2V23
 
 | | Structure of cytochrome c peroxidase mutant N184R Y36A | | Descriptor: | CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Metcalfe, C.L, Macdonald, I.K, Brown, K.A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2007-05-31 | | Release date: | 2007-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
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2V2E
 | | Structure of isoniazid (INH) bound to cytochrome c peroxidase mutant N184R Y36A | | Descriptor: | 4-(DIAZENYLCARBONYL)PYRIDINE, CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Metcalfe, C.L, Macdonald, I.K, Brown, K.A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2007-06-05 | | Release date: | 2007-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | The Tuberculosis Prodrug Isoniazid Bound to Activating Peroxidases.
J.Biol.Chem., 283, 2008
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4A6Z
 | | Cytochrome c peroxidase with bound guaiacol | | Descriptor: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, Guaiacol, ... | | Authors: | Murphy, E.J, Metcalfe, C.L, Nnamchi, C, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2011-11-10 | | Release date: | 2012-10-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A7M
 | | cytochrome c peroxidase S81W mutant | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | Authors: | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2011-11-14 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A78
 | | cytochrome c peroxidase M119W in complex with guiacol | | Descriptor: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, Guaiacol, ... | | Authors: | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2011-11-11 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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4A71
 | | cytochrome c peroxidase in complex with phenol | | Descriptor: | CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, PHENOL, ... | | Authors: | Murphy, E.J, Metcalfe, C.L, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2011-11-10 | | Release date: | 2012-10-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Crystal Structure of Guaiacol and Phenol Bound to a Heme Peroxidase.
FEBS J., 279, 2012
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2X08
 | | cytochrome c peroxidase: ascorbate bound to the engineered ascorbate binding site | | Descriptor: | ASCORBIC ACID, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | Authors: | Murphy, E.J, Metcalfe, C.L, Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2009-12-07 | | Release date: | 2010-11-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Biochemistry, 47, 2008
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2XIL
 | | The structure of cytochrome c peroxidase Compound I | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOCHROME C PEROXIDASE, ... | | Authors: | Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2010-06-30 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Nature of the ferryl heme in compounds I and II.
J. Biol. Chem., 286, 2011
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2XJ5
 | | The structure of cytochrome c peroxidase Compound II | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | Authors: | Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2010-07-02 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Nature of the ferryl heme in compounds I and II.
J. Biol. Chem., 286, 2011
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2X07
 | | cytochrome c peroxidase: engineered ascorbate binding site | | Descriptor: | Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Murphy, E.J, Metcalfe, C.L, Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2009-12-07 | | Release date: | 2010-11-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase.
Biochemistry, 47, 2008
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2XJ8
 | | The structure of ferrous cytochrome c peroxidase | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | Authors: | Gumiero, A, Raven, E.L, Moody, P.C.E. | | Deposit date: | 2010-07-02 | | Release date: | 2010-07-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Nature of the ferryl heme in compounds I and II.
J. Biol. Chem., 286, 2011
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2Y5A
 | | Cytochrome c peroxidase (CCP) W191G bound to 3-aminopyridine | | Descriptor: | 3-AMINOPYRIDINE, CYTOCHROME C PEROXIDASE, MITOCHONDRIAL, ... | | Authors: | Cappel, D, Wahlstrom, R, Brenk, R, Sotriffer, C.A. | | Deposit date: | 2011-01-12 | | Release date: | 2011-10-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Probing the Dynamic Nature of Water Molecules and Their Influences on Ligand Binding in a Model Binding Site.
J.Chem.Inf.Model, 51, 2011
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2YCG
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8B8G
 | | Cryo-EM structure of Ca2+-free mTMEM16F F518H mutant in Digitonin | | Descriptor: | Anoctamin-6 | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8J
 | | Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8K
 | | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed | | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8BC0
 | | Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8BC1
 | | Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN | | Descriptor: | Anoctamin-6,mTMEM16F, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-14 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8M
 | | Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-11-16 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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8B8Q
 | | Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | | Descriptor: | Anoctamin-6, CALCIUM ION | | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | Deposit date: | 2022-10-04 | | Release date: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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7Q5D
 | | Structure of EPCR in a non-canonical conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Endothelial protein C receptor, ... | | Authors: | Lopez-Sagaseta, J, Erausquin, E. | | Deposit date: | 2021-11-03 | | Release date: | 2022-09-14 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of EPCR in a non-canonical conformation
Biorxiv, 2021
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7S1Z
 | | Cryo-EM structure of Human NKCC1 K289NA492EL671C | | Descriptor: | Solute carrier family 12 member 2 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2021-09-02 | | Release date: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
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8GPR
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6M6Z
 | | A de novo designed transmembrane nanopore, TMH4C4 | | Descriptor: | TMH4C4 | | Authors: | Lu, P, Xu, C, Reggiano, G, Xu, Q, DiMaio, F, Baker, D. | | Deposit date: | 2020-03-16 | | Release date: | 2020-06-24 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Computational design of transmembrane pores.
Nature, 585, 2020
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6PZT
 | | cryo-EM structure of human NKCC1 | | Descriptor: | Solute carrier family 12 member 2 | | Authors: | Cao, E, Wang, Q, Yang, X. | | Deposit date: | 2019-08-01 | | Release date: | 2020-03-25 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.
Nat Commun, 11, 2020
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