8HJE

Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28

Summary for 8HJE

Entry DOI	10.2210/pdb8hje/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 28, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide (2 entities in total)
Functional Keywords	vismodegib, usp28, catalytical domain, inhibitor, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	44853.82
Authors	Shi, L.,Wang, H.,Xu, Z.,Xiong, B.,Zhang, N. (deposition date: 2022-11-23, release date: 2023-05-03)
Primary citation	Zhou, D.,Xu, Z.,Huang, Y.,Wang, H.,Zhu, X.,Zhang, W.,Song, W.,Gao, T.,Liu, T.,Wang, M.,Shi, L.,Zhang, N.,Xiong, B. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur.J.Med.Chem., 254:115369-115369, 2023 Cited by PubMed: 37075624 DOI: 10.1016/j.ejmech.2023.115369 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation