3S8L
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3S8O
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3S9K
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![BU of 3s9k by Molmil](/molmil-images/mine/3s9k) | Crystal structure of the Itk SH2 domain. | Descriptor: | CITRIC ACID, Tyrosine-protein kinase ITK/TSK | Authors: | Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. | Deposit date: | 2011-06-01 | Release date: | 2012-02-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
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3T04
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![BU of 3t04 by Molmil](/molmil-images/mine/3t04) | Crystal structure of monobody 7c12/abl1 sh2 domain complex | Descriptor: | GLYCEROL, MONOBODY 7C12, SULFATE ION, ... | Authors: | Wojcik, J.B, Wyrzucki, A.M, Koide, S. | Deposit date: | 2011-07-19 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
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3TKZ
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![BU of 3tkz by Molmil](/molmil-images/mine/3tkz) | Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide | Descriptor: | PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | Deposit date: | 2011-08-29 | Release date: | 2011-10-26 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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3TL0
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![BU of 3tl0 by Molmil](/molmil-images/mine/3tl0) | Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide | Descriptor: | RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | Deposit date: | 2011-08-29 | Release date: | 2011-09-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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4A55
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![BU of 4a55 by Molmil](/molmil-images/mine/4a55) | Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 | Descriptor: | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PIK-108 | Authors: | Hon, W.-C, Berndt, A, Williams, R.L. | Deposit date: | 2011-10-24 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases. Oncogene, 31, 2012
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3UF4
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3US4
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3UYO
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2LNW
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![BU of 2lnw by Molmil](/molmil-images/mine/2lnw) | Identification and structural basis for a novel interaction between Vav2 and Arap3 | Descriptor: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 | Authors: | Wu, B, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2012-01-05 | Release date: | 2012-11-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
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2LNX
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![BU of 2lnx by Molmil](/molmil-images/mine/2lnx) | Solution structure of Vav2 SH2 domain | Descriptor: | Guanine nucleotide exchange factor VAV2 | Authors: | Wu, B, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2012-01-05 | Release date: | 2012-11-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
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4D8K
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4DGP
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![BU of 4dgp by Molmil](/molmil-images/mine/4dgp) | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | Deposit date: | 2012-01-26 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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4DGX
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![BU of 4dgx by Molmil](/molmil-images/mine/4dgx) | LEOPARD Syndrome-Associated SHP2/Y279C mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | Deposit date: | 2012-01-27 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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2LQN
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![BU of 2lqn by Molmil](/molmil-images/mine/2lqn) | Solution structure of CRKL | Descriptor: | Crk-like protein | Authors: | Jankowski, W, Saleh, T, Kalodimos, C. | Deposit date: | 2012-03-09 | Release date: | 2012-05-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
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4E68
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![BU of 4e68 by Molmil](/molmil-images/mine/4e68) | Unphosphorylated STAT3B core protein binding to dsDNA | Descriptor: | DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3 | Authors: | Collie, G.W, Parkinson, G.N, Shah, R. | Deposit date: | 2012-03-15 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.585 Å) | Cite: | Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Febs Lett., 587, 2013
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2LQW
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4E93
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![BU of 4e93 by Molmil](/molmil-images/mine/4e93) | Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 | Descriptor: | 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps | Authors: | Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2012-03-20 | Release date: | 2012-04-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
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4EIH
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![BU of 4eih by Molmil](/molmil-images/mine/4eih) | Crystal structure of Arg SH2 domain | Descriptor: | Abelson tyrosine-protein kinase 2, CHLORIDE ION | Authors: | Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J. | Deposit date: | 2012-04-05 | Release date: | 2013-04-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin. J.Biol.Chem., 289, 2014
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3VS7
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![BU of 3vs7 by Molmil](/molmil-images/mine/3vs7) | Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Descriptor: | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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3VS1
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![BU of 3vs1 by Molmil](/molmil-images/mine/3vs1) | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | Descriptor: | 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.464 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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3VS4
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![BU of 3vs4 by Molmil](/molmil-images/mine/3vs4) | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | Descriptor: | 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.747 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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3VS0
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![BU of 3vs0 by Molmil](/molmil-images/mine/3vs0) | Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | Descriptor: | CALCIUM ION, CHLORIDE ION, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide, ... | Authors: | Kuratani, M, Honda, K, Tomabechi, Y, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.934 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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3VS6
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![BU of 3vs6 by Molmil](/molmil-images/mine/3vs6) | Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Descriptor: | CALCIUM ION, CHLORIDE ION, Tyrosine-protein kinase HCK, ... | Authors: | Kuratani, M, Honda, K, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. | Deposit date: | 2012-04-21 | Release date: | 2013-05-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.373 Å) | Cite: | A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
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