PDB Search results for query - Protein Data Bank Japan

PDB: 342 results Info pages Status search Chemie search BIRD

Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor:	CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:	Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G.
Deposit date:	2006-04-09
Release date:	2006-06-27
Last modified:	2017-06-28
Method:	X-RAY DIFFRACTION (1.67 Å)
Cite:	Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis J.Mol.Biol., 359, 2006

2FP3

Crystal structure of the Drosophila initiator caspase Dronc
Descriptor:	Caspase Nc
Authors:	Yan, N, Gu, L, Shi, Y.
Deposit date:	2006-01-15
Release date:	2006-01-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structure and activation mechanism of the Drosophila initiator caspase dronc J.Biol.Chem., 281, 2006

2FQQ

Crystal structure of human caspase-1 (Cys285->Ala, Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 1-methyl-3-trifluoromethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethyl)-amide
Descriptor:	1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE, Caspase-1
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-01-18
Release date:	2006-05-16
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2J30

The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)caspase-3
Descriptor:	ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3
Authors:	Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:	2006-08-17
Release date:	2006-11-08
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006

2J33

The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)caspase-3
Descriptor:	ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3
Authors:	Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:	2006-08-17
Release date:	2006-11-08
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006

2J31

The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of(Pro)caspase-3
Descriptor:	ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3
Authors:	Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:	2006-08-17
Release date:	2006-11-08
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006

2HBR

Crystal structure of human caspase-1 (Arg286->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-06-14
Release date:	2006-06-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2HBZ

Crystal structure of human caspase-1 (Arg286->Ala, Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, PHQ-VAD-fluoromethylketone inhibitor
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-06-14
Release date:	2006-06-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2HBY

Crystal structure of human caspase-1 (Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-06-14
Release date:	2006-06-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2H65

Crystal strusture of caspase-3 with inhibitor Ac-VDVAD-Cho
Descriptor:	Ac-VDVAD-Cho, caspase-3, p12 subunit, ...
Authors:	Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:	2006-05-30
Release date:	2006-09-19
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006

2J32

The Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of(Pro)caspase-3
Descriptor:	ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CASPASE-3
Authors:	Feeney, B, Pop, C, Swartz, P, Mattos, C, Clark, A.C.
Deposit date:	2006-08-17
Release date:	2006-11-08
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Role of Loop Bundle Hydrogen Bonds in the Maturation and Activity of (Pro)Caspase-3. Biochemistry, 45, 2006

2K7Z

Solution Structure of the Catalytic Domain of Procaspase-8
Descriptor:	Caspase-8
Authors:	Keller, N, Zerbe, O, Mares, J, Gruetter, M.G.
Deposit date:	2008-08-28
Release date:	2009-03-24
Last modified:	2024-05-08
Method:	SOLUTION NMR
Cite:	Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure, 17, 2009

2HBQ

Crystal structure of wildtype human caspase-1 in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-06-14
Release date:	2006-06-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A Common Allosteric Site and Mechanism in Caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2H5I

Crystal structure of caspase-3 with inhibitor Ac-DEVD-Cho
Descriptor:	Ac-DEV(ASJ), caspase-3, p12 subunit, ...
Authors:	Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:	2006-05-26
Release date:	2006-09-19
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.69 Å)
Cite:	Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006

2H48

Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase 1, isoform gamma, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-05-23
Release date:	2006-06-06
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A common allosteric site and mechanism in caspases Proc.Natl.Acad.Sci.USA, 103, 2006

2H54

Crystal structure of human caspase-1 (Thr388->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-05-25
Release date:	2008-03-11
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008

2H4Y

Crystal structure of human caspase-1 (Arg286->Lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-05-25
Release date:	2008-03-11
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008

2H51

Crystal structure of human caspase-1 (Glu390->Asp and Arg286->Lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-05-25
Release date:	2008-03-11
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008

2H5J

Crystal strusture of caspase-3 with inhibitor Ac-DMQD-Cho
Descriptor:	Ac-DMQD-Cho, caspase-3, p12 subunit, ...
Authors:	Fang, B, Boross, P.I, Tozser, J, Weber, I.T.
Deposit date:	2006-05-26
Release date:	2006-09-19
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360, 2006

2H4W

Crystal structure of human caspase-1 (Glu390->Asp) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Scheer, J.M, Wells, J.A, Romanowski, M.J.
Deposit date:	2006-05-25
Release date:	2008-03-11
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	An allosteric circuit in caspase-1. J.Mol.Biol., 381, 2008

1RWO

Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-ylamino)-benzoylamino]-2-thiophen-2-yl-hexanoylamino}-pentanoic acid
Descriptor:	4-OXO-3-{6-[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-PENTANOIC ACID, Interleukin-1 beta convertase
Authors:	Romanowski, M.J, Waal, N.D, Fahr, B.T, O'Brien, T.
Deposit date:	2003-12-16
Release date:	2004-12-28
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005

1SHJ

Caspase-7 in complex with DICA allosteric inhibitor
Descriptor:	2-(2,4-DICHLORO-PHENOXY)-N-(2-MERCAPTO-ETHYL)-ACETAMIDE, Caspase-7, SULFATE ION
Authors:	Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A.
Deposit date:	2004-02-25
Release date:	2004-08-17
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Discovery of an allosteric site in the caspases Proc.Natl.Acad.Sci.USA, 101, 2004

1RWN

Crystal structure of human caspase-1 in complex with 3-{2-ethyl-6-[4-(quinoxalin-2-ylamino)-benzoylamino]-hexanoylamino}-4-oxo-butyric acid
Descriptor:	3-{2-ETHYL-6-[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-HEXANOYLAMINO}-4-OXO-BUTYRIC ACID, Interleukin-1 beta convertase
Authors:	Romanowski, M.J, Fahr, B.T, O'Brien, T.
Deposit date:	2003-12-16
Release date:	2004-12-28
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005

1RWV

Crystal structure of human caspase-1 in complex with 5-[5-(1-carboxymethyl-2-oxo-propylcarbamoyl)-5-phenyl-pentylsulfamoyl]-2-hydroxy-benzoic acid
Descriptor:	5-[5-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-5-PHENYL-PENTYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID, Interleukin-1 beta convertase
Authors:	Romanowski, M.J, Burdett, M.T, Fahr, B.T, O'Brien, T.
Deposit date:	2003-12-17
Release date:	2004-12-28
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Novel Caspase-1 Inhibitors Discovered Using Tethering(SM) with Extenders TO BE PUBLISHED

1RWM

Crystal structure of human caspase-1 in complex with 4-oxo-3-[2-(5-{[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}-thiophen-2-yl)-acetylamino]-pentanoic acid
Descriptor:	4-OXO-3-[2-(5-{[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-METHYL}-THIOPHEN-2-YL)-ACETYLAMINO]-PENTANOIC ACID, Interleukin-1 beta convertase
Authors:	Romanowski, M.J, Waal, N.D, Fahr, B.T, O'Brien, T.
Deposit date:	2003-12-16
Release date:	2004-12-28
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr.,Sect.F, 61, 2005

<3 4 5 6 7 8 91011 12 13 14 >

Total results:	342
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	PF00656