2007
5IFC	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4720 1-(4-bromophenyl)-1H-imidazole Descriptor: 1-(4-bromophenyl)-1H-imidazole, DIMETHYL SULFOXIDE, Polymerase acidic protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-02-25 Release date: 2017-02-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase PA To Be Published
7KPW	Structure of the H-lobe of yeast CKM Descriptor: Mediator of RNA polymerase II transcription subunit 12 Authors: Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. Deposit date: 2020-11-12 Release date: 2021-01-27 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Sci Adv, 7, 2021
4H5P	Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Tetramer Bound to Single-stranded RNA Descriptor: 28-mer poly(U) RNA, Nucleocapsid protein Authors: Raymond, D.D, Smith, J.L. Deposit date: 2012-09-18 Release date: 2012-11-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
8UMW	Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex in the five-subunit binding state (state 4) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... Authors: Wang, F, He, Q, Li, H. Deposit date: 2023-10-18 Release date: 2024-05-08 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
1TV9	HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE Descriptor: 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... Authors: Krahn, J.M, Beard, W.M, Wilson, S.H. Deposit date: 2004-06-29 Release date: 2004-11-23 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY Structure, 12, 2004
3RMA	Crystal Structure of a replicative DNA polymerase bound to DNA containing Thymine Glycol Descriptor: DNA (5'-D(*CP*GP*AP*(CTG)*GP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*CP*A)-3'), DNA polymerase Authors: Aller, P, Duclos, S, Wallace, S.S, Doublie, S. Deposit date: 2011-04-20 Release date: 2011-08-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.84 Å) Cite: A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex. J.Mol.Biol., 412, 2011
1X9M	T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA Descriptor: 5'-D(*CP*CP*CP*(8FG)P*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*TP*GP*GP*TP*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', DNA polymerase, ... Authors: Dutta, S, Li, Y, Johnson, D, Dzantiev, L, Richardson, C.C, Romano, L.J, Ellenberger, T. Deposit date: 2004-08-23 Release date: 2004-10-26 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proc.Natl.Acad.Sci.USA, 101, 2004
4G6D	G1 ORF67 / Staphyloccus aureus sigmaA domain 4 complex Descriptor: ORF067, RNA polymerase sigma factor rpoD Authors: Darst, S.A, Osmundson, J.S. Deposit date: 2012-07-18 Release date: 2013-01-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9971 Å) Cite: Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell(Cambridge,Mass.), 151, 2012
6UOM	Y271G DNA polymerase beta ternary complex with templating adenine and incoming r8-oxo-GTP Descriptor: 1,2-ETHANEDIOL, 2',3'-DIDEOXYCYTIDINE-5'-MONOPHOSPHATE, 8-OXO-GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Smith, M.R, Freudenthal, B.D. Deposit date: 2019-10-15 Release date: 2020-01-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase beta. J.Biol.Chem., 295, 2020
2A9L	SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE Descriptor: ABISS7 RNA Authors: Diener, J.L, Moore, P.B. Deposit date: 1998-04-07 Release date: 1998-06-17 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif. Mol.Cell, 1, 1998
3MR5	Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*CP*GP*TP*CP*AP*TP*AP*A)-3'), DNA (5'-D(*TP*AP*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*A)-3'), ... Authors: Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. Deposit date: 2010-04-28 Release date: 2010-06-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
3MR3	Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... Authors: Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. Deposit date: 2010-04-28 Release date: 2010-06-30 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
3MR6	Human DNA polymerase eta - DNA ternary complex with a CPD 2bp upstream of the active site (TT4) Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*C*AP*TP*CP*AP*(TTD)P*AP*CP*GP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*CP*GP*TP*AP*AP*T)-3'), ... Authors: Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. Deposit date: 2010-04-28 Release date: 2010-06-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure and mechanism of human DNA polymerase eta. Nature, 465, 2010
6FBI	KlenTaq DNA polymerase in a closed, ternary complex with dGpNHpp bound in the active site Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... Authors: Kropp, H.M, Diederichs, K, Marx, A. Deposit date: 2017-12-19 Release date: 2018-09-26 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Snapshots of a modified nucleotide moving through the confines of a DNA polymerase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

<128129130131132133134135136137138139140141142143>