7EL6
 
 | | Structure of SMCR8 bound FEM1B | | Descriptor: | Protein fem-1 homolog B,Guanine nucleotide exchange protein SMCR8 | | Authors: | Zhao, S, Xu, C. | | Deposit date: | 2021-04-08 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.802 Å) | | Cite: | Structural insights into SMCR8 C-degron recognition by FEM1B.
Biochem.Biophys.Res.Commun., 557, 2021
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6LT0
 | | cryo-EM structure of C9ORF72-SMCR8-WDR41 | | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | | Authors: | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | | Deposit date: | 2020-01-21 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6LBF
 | | Crystal structure of FEM1B | | Descriptor: | Protein fem-1 homolog B, SULFATE ION | | Authors: | Chen, X, Liao, S, Xu, C. | | Deposit date: | 2019-11-14 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.252 Å) | | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
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8WQF
 | | cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQB
 | | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | | Descriptor: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQE
 | | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1) | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQA
 | | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) | | Descriptor: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQH
 | | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) | | Descriptor: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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7CNG
 | | Structure of CDK5R1 bound FEM1B | | Descriptor: | Protein fem-1 homolog B,Peptide from Cyclin-dependent kinase 5 activator 1, SULFATE ION | | Authors: | Chen, X, Liao, S, Xu, C. | | Deposit date: | 2020-07-31 | | Release date: | 2020-10-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase.
Nat.Chem.Biol., 17, 2021
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8WQI
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8WQC
 | | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8WQD
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8JE2
 | | Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN | | Descriptor: | Cullin-2, Elongin-B, Elongin-C, ... | | Authors: | Dai, Z, Liang, L, Yin, Y.X. | | Deposit date: | 2023-05-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.63 Å) | | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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6V4U
 | | Cryo-EM structure of SMCR8-C9orf72-WDR41 complex | | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | | Authors: | Su, M.Y, Hurley, J.H. | | Deposit date: | 2019-12-01 | | Release date: | 2020-09-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD.
Nature, 585, 2020
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7MGE
 | | Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | | Descriptor: | ADP-ribosylation factor 1, BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Su, M.-Y, Hurley, J.H. | | Deposit date: | 2021-04-12 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Structural basis for the ARF GAP activity and specificity of the C9orf72 complex.
Nat Commun, 12, 2021
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8JE1
 | | An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | Authors: | Dai, Z, Liang, L, Yin, Y.X. | | Deposit date: | 2023-05-15 | | Release date: | 2024-02-28 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.95 Å) | | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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8WQG
 | | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... | | Authors: | Chen, X, Zhang, K, Xu, C. | | Deposit date: | 2023-10-11 | | Release date: | 2024-04-03 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.09 Å) | | Cite: | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.
Nat Commun, 15, 2024
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8IJ1
 | | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | Authors: | Dai, Z, Liang, L, Yin, Y.X. | | Deposit date: | 2023-02-24 | | Release date: | 2024-02-28 | | Last modified: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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7O2W
 | | Structure of the C9orf72-SMCR8 complex | | Descriptor: | Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein, Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | | Authors: | Noerpel, J, Cavadini, S, Schenk, A.D, Graff-Meyer, A, Chao, J, Bhaskar, V. | | Deposit date: | 2021-03-31 | | Release date: | 2021-07-21 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY | | Cite: | Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture.
Plos Biol., 19, 2021
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