6HEI
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7TUO
| Crystal structure analysis of human USP28 complex with a compound | Descriptor: | 7-amino-N-(2-{4-[(1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl]phenyl}ethyl)-3-methylthieno[2,3-b]pyrazine-6-carboxamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2022-02-03 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal Structure Analysis of human USP28 complex with a compound To Be Published
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6HEH
| Structure of the catalytic domain of USP28 (insertion deleted) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Gersch, M, Komander, D. | Deposit date: | 2018-08-20 | Release date: | 2019-03-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
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8P19
| USP28 USP domain apo | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Sauer, F, Karal Nair, R, Kisker, C. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | USP28 USP domain apo To Be Published
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8P14
| USP28 USP domain in complex with Vismodegib | Descriptor: | 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Sauer, F, Karal Nair, R, Kisker, C. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | USP28 USP domain in complex with Vismodegib To Be Published
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8P1P
| USP28 in complex with AZ1 | Descriptor: | 2-[[5-bromanyl-2-[[4-fluoranyl-3-(trifluoromethyl)phenyl]methoxy]phenyl]methylamino]ethanol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Sauer, F, Karal-Nair, R, Kisker, C. | Deposit date: | 2023-05-12 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | USP28 in complex with AZ1 To Be Published
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6HEJ
| Structure of human USP28 | Descriptor: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Gersch, M, Komander, D. | Deposit date: | 2018-08-20 | Release date: | 2019-03-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
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8P1Q
| USP28 in complex with FT206 | Descriptor: | 3-azanyl-N-[(2S)-6-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-1,2,3,4-tetrahydronaphthalen-2-yl]-6-methyl-thieno[2,3-b]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Sauer, F, Karal Nair, R, Kisker, C. | Deposit date: | 2023-05-12 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | USP28 in complex with FT206 To Be Published
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8HJE
| Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28 | Descriptor: | 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N. | Deposit date: | 2022-11-23 | Release date: | 2023-05-03 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur.J.Med.Chem., 254, 2023
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6HEK
| Structure of human USP28 bound to Ubiquitin-PA | Descriptor: | CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ... | Authors: | Gersch, M, Komander, D. | Deposit date: | 2018-08-20 | Release date: | 2019-03-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
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6H4I
| Usp28 catalytic domain apo | Descriptor: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Klemm, T.A, Sauer, F, Kisker, C. | Deposit date: | 2018-07-21 | Release date: | 2019-03-27 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol.Cell, 74, 2019
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6H4H
| Usp28 catalytic domain variant E593D in complex with UbPA | Descriptor: | Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28, ... | Authors: | Klemm, T.A, Sauer, F, Kisker, C. | Deposit date: | 2018-07-21 | Release date: | 2019-03-27 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities. Mol.Cell, 74, 2019
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2LVA
| NMR solution structure of the N-terminal domain of human USP28, Northeast structural genomics consortium target HT8470A | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 28 | Authors: | Lemak, A, Yee, A, Houliston, S, Garcia, M, Dhe-Paganon, S, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2012-06-29 | Release date: | 2012-07-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the N-terminal domain of human USP28 To be Published
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2MUU
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