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PDB: 63 件
8FTY
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BU of 8fty by Molmil
Crystal structure of the carotenoid isomerooxygenase, NinaB
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, CHLORIDE ION, ...
著者Kiser, P.D, Solano, Y.J.
登録日2023-01-14
公開日2024-01-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore.
Nat.Chem.Biol., 2024
7L0E
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BU of 7l0e by Molmil
Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate
分子名称: (1R)-3-amino-1-{3-[(4,4-difluorocyclohexyl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ...
著者Kiser, P.D.
登録日2020-12-11
公開日2021-06-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
J.Med.Chem., 64, 2021
4ZHK
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BU of 4zhk by Molmil
Crystal structure of RPE65 in complex with MB-002
分子名称: (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ...
著者Kiser, P.D, Palczewski, K.
登録日2015-04-25
公開日2015-05-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
J.Clin.Invest., 125, 2015
8DOC
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BU of 8doc by Molmil
Crystal structure of RPE65 in complex with compound 16e and palmitate
分子名称: (1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, FE (II) ION, ...
著者Bassetto, M, Kiser, P.D.
登録日2022-07-12
公開日2023-05-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.
J.Med.Chem., 66, 2023
7QR6
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BU of 7qr6 by Molmil
Stilbene dioxygenase (NOV1) from Novosphingobium aromaticivorans: Ser283Phe mutant
分子名称: Dioxygenase, FE (III) ION, OXYGEN MOLECULE
著者Alvigini, L, Mattevi, A.
登録日2022-01-10
公開日2022-08-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Rationally Guided Improvement of NOV1 Dioxygenase for the Conversion of Lignin-Derived Isoeugenol to Vanillin.
Biochemistry, 62, 2023
3FSN
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BU of 3fsn by Molmil
Crystal structure of RPE65 at 2.14 angstrom resolution
分子名称: FE (II) ION, Retinal pigment epithelium-specific 65 kDa protein, TETRAETHYLENE GLYCOL
著者Kiser, P.D, Lodowski, D.T, Palczewski, K.
登録日2009-01-11
公開日2009-09-29
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.
Proc.Natl.Acad.Sci.USA, 106, 2009
6C7P
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BU of 6c7p by Molmil
Crystal structure of D477G ACO/RPE65 chimera, monoclinic crystal form
分子名称: Apocarotenoid-15,15'-oxygenase, FE (II) ION
著者Kiser, P.D, Shi, W.
登録日2018-01-23
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.
Hum.Mol.Genet., 27, 2018
6C7O
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BU of 6c7o by Molmil
Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form
分子名称: Apocarotenoid-15,15'-oxygenase, FE (II) ION
著者Kiser, P.D, Shi, W.
登録日2018-01-23
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65.
Hum.Mol.Genet., 27, 2018
2BIX
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BU of 2bix by Molmil
Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, Fe-free apoenzyme
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, APOCAROTENOID-CLEAVING OXYGENASE, GLYCEROL
著者Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E.
登録日2005-01-26
公開日2005-04-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献The Structure of a Retinal-Forming Carotenoid Oxygenase
Science, 308, 2005
2BIW
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BU of 2biw by Molmil
Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, native enzyme
分子名称: (3R)-3-HYDROXY-8'-APOCAROTENOL, APOCAROTENOID-CLEAVING OXYGENASE, FE (III) ION
著者Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E.
登録日2005-01-26
公開日2005-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献The Structure of a Retinal-Forming Carotenoid Oxygenase
Science, 308, 2005
7T8P
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BU of 7t8p by Molmil
CRYSTAL STRUCTURE OF T151V CAO1
分子名称: CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION
著者Daruwalla, A, Kiser, P.D.
登録日2021-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献CRYSTAL STRUCTURE OF T151V CAO1
To Be Published
7T8Q
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BU of 7t8q by Molmil
CRYSTAL STRUCTURE OF T151G CAO1
分子名称: CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION
著者Daruwalla, A, Kiser, P.D.
登録日2021-12-16
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献CRYSTAL STRUCTURE OF T151G CAO1
To Be Published
3KVC
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BU of 3kvc by Molmil
Crystal structure of bovine RPE65 at 1.9 angstrom resolution
分子名称: FE (II) ION, Retinoid isomerohydrolase
著者Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K.
登録日2009-11-29
公開日2010-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
J.Biol.Chem., 285, 2010
3NPE
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BU of 3npe by Molmil
Structure of VP14 in complex with oxygen
分子名称: 1,4-DIETHYLENE DIOXIDE, 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic, ...
著者Messing, S.A, Gabelli, S.B, Amzel, L.M.
登録日2010-06-28
公開日2010-11-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid.
Plant Cell, 22, 2010
7VUD
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BU of 7vud by Molmil
Carotenoid Cleavage Dioxygenase 1 from Osmanthus fragrans
分子名称: Carotenoid cleavage dioxygenase 1, NICKEL (II) ION, OXTOXYNOL-10, ...
著者Sharma, D, Xue, B.
登録日2021-11-02
公開日2022-11-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Carotenoid Cleavage Dioxygenase 1 from Osmanthus fragrans
To Be Published
7WH1
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BU of 7wh1 by Molmil
structure of C elegans BCMO-2
分子名称: Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ...
著者Pan, W, Liu, L.
登録日2021-12-29
公開日2022-02-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans .
Front Mol Biosci, 9, 2022
7WH0
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BU of 7wh0 by Molmil
structure of C elegans BCMO-1
分子名称: Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ...
著者Pan, W, Liu, L.
登録日2021-12-29
公開日2022-02-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans .
Front Mol Biosci, 9, 2022
6VCG
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BU of 6vcg by Molmil
Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase, cobalt form
分子名称: CHLORIDE ION, COBALT (II) ION, SODIUM ION, ...
著者Daruwalla, A, Shi, W, Kiser, P.D.
登録日2019-12-20
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VCH
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BU of 6vch by Molmil
Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase in complex with 3-hydroxy-beta-apo-14'-carotenal
分子名称: (2E,4E,6E,8E,10E)-11-[(4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-5,9-dimethylundeca-2,4,6,8,10-pentaenal, CHLORIDE ION, COBALT (II) ION, ...
著者Daruwalla, A, Shi, W, Kiser, P.D.
登録日2019-12-20
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VCF
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BU of 6vcf by Molmil
Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase, iron form
分子名称: BICARBONATE ION, CHLORIDE ION, FE (II) ION, ...
著者Daruwalla, A, Shi, W, Kiser, P.D.
登録日2019-12-20
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.687 Å)
主引用文献Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase.
Proc.Natl.Acad.Sci.USA, 117, 2020
5J54
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BU of 5j54 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
分子名称: Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ...
著者McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
登録日2016-04-01
公開日2016-11-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6B86
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BU of 6b86 by Molmil
2.2A Crystal Structure of Co-CAO1
分子名称: COBALT (II) ION, Carotenoid oxygenase 1
著者Hill, H.E, Kiser, P.D.
登録日2017-10-05
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Preparation and characterization of metal-substituted carotenoid cleavage oxygenases.
J. Biol. Inorg. Chem., 23, 2018
5J55
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BU of 5j55 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
分子名称: 4-hydroxy-3-methoxybenzaldehyde, Carotenoid oxygenase, FE (III) ION, ...
著者McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
登録日2016-04-01
公開日2016-11-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5J53
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BU of 5j53 by Molmil
The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase
分子名称: Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ...
著者McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D.
登録日2016-04-01
公開日2016-11-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6BIG
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BU of 6big by Molmil
Crystal structure of cobalt-substituted Synechocystis ACO
分子名称: Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, COBALT (II) ION
著者Sui, X, Shi, W, Kiser, P.D.
登録日2017-11-02
公開日2018-07-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Preparation and characterization of metal-substituted carotenoid cleavage oxygenases.
J. Biol. Inorg. Chem., 23, 2018

 

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