6BUT

Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2

Summary for 6BUT

• Entry DOI: 10.2210/pdb6but/pdb
• NMR Information: BMRB: 27095
• Descriptor: Calmodulin-1, Sodium channel protein type 2 subunit alpha (2 entities in total)
• Functional Keywords: calcium-binding protein, metal transport ion channel neuronal molecular recognition, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20403.76

Authors

Mahling, R.,Kilpatrick, A.M.,Shea, M.A. (deposition date: 2017-12-11, release date: 2019-06-19, Last modification date: 2021-04-21)

• Primary citation: Mahling, R.,Hovey, L.,Isbell, H.M.,Marx, D.C.,Miller, M.S.,Kilpatrick, A.M.,Weaver, L.D.,Yoder, J.B.,Kim, E.H.,Andresen, C.N.J.,Li, S.,Shea, M.A.; Na V 1.2 EFL domain allosterically enhances Ca 2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.; Structure, 2021; PubMed: 33770503; DOI: 10.1016/j.str.2021.03.002

Experimental method

SOLUTION NMR