PDB: 46006 resultsInfo pagesStatus searchChemie searchBIRD

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3LFC	Human p38 MAP Kinase in Complex with RL99 Descriptor: (4-{5-[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}carbamoyl)amino]-3-tert-butyl-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. Deposit date: 2010-01-16 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
5C35	Constitutively active Sin recombinase cataltyic domain - T77II100T/Q115R Descriptor: Recombinase Sin, SULFATE ION Authors: Trejo, C.S, Rice, P.A. Deposit date: 2015-06-16 Release date: 2016-12-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Snapshots of a molecular swivel in action Nucleic Acids Res., 2018
2EBB	Crystal structure of pterin-4-alpha-carbinolamine dehydratase (pterin carbinolamine dehydratase) from Geobacillus kaustophilus HTA426 Descriptor: Pterin-4-alpha-carbinolamine dehydratase Authors: Kumarevel, T.S, Karthe, P, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-02-07 Release date: 2008-02-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of pterin-4-alpha-carbinolamine dehydratase (pterin carbinolamine dehydratase) from Geobacillus kaustophilus HTA426 To be Published
2EET	Guanine Riboswitch A21G, U75C mutant bound to hypoxanthine Descriptor: ACETATE ION, COBALT HEXAMMINE(III), Guanine Riboswitch, ... Authors: Gilbert, S.D, Edwards, A.L, Batey, R.T. Deposit date: 2007-02-18 Release date: 2007-11-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Mutational analysis of the purine riboswitch aptamer domain Biochemistry, 46, 2007
2EC8	Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Authors: Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J. Deposit date: 2007-02-11 Release date: 2007-08-07 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor Cell(Cambridge,Mass.), 130, 2007
2EEU	Guanine riboswitch U22A, A52U mutant bound to hypoxanthine Descriptor: ACETATE ION, COBALT HEXAMMINE(III), Guanine riboswitch, ... Authors: Gilbert, S.D, Love, C.E, Batey, R.T. Deposit date: 2007-02-19 Release date: 2007-11-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Mutational analysis of the purine riboswitch aptamer domain Biochemistry, 46, 2007
2EEZ	Crystal structure of alanine dehydrogenase from themus thermophilus Descriptor: Alanine dehydrogenase Authors: Kumarevel, T.S, Karthe, P, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-02-19 Release date: 2007-04-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Crystal structure of alanine dehydrogenase from themus thermophilus To be Published
7JQG	Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with GW1929 Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2020-08-10 Release date: 2021-03-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021
2EHH	Crystal structure of dihydrodipicolinate synthase from aquifex aeolicus Descriptor: Dihydrodipicolinate synthase, PHOSPHATE ION Authors: Kumarevel, T.S, Karthe, P, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-06 Release date: 2007-05-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of dihydrodipicolinate synthase from aquifex aeolicus To be Published
2EIU	Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus Descriptor: Hypothetical protein aq_1627 Authors: Kumarevel, T.S, Karthe, P, Nakano, N, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-13 Release date: 2007-09-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus To be Published
3LFF	Human p38 MAP Kinase in Complex with RL166 Descriptor: (4-{3-tert-butyl-5-[(1,3-thiazol-2-ylcarbamoyl)amino]-1H-pyrazol-1-yl}phenyl)acetic acid, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. Deposit date: 2010-01-16 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
2EBD	Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Aquifex aeolicus VF5 Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Kumarevel, T.S, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-02-08 Release date: 2007-08-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase III from Aquifex aeolicus VF5 To be Published
4OLB	Crystal Structure of Human Argonaute2 Bound to Tryptophan Descriptor: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', Protein argonaute-2, TRYPTOPHAN Authors: Schirle, N.T, MacRae, I.J. Deposit date: 2014-01-23 Release date: 2014-02-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.899 Å) Cite: The crystal structure of human Argonaute2. Science, 336, 2012
2J2I	Crystal Structure of the humab PIM1 in complex with LY333531 Descriptor: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION Authors: Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. Deposit date: 2006-08-16 Release date: 2007-02-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. U.S.A., 104, 2007
3LFE	Human p38 MAP Kinase in Complex with RL116 Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-4-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. Deposit date: 2010-01-16 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
2R4G	The high resolution structure of the RNA-binding domain of telomerase Descriptor: BROMIDE ION, Telomerase reverse transcriptase Authors: Rouda, S, Skordalakes, E. Deposit date: 2007-08-31 Release date: 2007-11-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding. Structure, 15, 2007
4NJ7	PB1 Domain of AtARF7 - SeMet Derivative Descriptor: Auxin response factor 7 Authors: Korasick, D.A, Westfall, C.S, Lee, S.G, Nanao, M, Jez, J.M, Strader, L.C. Deposit date: 2013-11-08 Release date: 2014-03-26 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. Proc.Natl.Acad.Sci.USA, 111, 2014
2EGI	Crystal Structure of a Hypothetical Protein(AQ1494) from Aquifex aeolicus Descriptor: GLYCEROL, Hypothetical protein aq_1494 Authors: Kumarevel, T.S, Karthe, P, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-03-01 Release date: 2007-09-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of a Hypothetical Protein(AQ1494) from Aquifex aeolicus To be Published
7KCO	ROR gamma in complex with SCR2 and compound 3 Descriptor: 1-[(2-chlorophenyl)methyl]-N-{[4-(methylsulfonyl)phenyl]methyl}-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-2'-carboxamide, GLYCEROL, Nuclear receptor ROR-gamma, ... Authors: Durbin, J.D, Guo, S.Y, Stout, S.L, Clawson, D.K. Deposit date: 2020-10-06 Release date: 2021-04-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (ROR gamma t). J.Med.Chem., 64, 2021
3LFB	Human p38 MAP Kinase in Complex with RL98 Descriptor: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. Deposit date: 2010-01-16 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
2EF0	Crystal structure of ornithine carbamoyltransferase from thermus thermophilus Descriptor: MAGNESIUM ION, Ornithine carbamoyltransferase, SODIUM ION Authors: Karthe, P, Kumarevel, T.S, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-02-19 Release date: 2007-04-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of ornithine carbamoyltransferase from thermus thermophilus To be Published
2ELA	Crystal Structure of the PTB domain of human APPL1 Descriptor: Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 Authors: Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. Deposit date: 2007-03-27 Release date: 2007-05-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
4NRT	Human Norovirus polymerase bound to Compound 6 (suramin derivative) Descriptor: 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, hNV-RdRp Authors: Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Milani, M, Bolognesi, M. Deposit date: 2013-11-27 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.022 Å) Cite: Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Plos One, 9, 2014
4NJ6	PB1 Domain of AtARF7 Descriptor: Auxin response factor 7 Authors: Korasick, D.A, Westfall, C.S, Lee, S.G, Nanao, M, Jez, J.M, Strader, L.C. Deposit date: 2013-11-08 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. Proc.Natl.Acad.Sci.USA, 111, 2014
4A9Y	P38ALPHA MAP KINASE BOUND TO CMPD 8 Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE Authors: Gerhardt, S, Hargreaves, D. Deposit date: 2011-11-29 Release date: 2012-05-16 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012

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