1RWN

Crystal structure of human caspase-1 in complex with 3-{2-ethyl-6-[4-(quinoxalin-2-ylamino)-benzoylamino]-hexanoylamino}-4-oxo-butyric acid

Summary for 1RWN

• Entry DOI: 10.2210/pdb1rwn/pdb
• Related: 1bmq 1ibc 1ice 1rwk 1rwm 1rwo 1rwp 1rwv 1rww 1rwx
• Descriptor: Interleukin-1 beta convertase, 3-{2-ETHYL-6-[4-(QUINOXALIN-2-YLAMINO)-BENZOYLAMINO]-HEXANOYLAMINO}-4-OXO-BUTYRIC ACID, ... (4 entities in total)
• Functional Keywords: protein-small molecule inhibitor complex, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P29466 P29466
• Total number of polymer chains: 2
• Total formula weight: 30634.16

Authors

Romanowski, M.J.,Fahr, B.T.,O'Brien, T. (deposition date: 2003-12-16, release date: 2004-12-28, Last modification date: 2023-08-23)

• Primary citation: O'Brien, T.,Fahr, B.T.,Sopko, M.M.,Lam, J.W.,Waal, N.D.,Raimundo, B.C.,Purkey, H.E.,Pham, P.,Romanowski, M.J.; Structural analysis of caspase-1 inhibitors derived from Tethering.; Acta Crystallogr.,Sect.F, 61:451-458, 2005; PubMed: 16511067; DOI: 10.1107/S1744309105010109

Experimental method

X-RAY DIFFRACTION (2 Å)