1D1N
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![BU of 1d1n by Molmil](/molmil-images/mine/1d1n) | SOLUTION STRUCTURE OF THE FMET-TRNAFMET BINDING DOMAIN OF BECILLUS STEAROTHERMOPHILLUS TRANSLATION INITIATION FACTOR IF2 | Descriptor: | INITIATION FACTOR 2 | Authors: | Meunier, S, Spurio, S, Czisch, M, Wechselberger, R, Gueunneugues, M. | Deposit date: | 1999-09-20 | Release date: | 2000-09-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the fMet-tRNA(fMet)-binding domain of B. stearothermophilus initiation factor IF2. EMBO J., 19, 2000
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3E1Y
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![BU of 3e1y by Molmil](/molmil-images/mine/3e1y) | Crystal structure of human eRF1/eRF3 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, Eukaryotic peptide chain release factor subunit 1 | Authors: | Cheng, Z, Lim, M, Kong, C, Song, H. | Deposit date: | 2008-08-05 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural insights into eRF3 and stop codon recognition by eRF1 Genes Dev., 23, 2009
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1EFM
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![BU of 1efm by Molmil](/molmil-images/mine/1efm) | |
2FX3
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![BU of 2fx3 by Molmil](/molmil-images/mine/2fx3) | Crystal Structure Determination of E. coli Elongation Factor, Tu using a Twinned Data Set | Descriptor: | Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Heffron, S.E, Moeller, R, Jurnak, F. | Deposit date: | 2006-02-03 | Release date: | 2006-03-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Solving the structure of Escherichia coli elongation factor Tu using a twinned data set. Acta Crystallogr.,Sect.D, 62, 2006
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2RDO
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![BU of 2rdo by Molmil](/molmil-images/mine/2rdo) | 50S subunit with EF-G(GDPNP) and RRF bound | Descriptor: | 23S RIBOSOMAL RNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ... | Authors: | Gao, N, Zavialov, A.V, Ehrenberg, M, Frank, J. | Deposit date: | 2007-09-24 | Release date: | 2008-03-04 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | Specific interaction between EF-G and RRF and its implication for GTP-dependent ribosome splitting into subunits. J.Mol.Biol., 374, 2007
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6XK9
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![BU of 6xk9 by Molmil](/molmil-images/mine/6xk9) | Cereblon in complex with DDB1, CC-90009, and GSPT1 | Descriptor: | 2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Clayton, T.L, Tran, E.T, Zhu, J, Pagarigan, B.E, Matyskiela, M.E, Chamberlain, P.P. | Deposit date: | 2020-06-25 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.64 Å) | Cite: | CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood, 137, 2021
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1N0V
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![BU of 1n0v by Molmil](/molmil-images/mine/1n0v) | Crystal structure of elongation factor 2 | Descriptor: | Elongation factor 2 | Authors: | Joergensen, R, Ortiz, P.A, Carr-Schmid, A, Nissen, P, Kinzy, T.G, Andersen, G.R. | Deposit date: | 2002-10-15 | Release date: | 2002-11-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat.Struct.Biol., 10, 2003
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6RA9
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![BU of 6ra9 by Molmil](/molmil-images/mine/6ra9) | Novel structural features and post-translational modifications in eukaryotic elongation factor 1A2 from Oryctolagus cuniculus | Descriptor: | Elongation factor 1-alpha 2, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Carriles, A.A, Hermoso, J, Gago, F. | Deposit date: | 2019-04-05 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Cues for Understanding eEF1A2 Moonlighting. Chembiochem, 22, 2021
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3MMP
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![BU of 3mmp by Molmil](/molmil-images/mine/3mmp) | Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins | Descriptor: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, Elongation factor Tu 2, Elongation factor Ts, ... | Authors: | Kidmose, R.T, Vasiliev, N.N, Chetverin, A.B, Knudsen, C.R, Andersen, G.R. | Deposit date: | 2010-04-20 | Release date: | 2010-06-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins. Proc.Natl.Acad.Sci.USA, 107, 2010
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7UG7
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![BU of 7ug7 by Molmil](/molmil-images/mine/7ug7) | 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Wieland, M, Holm, M, Koller, T.O, Blanchard, S.C, Wilson, D.N. | Deposit date: | 2022-03-24 | Release date: | 2022-05-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation. Proc.Natl.Acad.Sci.USA, 119, 2022
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4V9K
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![BU of 4v9k by Molmil](/molmil-images/mine/4v9k) | 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state. | Descriptor: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | Deposit date: | 2013-04-24 | Release date: | 2014-07-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science, 340, 2013
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4V5L
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![BU of 4v5l by Molmil](/molmil-images/mine/4v5l) | The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog | Descriptor: | 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Voorhees, R.M, Schmeing, T.M, Ramakrishnan, V. | Deposit date: | 2010-09-02 | Release date: | 2014-07-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Mechanism for Activation of GTP Hydrolysis on the Ribosome. Science, 330, 2010
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3VNV
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![BU of 3vnv by Molmil](/molmil-images/mine/3vnv) | Complex structure of viral RNA polymerase II | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2012-01-18 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
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4G5G
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![BU of 4g5g by Molmil](/molmil-images/mine/4g5g) | ef-tu (Escherichia coli) complexed with nvp-ldu796 | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Palestrant, D. | Deposit date: | 2012-07-17 | Release date: | 2012-12-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Antibiotic optimization and chemical structure stabilization of thiomuracin A. J.Med.Chem., 55, 2012
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4Q7J
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![BU of 4q7j by Molmil](/molmil-images/mine/4q7j) | Complex structure of viral RNA polymerase | Descriptor: | 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu 1, ... | Authors: | Takeshita, D. | Deposit date: | 2014-04-25 | Release date: | 2014-08-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Molecular insights into replication initiation by Q beta replicase using ribosomal protein S1. Nucleic Acids Res., 42, 2014
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4FWT
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![BU of 4fwt by Molmil](/molmil-images/mine/4fwt) | Complex structure of viral RNA polymerase form III | Descriptor: | CALCIUM ION, Elongation factor Ts, Elongation factor Tu, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2012-07-02 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
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5HXB
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![BU of 5hxb by Molmil](/molmil-images/mine/5hxb) | Cereblon in complex with DDB1, CC-885, and GSPT1 | Descriptor: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | Deposit date: | 2016-01-30 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535, 2016
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7N2C
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![BU of 7n2c by Molmil](/molmil-images/mine/7n2c) | Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-28 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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7N2V
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![BU of 7n2v by Molmil](/molmil-images/mine/7n2v) | Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C. | Deposit date: | 2021-05-29 | Release date: | 2021-07-14 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Structural basis of early translocation events on the ribosome. Nature, 595, 2021
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5I4Q
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![BU of 5i4q by Molmil](/molmil-images/mine/5i4q) | Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (domains 2 and 3) | Descriptor: | CHLORIDE ION, Contact-dependent inhibitor A, Contact-dependent inhibitor I, ... | Authors: | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | Deposit date: | 2016-02-12 | Release date: | 2017-06-28 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs. Nucleic Acids Res., 45, 2017
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3VNU
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![BU of 3vnu by Molmil](/molmil-images/mine/3vnu) | Complex structure of viral RNA polymerase I | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Elongation factor Ts, ... | Authors: | Takeshita, D, Tomita, K. | Deposit date: | 2012-01-18 | Release date: | 2012-08-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase Structure, 20, 2012
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4R71
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![BU of 4r71 by Molmil](/molmil-images/mine/4r71) | Structure of the Qbeta holoenzyme complex in the P1211 crystal form | Descriptor: | 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu, ... | Authors: | Gytz, H, Seweryn, P, Kutlubaeva, Z, Chetverin, A.B, Brodersen, D.E, Knudsen, C.R. | Deposit date: | 2014-08-26 | Release date: | 2015-09-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for RNA-genome recognition during bacteriophage Q beta replication. Nucleic Acids Res., 43, 2015
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2XEX
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![BU of 2xex by Molmil](/molmil-images/mine/2xex) | crystal structure of Staphylococcus aureus elongation factor G | Descriptor: | CHLORIDE ION, ELONGATION FACTOR G, POTASSIUM ION | Authors: | Chen, Y, Koripella, R.K, Sanyal, S, Selmer, M. | Deposit date: | 2010-05-19 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Staphylococcus Aureus Elongation Factor G - Structure and Analysis of a Target for Fusidic Acid. FEBS J., 277, 2010
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2YWH
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![BU of 2ywh by Molmil](/molmil-images/mine/2ywh) | Crystal structure of GDP-bound LepA from Aquifex aeolicus | Descriptor: | GTP-binding protein LepA, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Kawazoe, M, Takemoto, C, Kaminishi, T, Nishino, A, Nakayama-Ushikoshi, R, Hanawa-Suetsugu, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-20 | Release date: | 2008-04-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Crystal structures of GTP-binding protein LepA from Aquifex aeolicus. To be Published
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5WFS
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![BU of 5wfs by Molmil](/molmil-images/mine/5wfs) | |