Crystal Structure of Influenza A Virus nucleoprotein with Ligand

Summary for 3TG6

DescriptorNucleocapsid protein, [4-(2-chloro-4-nitrophenyl)piperazin-1-yl][3-(2-chloropyridin-3-yl)-5-methyl-1,2-oxazol-4-yl]methanone (3 entities in total)
Functional Keywordsinfluenza nucleoprotein, viral protein-inhibitor complex, viral protein/inhibitor
Biological sourceInfluenza A virus
Total number of polymer chains2
Total molecular weight114536.67
Primary citation
Edavettal, S.C.,Pearce, B.C.,Lewis, H.A.,Schneeweis, L.,Deminie, C.,Discotto, L.,Carpenter, B.,Yanchunas, J.,Langley, D.R.,Metzler, W.,Gao, M.,Poss, M.A.,Maskos, K.,Mortl, M.,Keifersauer, R.,Steinbacher, S.,Healy, M.,Phillip, T.,Zoeckler, M.,Schartman, R.,McAuliffe, B.,Minassian, B.F.,Shi, S.,Zhu, S.,Pendri, A.,Li, G.,Sinz, M.,Meanwell, N.A.,Krystal, M.,Gerritz, S.W.,Cianci, C.,Baldwin, B.T.,Bryson, J.W.,McDonnell, P.A.
Biophysical and Structural Characterization of a Novel Class of Influenza Virus Inhibitors
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28650.7%2.5%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3tg6
no rotation
Molmil generated image of 3tg6
rotated about x axis by 90°
Molmil generated image of 3tg6
rotated about y axis by 90°