7UNL
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![BU of 7unl by Molmil](/molmil-images/mine/7unl) | Human TMEM175 in an open state | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-04-11 | Release date: | 2022-06-01 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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7UNM
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![BU of 7unm by Molmil](/molmil-images/mine/7unm) | Human TMEM175 in an closed state | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-04-11 | Release date: | 2022-06-29 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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6WC9
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![BU of 6wc9 by Molmil](/molmil-images/mine/6wc9) | Human open state TMEM175 in KCl | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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8DHM
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![BU of 8dhm by Molmil](/molmil-images/mine/8dhm) | Human TMEM175 in complex with 4-aminopyridine | Descriptor: | 4-AMINOPYRIDINE, Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-06-27 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175. Proc.Natl.Acad.Sci.USA, 119, 2022
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6WCA
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![BU of 6wca by Molmil](/molmil-images/mine/6wca) | Human closed state TMEM175 in KCl | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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6WCB
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![BU of 6wcb by Molmil](/molmil-images/mine/6wcb) | Human open state TMEM175 in CsCl | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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6W8N
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![BU of 6w8n by Molmil](/molmil-images/mine/6w8n) | |
6WCC
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![BU of 6wcc by Molmil](/molmil-images/mine/6wcc) | Human closed state TMEM175 in CsCl | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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8FYF
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![BU of 8fyf by Molmil](/molmil-images/mine/8fyf) | Human TMEM175-LAMP1 transmembrane domain only complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-26 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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6W8O
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![BU of 6w8o by Molmil](/molmil-images/mine/6w8o) | |
7LF6
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![BU of 7lf6 by Molmil](/molmil-images/mine/7lf6) | Structure of lysosomal membrane protein | Descriptor: | Endosomal/lysosomal potassium channel TMEM175 | Authors: | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | Deposit date: | 2021-01-15 | Release date: | 2022-01-26 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Sci Adv, 8, 2022
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8FY5
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![BU of 8fy5 by Molmil](/molmil-images/mine/8fy5) | Human TMEM175-LAMP1 full-length complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-25 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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6W8P
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![BU of 6w8p by Molmil](/molmil-images/mine/6w8p) | Structure of membrane protein with ions | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | Deposit date: | 2020-03-21 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of membrane protein with ions To Be Published
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