7AHX
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![BU of 7ahx by Molmil](/molmil-images/mine/7ahx) | HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND D-ASPARTATE TENOFOVIR WITH BOUND MANGANESE | Descriptor: | D-Aspartate Tenofovir, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)*CP*GP*CP*CP*(DDG))-3'), DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... | Authors: | Gu, W, Martinez, S.E, Nguyen, H, Xu, H, Herdewijn, P, de Jonghe, S, Das, K. | Deposit date: | 2020-09-25 | Release date: | 2021-01-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. J.Med.Chem., 64, 2021
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7JXT
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![BU of 7jxt by Molmil](/molmil-images/mine/7jxt) | Ovine COX-1 in complex with the subtype-selective derivative 2a | Descriptor: | 2-[4,5-bis(2-chlorophenyl)-1H-imidazol-2-yl]-6-(prop-2-en-1-yl)phenyl methoxyacetate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Ko, Y, Iaselli, M, Miciaccia, M, Friedrich, L, Schneider, G, Scilimati, A, Cingolani, G. | Deposit date: | 2020-08-27 | Release date: | 2021-09-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. Adv Sci, 8, 2021
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7PY4
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![BU of 7py4 by Molmil](/molmil-images/mine/7py4) | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BERYLLIUM TRIFLUORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Dieudonne, T, Abad-Herrera, S, Juknaviciute Laursen, M, Lejeune, M, Stock, C, Slimani, K, Jaxel, C, Lyons, J.A, Montigny, C, Gunther Pomorski, T, Nissen, P, Lenoir, G. | Deposit date: | 2021-10-08 | Release date: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders. Elife, 11, 2022
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2M1S
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2MDG
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![BU of 2mdg by Molmil](/molmil-images/mine/2mdg) | Solution NMR Structure of Zinc finger protein 423 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7298F | Descriptor: | ZINC ION, Zinc finger protein 423 | Authors: | Pederson, K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Everett, J.K, Acton, T.B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-09-10 | Release date: | 2013-09-25 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Zinc finger protein 423 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7298F To be Published
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7SJX
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![BU of 7sjx by Molmil](/molmil-images/mine/7sjx) | Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein | Descriptor: | Gag-Pol polyprotein | Authors: | Lyumkis, D, Passos, D, Arnold, E, Harrison, J.J.E.K, Ruiz, F.X. | Deposit date: | 2021-10-19 | Release date: | 2022-07-27 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation. Sci Adv, 8, 2022
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2MFE
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![BU of 2mfe by Molmil](/molmil-images/mine/2mfe) | Csr/Rsm protein-RNA recognition - A molecular affinity ruler: RsmZ(SL2)/RsmE(dimer) 2:1 complex | Descriptor: | Carbon storage regulator homolog, SL2(RsmZ) RNA | Authors: | Duss, O, Diarra Dit Konte, N, Michel, E, Schubert, M, Allain, F.H.-T. | Deposit date: | 2013-10-11 | Release date: | 2014-02-26 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Molecular basis for the wide range of affinity found in Csr/Rsm protein-RNA recognition. Nucleic Acids Res., 42, 2014
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7E4W
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2ZUH
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![BU of 2zuh by Molmil](/molmil-images/mine/2zuh) | Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant (D297A) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Camphor 5-monooxygenase, ... | Authors: | Sakurai, K, Harada, K, Shimada, H, Shimokata, K, Hayashi, T, Tsukihara, T. | Deposit date: | 2008-10-18 | Release date: | 2009-10-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant to be published
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2ZWF
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8OQZ
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![BU of 8oqz by Molmil](/molmil-images/mine/8oqz) | Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | Deposit date: | 2023-04-12 | Release date: | 2024-04-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15, 2024
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7DU6
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7AO5
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![BU of 7ao5 by Molmil](/molmil-images/mine/7ao5) | Crystal structure of CotB2 variant W288F | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclooctat-9-en-7-ol synthase, MAGNESIUM ION | Authors: | Dimos, N, Driller, R, Loll, B. | Deposit date: | 2020-10-13 | Release date: | 2020-12-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | The Impression of a Nonexisting Catalytic Effect: The Role of CotB2 in Guiding the Complex Biosynthesis of Cyclooctat-9-en-7-ol. J.Am.Chem.Soc., 142, 2020
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2MI7
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![BU of 2mi7 by Molmil](/molmil-images/mine/2mi7) | Solution NMR structure of alpha3Y | Descriptor: | de novo protein a3Y | Authors: | Glover, S.D, Jorge, C, Liang, L, Valentine, K.G, Hammarstrom, L, Tommos, C. | Deposit date: | 2013-12-10 | Release date: | 2014-08-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Photochemical tyrosine oxidation in the structurally well-defined alpha 3Y protein: proton-coupled electron transfer and a long-lived tyrosine radical. J.Am.Chem.Soc., 136, 2014
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7Q19
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![BU of 7q19 by Molmil](/molmil-images/mine/7q19) | Beta-lactoglobulin mutant FAW (I56F/L39A/M107W) in complex with desipramine (FAW-DSM#3) | Descriptor: | 1,2-ETHANEDIOL, 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, Beta-lactoglobulin, ... | Authors: | Loch, J.I, Barciszewski, J, Pokrywka, K, Lewinski, K. | Deposit date: | 2021-10-18 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | New ligand-binding sites identified in the crystal structures of [beta]-lactoglobulin complexes with desipramine Iucrj, 9, 2022
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7DU7
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2J4O
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![BU of 2j4o by Molmil](/molmil-images/mine/2j4o) | Structure of TAB1 | Descriptor: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1 | Authors: | van Aalten, D. | Deposit date: | 2006-09-01 | Release date: | 2006-09-04 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Tak1-Binding Protein 1 is a Pseudophosphatase. Biochem.J., 399, 2006
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2ZVW
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![BU of 2zvw by Molmil](/molmil-images/mine/2zvw) | Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21 | Descriptor: | Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen 2, SULFATE ION | Authors: | Strzalka, W, Oyama, T, Tori, K, Morikawa, K. | Deposit date: | 2008-11-21 | Release date: | 2009-06-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment Protein Sci., 18, 2009
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7SPM
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![BU of 7spm by Molmil](/molmil-images/mine/7spm) | Replication Initiator Protein REPE54 and cognate DNA sequence with terminal three prime phosphates chemically crosslinked (30 mg/mL EDC, 12 hours, 2 doses). | Descriptor: | DNA (5'-D(*CP*CP*TP*GP*TP*GP*AP*CP*AP*AP*AP*TP*TP*GP*CP*CP*CP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*GP*GP*GP*CP*AP*AP*TP*TP*TP*GP*TP*CP*AP*CP*AP*GP*GP*A)-3'), MAGNESIUM ION, ... | Authors: | Ward, A.R, Snow, C.D. | Deposit date: | 2021-11-02 | Release date: | 2021-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Stabilizing DNA-Protein Co-Crystals via Intra-Crystal Chemical Ligation of the DNA Crystals, 12, 2022
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7DXX
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7JVH
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![BU of 7jvh by Molmil](/molmil-images/mine/7jvh) | Crystal structure of a GH43_12 retrieved from capybara gut metagenome | Descriptor: | GLYCEROL, Glycoside Hydrolase Family 43_12 | Authors: | Cabral, L, Domingues, M.N, Martins, M.P, Persinoti, G.F, Morais, M.A.B, Murakami, M.T. | Deposit date: | 2020-08-21 | Release date: | 2021-09-08 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal structure of a GH43_12 retrieved from capybara gut metagenome To Be Published
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7PGX
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![BU of 7pgx by Molmil](/molmil-images/mine/7pgx) | Structure of dark-adapted AsLOV2 wild type | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Gelfert, R, Weyand, M, Moeglich, A. | Deposit date: | 2021-08-16 | Release date: | 2022-05-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.001 Å) | Cite: | Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine. Nat Commun, 13, 2022
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7DXZ
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7DVH
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2MGY
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![BU of 2mgy by Molmil](/molmil-images/mine/2mgy) | Solution structure of the mitochondrial translocator protein (TSPO) in complex with its high-affinity ligand PK11195 | Descriptor: | N-[(2R)-butan-2-yl]-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide, Translocator protein | Authors: | Jaremko, M, Jaremko, L, Giller, K, Becker, S, Zweckstetter, M. | Deposit date: | 2013-11-11 | Release date: | 2014-04-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science, 343, 2014
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