8DHM
Human TMEM175 in complex with 4-aminopyridine
Summary for 8DHM
Entry DOI | 10.2210/pdb8dhm/pdb |
EMDB information | 27436 |
Descriptor | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION, 4-AMINOPYRIDINE, ... (4 entities in total) |
Functional Keywords | potassium channel, ion channel, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 111585.95 |
Authors | Oh, S.,Hite, R.K. (deposition date: 2022-06-27, release date: 2022-11-23, Last modification date: 2024-06-12) |
Primary citation | Oh, S.,Stix, R.,Zhou, W.,Faraldo-Gomez, J.D.,Hite, R.K. Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175. Proc.Natl.Acad.Sci.USA, 119:e2208882119-e2208882119, 2022 Cited by PubMed: 36279431DOI: 10.1073/pnas.2208882119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.73 Å) |
Structure validation
Download full validation report