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PDB: 60 件
1E0E
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N-terminal zinc-binding HHCC domain of HIV-2 integrase
分子名称: HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 INTEGRASE, ZINC ION
著者Eijkelenboom, A.P.A.M, Van Den ent, F.M.I, Plasterk, R.H.A, Kaptein, R, Boelens, R.
登録日2000-03-25
公開日2001-03-19
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Refined Solution Structure of the Dimeric N-Terminal Hhcc Domain of HIV-2 Integrase
J.Biomol.NMR, 18, 2000
1WJB
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BU of 1wjb by Molmil
SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, 40 STRUCTURES
分子名称: HIV-1 INTEGRASE, ZINC ION
著者Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M.
登録日1997-05-13
公開日1998-05-13
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
Nat.Struct.Biol., 4, 1997
1WJA
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SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (D FORM), NMR, REGULARIZED MEAN STRUCTURE
分子名称: HIV-1 INTEGRASE, ZINC ION
著者Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M.
登録日1997-05-13
公開日1998-05-13
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
Nat.Struct.Biol., 4, 1997
1WJF
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BU of 1wjf by Molmil
SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, 40 STRUCTURES
分子名称: CADMIUM ION, HIV-1 INTEGRASE
著者Cai, M, Gronenborn, A.M, Clore, G.M.
登録日1998-06-11
公開日1998-12-16
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium.
Protein Sci., 7, 1998
1WJE
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BU of 1wje by Molmil
SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称: CADMIUM ION, HIV-1 INTEGRASE
著者Cai, M, Gronenborn, A.M, Clore, G.M.
登録日1998-06-11
公開日1998-12-16
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium.
Protein Sci., 7, 1998
1WJD
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BU of 1wjd by Molmil
SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, 38 STRUCTURES
分子名称: HIV-1 INTEGRASE, ZINC ION
著者Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M.
登録日1997-05-13
公開日1998-05-13
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
Nat.Struct.Biol., 4, 1997
1WJC
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BU of 1wjc by Molmil
SOLUTION STRUCTURE OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE (E FORM), NMR, REGULARIZED MEAN STRUCTURE
分子名称: HIV-1 INTEGRASE, ZINC ION
著者Clore, G.M, Cai, M, Caffrey, M, Gronenborn, A.M.
登録日1997-05-13
公開日1998-05-13
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.
Nat.Struct.Biol., 4, 1997
7ZPP
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BU of 7zpp by Molmil
Cryo-EM structure of the MVV CSC intasome at 4.5A resolution
分子名称: Integrase, vDNA, non-transferred strand, ...
著者Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P.
登録日2022-04-28
公開日2022-05-11
最終更新日2022-10-12
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献A supramolecular assembly mediates lentiviral DNA integration
Science, 355, 2017
1K6Y
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Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase
分子名称: Integrase, PHOSPHATE ION, POTASSIUM ION, ...
著者Wang, J, Ling, H, Yang, W, Craigie, R.
登録日2001-10-17
公開日2001-12-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
EMBO J., 20, 2001
3JCA
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BU of 3jca by Molmil
Core model of the Mouse Mammary Tumor Virus intasome
分子名称: 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ...
著者Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N.
登録日2015-11-24
公開日2016-02-17
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5M0R
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BU of 5m0r by Molmil
Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex
分子名称: integrase, tDNA, vDNA, ...
著者Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P.
登録日2016-10-05
公開日2017-01-18
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (8.2 Å)
主引用文献A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
5U1C
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BU of 5u1c by Molmil
Structure of tetrameric HIV-1 Strand Transfer Complex Intasome
分子名称: DNA (11-MER), DNA (23-MER), DNA (37-MER), ...
著者Lyumkis, D, Passos, D.
登録日2016-11-28
公開日2017-01-11
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome.
Science, 355, 2017
7JN3
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BU of 7jn3 by Molmil
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048
分子名称: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ...
著者Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P.
登録日2020-08-03
公開日2021-03-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Commun Biol, 4, 2021
4FW2
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BU of 4fw2 by Molmil
Crystal structure of RSV three-domain integrase with disordered N-terminal domain
分子名称: Integrase
著者Shi, K, Aihara, H.
登録日2012-06-29
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding.
Plos One, 8, 2013
5CZ2
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BU of 5cz2 by Molmil
Crystal structure of a two-domain fragment of MMTV integrase
分子名称: MAGNESIUM ION, Pol polyprotein, ZINC ION
著者Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
登録日2015-07-31
公開日2016-02-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5EJK
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BU of 5ejk by Molmil
Crystal structure of the Rous sarcoma virus intasome
分子名称: DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*T)-3'), DNA (5'-D(*CP*TP*TP*CP*TP*CP*TP*C)-3'), ...
著者Yin, Z, Shi, K, Banerjee, S, Aihara, H.
登録日2015-11-02
公開日2016-02-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structure of the Rous sarcoma virus intasome.
Nature, 530, 2016
7KUI
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BU of 7kui by Molmil
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. CIC region of a cluster identified by 3-dimensional variability analysis in cryoSPARC.
分子名称: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ...
著者Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P.
登録日2020-11-25
公開日2021-03-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Commun Biol, 4, 2021
7KU7
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BU of 7ku7 by Molmil
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC.
分子名称: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ...
著者Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P.
登録日2020-11-24
公開日2021-03-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
Commun Biol, 4, 2021
5HOT
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BU of 5hot by Molmil
Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase
分子名称: (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase
著者Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D.
登録日2016-01-19
公開日2016-12-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.4 Å)
主引用文献Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
8W34
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HIV-1 intasome core assembled with wild-type integrase, 1F
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ...
著者Li, M, Craigie, R.
登録日2024-02-21
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
7UT1
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BU of 7ut1 by Molmil
Higher-order assembly of multiple MMTV strand transfer complex intasomes
分子名称: Integrase, ZINC ION, tDNA strand, ...
著者Jozwik, I, Lyumkis, D.
登録日2022-04-26
公開日2022-08-24
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献B-to-A transition in target DNA during retroviral integration.
Nucleic Acids Res., 50, 2022
7USF
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BU of 7usf by Molmil
Mouse mammary tumor virus strand transfer complex intasome
分子名称: CALCIUM ION, Integrase, ZINC ION, ...
著者Jozwik, I, Lyumkis, D.
登録日2022-04-25
公開日2022-08-24
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献B-to-A transition in target DNA during retroviral integration.
Nucleic Acids Res., 50, 2022
8W2R
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HIV-1 P5-IN intasome core
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ...
著者Li, M, Craigie, R.
登録日2024-02-21
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
8W09
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BU of 8w09 by Molmil
HIV-1 wild-type intasome core
分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ...
著者Li, M, Craigie, R.
登録日2024-02-13
公開日2024-04-17
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro.
J.Mol.Biol., 436, 2024
7SEP
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BU of 7sep by Molmil
Cryo-EM Structure of the RT component of the HIV-1 Pol Polyprotein
分子名称: Gag-Pol polyprotein
著者Lyumkis, D, Passos, D, Arnold, E, Harrison, J.J.E.
登録日2021-10-01
公開日2022-07-27
最終更新日2022-08-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation.
Sci Adv, 8, 2022

 

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