9J8V
 
 | | TSWV L protein in complex with ribavirin 5-triphosphate | | Descriptor: | RIBAVIRIN TRIPHOSPHATE, RNA-directed RNA polymerase L | | Authors: | Cao, L, Wang, X. | | Deposit date: | 2024-08-21 | | Release date: | 2025-04-16 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin.
Nat.Plants, 11, 2025
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8KI6
 | | Structure of tomato spotted wilt virus L protein binding to Ribavirin | | Descriptor: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, RNA-directed RNA polymerase L | | Authors: | Cao, L, Wang, X. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-25 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin.
Nat.Plants, 11, 2025
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8KI7
 | | Structure of Tomato spotted wilt virus L protein contained endoH domain binding to 3'5'vRNA | | Descriptor: | RNA (5'-R(P*AP*CP*CP*UP*GP*AP*UP*UP*GP*CP*UP*CP*U)-3'), RNA (5'-R(P*AP*GP*AP*GP*CP*AP*AP*UP*CP*A)-3'), RNA (5'-R(P*GP*CP*AP*AP*UP*CP*AP*GP*G)-3'), ... | | Authors: | Cao, L, Wang, X. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-25 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin.
Nat.Plants, 11, 2025
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8KI8
 | | structure of Tomato spotted wilt virus L protein binding to 5'vRNA | | Descriptor: | RNA (5'-R(P*AP*GP*AP*GP*CP*AP*AP*UP*CP*A)-3'), RNA-directed RNA polymerase L | | Authors: | Cao, L, Wang, X. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-25 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin.
Nat.Plants, 11, 2025
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8KIA
 | | Tomato spotted wilt virus L protein (apo state) | | Descriptor: | RNA-directed RNA polymerase L | | Authors: | Cao, L, Wang, X. | | Deposit date: | 2023-08-23 | | Release date: | 2024-09-25 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin.
Nat.Plants, 11, 2025
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8KI9
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9QTB
 | | Apo form of the L protein from Rift Valley Fever Virus | | Descriptor: | RNA-directed RNA polymerase L | | Authors: | Kral, M, Das, A.R, Kotacka, T, Blahosova, A, Hodek, J, Konvalinka, J, Demo, G, Kozisek, M. | | Deposit date: | 2025-04-08 | | Release date: | 2025-11-12 | | Last modified: | 2025-11-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights.
Acs Infect Dis., 11, 2025
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7ALP
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7EEI
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5AMQ
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5AMR
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8R6Y
 | | Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION] | | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, MAGNESIUM ION, RNA (5'-R(*(M7G)*AP*AP*A)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription.
Nucleic Acids Res., 52, 2024
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8R6W
 | | Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING] | | Descriptor: | RNA (5'-R(*(M7G)*AP*AP*A)-3'), RNA (5'-R(*AP*CP*AP*C)-3'), RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3'), ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription.
Nucleic Acids Res., 52, 2024
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8R6U
 | | Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)] | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3'), RNA primer, ... | | Authors: | Williams, H.M, Thorkelsson, S.R, Vogel, D, Busch, C, Milewski, M, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | Deposit date: | 2023-11-23 | | Release date: | 2024-04-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural snapshots of phenuivirus cap-snatching and transcription.
Nucleic Acids Res., 52, 2024
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6Y6K
 | | Cryo-EM structure of a Phenuiviridae L protein | | Descriptor: | MAGNESIUM ION, RNA-dependent RNA polymerase | | Authors: | Vogel, D, Thorkelsson, S.R, Quemin, E, Meier, K, Kouba, T, Gogrefe, N, Busch, C, Reindl, S, Guenther, S, Cusack, S, Gruenewald, K, Rosenthal, M. | | Deposit date: | 2020-02-26 | | Release date: | 2020-04-08 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 48, 2020
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6Z8K
 | | La Crosse virus polymerase at elongation mimicking stage | | Descriptor: | La Crosse virus 3' vRNA (1-16), La Crosse virus 5' vRNA (9-16), La Crosse virus 5' vRNA 1-10, ... | | Authors: | Arragain, B, Effantin, G, Schoehn, G, Cusack, S, Malet, H. | | Deposit date: | 2020-06-02 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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6Z6B
 | | Structure of full-length La Crosse virus L protein (polymerase) | | Descriptor: | RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), ... | | Authors: | Cusack, S, Gerlach, P, Reguera, J. | | Deposit date: | 2020-05-28 | | Release date: | 2020-07-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.961 Å) | | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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6Z6G
 | | Cryo-EM structure of La Crosse virus polymerase at pre-initiation stage | | Descriptor: | 3'vRNA 1-16, 5'vRNA 1-10, 5'vRNA 9-16, ... | | Authors: | Arragain, B, Effantin, G, Gerlach, P, Reguera, J, Schoehn, G, Cusack, S, Malet, H. | | Deposit date: | 2020-05-28 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
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7ORJ
 | | La Crosse virus polymerase at transcription capped RNA cleavage stage | | Descriptor: | 5' capped RNA, ADENOSINE-5'-TRIPHOSPHATE, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORI
 | | La Crosse virus polymerase at replication late-elongation stage | | Descriptor: | La Crosse virus polymerase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORN
 | | La Crosse virus polymerase at replication initiation stage | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, La Crosse virus polymerase, MAGNESIUM ION, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORL
 | | La Crosse virus polymerase at transcription initiation stage | | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORM
 | | La Crosse virus polymerase at transcription early-elongation stage | | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORK
 | | La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (5'-D(*(GTG))-R(P*A)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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7ORO
 | | La Crosse virus polymerase at replication early-elongation stage | | Descriptor: | La Crosse virus polymerase, MAGNESIUM ION, RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3'), ... | | Authors: | Arragain, B, Durieux Trouilleton, Q, Baudin, F, Cusack, S, Schoehn, G, Malet, H. | | Deposit date: | 2021-06-06 | | Release date: | 2022-02-16 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Nat Commun, 13, 2022
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