1RWV

Crystal structure of human caspase-1 in complex with 5-[5-(1-carboxymethyl-2-oxo-propylcarbamoyl)-5-phenyl-pentylsulfamoyl]-2-hydroxy-benzoic acid

Summary for 1RWV

• Entry DOI: 10.2210/pdb1rwv/pdb
• Related: 1bmq 1ibc 1ice 1rwk 1rwm 1rwn 1rwo 1rwp 1rww 1rwx
• Descriptor: Interleukin-1 beta convertase, 5-[5-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-5-PHENYL-PENTYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: protein-small molecule inhibitor complex, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P29466 P29466
• Total number of polymer chains: 2
• Total formula weight: 30649.15

Authors

Romanowski, M.J.,Burdett, M.T.,Fahr, B.T.,O'Brien, T. (deposition date: 2003-12-17, release date: 2004-12-28, Last modification date: 2023-08-23)

• Primary citation: O'Brien, T.,Fahr, B.T.,Sopko, M.M.,Lam, J.W.,Waal, N.D.,Raimundo, B.C.,Purkey, H.E.,Pham, P.,Romanowski, M.J.; Novel Caspase-1 Inhibitors Discovered Using Tethering(SM) with Extenders; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.1 Å)