4DYN
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![BU of 4dyn by Molmil](/molmil-images/mine/4dyn) | Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-885838 Ligand Bound | Descriptor: | N-[4-chloranyl-5-[4-[[3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]piperazin-1-yl]-2-nitro-phenyl]pyridine-2-carboxamide, Nucleocapsid protein | Authors: | Lewis, H.A, Baldwin, E.T, Steinbacher, S, Maskos, K, Mortl, M, Kiefersauer, R, Edavettal, S, McDonnell, P.A, Pearce, B.C, Langley, D.R. | Deposit date: | 2012-02-29 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | To be determined To be Published
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3RO5
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![BU of 3ro5 by Molmil](/molmil-images/mine/3ro5) | Crystal structure of influenza A virus nucleoprotein with ligand | Descriptor: | Nucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]methanone | Authors: | Pearce, B.C, Edavettal, S, McDonnell, P.A, Lewis, H.A, Steinbacher, S, Baldwin, E.T, Langley, D.R, Maskos, K, Mortl, M, Kiefersauer, R. | Deposit date: | 2011-04-25 | Release date: | 2011-09-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers. Proc.Natl.Acad.Sci.USA, 108, 2011
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3ZDP
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![BU of 3zdp by Molmil](/molmil-images/mine/3zdp) | |
4DYA
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![BU of 4dya by Molmil](/molmil-images/mine/4dya) | Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-885986 Ligand Bound | Descriptor: | N-[4-chloranyl-5-[4-[[3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]piperazin-1-yl]-2-nitro-phenyl]furan-2-carboxamide, Nucleocapsid protein | Authors: | Lewis, H.A, Baldwin, E.T, Steinbacher, S, Maskos, K, Mortl, M, Kiefersauer, R, Edavettal, S, McDonnell, P.A, Pearce, B.C, Langley, D.R. | Deposit date: | 2012-02-28 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | To be determined To be Published
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6J1U
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![BU of 6j1u by Molmil](/molmil-images/mine/6j1u) | influenza virus nucleoprotein with a specific inhibitor | Descriptor: | Nucleoprotein, ~{N}-[4-[(4-~{tert}-butylphenyl)carbonylamino]phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide | Authors: | Pang, B, Zhang, W.Z, Zhang, H.M, Hao, Q. | Deposit date: | 2018-12-29 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. J.Virol., 95, 2021
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4DYB
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![BU of 4dyb by Molmil](/molmil-images/mine/4dyb) | Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-883559 Ligand Bound | Descriptor: | N-[4-chloranyl-5-[4-[[3-(2-methoxyphenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]piperazin-1-yl]-2-nitro-phenyl]thiophene-2-carboxamide, Nucleocapsid protein | Authors: | Lewis, H.A, Baldwin, E.T, Steinbacher, S, Maskos, K, Mortl, M, Kiefersauer, R, Edavettal, S, McDonnell, P.A, Pearce, B.C, Langley, D.R. | Deposit date: | 2012-02-28 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | To be determined To be Published
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4IRY
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![BU of 4iry by Molmil](/molmil-images/mine/4iry) | |
4DYP
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![BU of 4dyp by Molmil](/molmil-images/mine/4dyp) | Crystal Structure of WSN/A Influenza Nucleoprotein with BMS-831780 Ligand Bound | Descriptor: | Nucleocapsid protein, [4-(5-bromanyl-3-methyl-pyridin-2-yl)piperazin-1-yl]-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanone | Authors: | Lewis, H.A, Baldwin, E.T, Steinbacher, S, Maskos, K, Mortl, M, Kiefersauer, R, Edavettal, S, McDonnell, P.A, Pearce, B.C, Langley, D.R. | Deposit date: | 2012-02-29 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | To be determined To be Published
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5B7B
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![BU of 5b7b by Molmil](/molmil-images/mine/5b7b) | Crystal structure of Nucleoprotein-nucleozin complex | Descriptor: | Nucleoprotein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl](5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone | Authors: | Pang, B, Zhang, W.Z, Zhang, H.M, Hao, Q. | Deposit date: | 2016-06-06 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites Sci Rep, 6, 2016
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4DYT
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![BU of 4dyt by Molmil](/molmil-images/mine/4dyt) | Crystal Structure of WSN/A Influenza Nucleoprotein with Three Mutations (E53D, Y289H, Y313V) | Descriptor: | Nucleocapsid protein | Authors: | Lewis, H.A, Baldwin, E.T, Steinbacher, S, Maskos, K, Mortl, M, Kiefersauer, R, Edavettal, S, McDonnell, P.A, Pearce, B.C, Langley, D.R. | Deposit date: | 2012-02-29 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | To be determined To be Published
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3TG6
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![BU of 3tg6 by Molmil](/molmil-images/mine/3tg6) | Crystal Structure of Influenza A Virus nucleoprotein with Ligand | Descriptor: | Nucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-chloropyridin-3-yl)-5-methyl-1,2-oxazol-4-yl]methanone | Authors: | Pearce, B.C, Lewis, H.A, McDonnell, P.A, Steinbacher, S, Kiefersauer, R, Mortl, M, Maskos, K, Edavettal, S, Baldwin, E.T, Langley, D.R. | Deposit date: | 2011-08-17 | Release date: | 2012-08-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Biophysical and Structural Characterization of a Novel Class of Influenza Virus Inhibitors To be Published
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2IQH
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![BU of 2iqh by Molmil](/molmil-images/mine/2iqh) | |
5TJW
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![BU of 5tjw by Molmil](/molmil-images/mine/5tjw) | Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody | Descriptor: | NP-specific inhibitory VHH, Nucleoprotein | Authors: | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | Deposit date: | 2016-10-05 | Release date: | 2016-12-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.231 Å) | Cite: | The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment. MBio, 7, 2016
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8PZQ
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![BU of 8pzq by Molmil](/molmil-images/mine/8pzq) | Model for focused reconstruction of influenza A RNP-like particle | Descriptor: | Nucleoprotein, RNA (5'P-(UC)6-FAM3') | Authors: | Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T. | Deposit date: | 2023-07-27 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (5.3 Å) | Cite: | Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation. Sci Adv, 9, 2023
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8PZP
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![BU of 8pzp by Molmil](/molmil-images/mine/8pzp) | Model for influenza A virus helical ribonucleoprotein-like structure | Descriptor: | Nucleoprotein, RNA (5'P-(UC)6-FAM3') | Authors: | Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T. | Deposit date: | 2023-07-27 | Release date: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation. Sci Adv, 9, 2023
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6I54
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![BU of 6i54 by Molmil](/molmil-images/mine/6i54) | Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 2. | Descriptor: | Influenza virus nucleoprotein, Nucleoprotein | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-11-12 | Release date: | 2019-11-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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6I7B
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![BU of 6i7b by Molmil](/molmil-images/mine/6i7b) | Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 3. | Descriptor: | Nucleoprotein | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-11-16 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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6H9G
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![BU of 6h9g by Molmil](/molmil-images/mine/6h9g) | Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1. | Descriptor: | Nucleoprotein, Polypeptide loop | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Munier, S, Carlero, D, Naffakh, N, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-08-03 | Release date: | 2020-02-12 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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4BBL
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![BU of 4bbl by Molmil](/molmil-images/mine/4bbl) | Cryo-electron microscopy reconstruction of the helical part of influenza A virus ribonucleoprotein isolated from virions. | Descriptor: | NUCLEOPROTEIN, RNA | Authors: | Arranz, R, Coloma, R, Chichon, F.J, Conesa, J.J, Carrascosa, J.L, Valpuesta, J.M, Ortin, J, Martin-Benito, J. | Deposit date: | 2012-09-26 | Release date: | 2012-12-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (18 Å) | Cite: | The Structure of Native Influenza Virion Ribonucleoproteins Science, 338, 2012
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2YMN
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![BU of 2ymn by Molmil](/molmil-images/mine/2ymn) | Organization of the Influenza Virus Replication Machinery | Descriptor: | NUCLEOPROTEIN | Authors: | Moeller, A, Kirchdoerfer, R.N, Potter, C.S, Carragher, B, Wilson, I.A. | Deposit date: | 2012-10-09 | Release date: | 2012-12-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Organization of the Influenza Virus Replication Machinery. Science, 338, 2012
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6I85
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![BU of 6i85 by Molmil](/molmil-images/mine/6i85) | Influenza A nucleoprotein docked into the 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 5. | Descriptor: | Influenza A nucleoprotein, Nucleoprotein | Authors: | Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J. | Deposit date: | 2018-11-19 | Release date: | 2020-01-29 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism. Nat Microbiol, 5, 2020
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