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PDB: 5 results

4RLY
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BU of 4rly by Molmil
Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain
Descriptor: Nav1.2 - AnkB chimera, SULFATE ION
Authors:Wei, Z, Wang, C, Zhang, M.
Deposit date:2014-10-18
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5032 Å)
Cite:Structural basis of diverse membrane target recognitions by ankyrins.
Elife, 3, 2014
6J8E
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BU of 6j8e by Molmil
Human Nav1.2-beta2-KIIIA ternary complex
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, X, Li, Z, Huang, X, Huang, G, Yan, N.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA.
Science, 363, 2019
4JPZ
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BU of 4jpz by Molmil
Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
Descriptor: CALCIUM ION, Calmodulin, Fibroblast growth factor 13, ...
Authors:Wang, C, Chung, B.C, Yan, H, Wang, H.G, Lee, S.Y, Pitt, G.S.
Deposit date:2013-03-19
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Nat Commun, 5, 2014
6BUT
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BU of 6but by Molmil
Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2
Descriptor: Calmodulin-1, Sodium channel protein type 2 subunit alpha
Authors:Mahling, R, Kilpatrick, A.M, Shea, M.A.
Deposit date:2017-12-11
Release date:2019-06-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Na V 1.2 EFL domain allosterically enhances Ca 2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.
Structure, 2021
2KAV
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BU of 2kav by Molmil
Solution structure of the human Voltage-gated Sodium Channel, brain isoform (Nav1.2)
Descriptor: Sodium channel protein type 2 subunit alpha
Authors:Miloushev, V.Z, Levine, J.A, Arbing, M.A, Hunt, J.F, Pitt, G.S, Palmer, A.G.
Deposit date:2008-11-15
Release date:2009-01-06
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the NaV1.2 C-terminal EF-hand domain.
J.Biol.Chem., 284, 2009

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