5I4Q
 
 | | Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (domains 2 and 3) | | Descriptor: | CHLORIDE ION, Contact-dependent inhibitor A, Contact-dependent inhibitor I, ... | | Authors: | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | | Deposit date: | 2016-02-12 | | Release date: | 2017-06-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs.
Nucleic Acids Res., 45, 2017
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3E20
 | | Crystal structure of S.pombe eRF1/eRF3 complex | | Descriptor: | Eukaryotic peptide chain release factor GTP-binding subunit, Eukaryotic peptide chain release factor subunit 1 | | Authors: | Cheng, Z, Lim, M, Kong, C, Song, H. | | Deposit date: | 2008-08-05 | | Release date: | 2009-05-19 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural insights into eRF3 and stop codon recognition by eRF1
Genes Dev., 23, 2009
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5OPD
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7O9K
 | | Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1, the MALSU module, GTPBP5 and mtEF-Tu | | Descriptor: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | | Authors: | Valentin Gese, G, Hallberg, B.M. | | Deposit date: | 2021-04-16 | | Release date: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for late maturation steps of the human mitoribosomal large subunit.
Nat Commun, 12, 2021
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5I4R
 | | Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (trypsin-modified) | | Descriptor: | Contact-dependent inhibitor A, Contact-dependent inhibitor I, Elongation factor Tu, ... | | Authors: | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | | Deposit date: | 2016-02-12 | | Release date: | 2017-06-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs.
Nucleic Acids Res., 45, 2017
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4H9G
 | | Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket | | Descriptor: | 5-bromofuran-2-carboxylic acid, AMMONIUM ION, Elongation factor Tu-A, ... | | Authors: | Groftehauge, M.K, Therkelsen, M, Taaning, R.H, Skrydstrup, T, Morth, J.P, Nissen, P. | | Deposit date: | 2012-09-24 | | Release date: | 2013-09-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Identifying ligand-binding hot spots in proteins using brominated fragments.
Acta Crystallogr.,Sect.F, 69, 2013
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1HA3
 | | ELONGATION FACTOR TU IN COMPLEX WITH aurodox | | Descriptor: | BETA-MERCAPTOETHANOL, ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Vogeley, L, Palm, G.J, Mesters, J.R, Hilgenfeld, R. | | Deposit date: | 2001-03-26 | | Release date: | 2001-05-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Conformational Change of Elongation Factor TU Induced by Antibiotic Binding: Crystal Structure of the Complex between EF-TU:Gdp and Aurodox
J.Biol.Chem., 276, 2001
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6EZE
 | | The open conformation of E.coli Elongation Factor Tu in complex with GDPNP. | | Descriptor: | DI(HYDROXYETHYL)ETHER, Elongation factor Tu 2, GLYCEROL, ... | | Authors: | Johansen, J.S, Blaise, M, Thirup, S.S. | | Deposit date: | 2017-11-15 | | Release date: | 2018-08-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form.
Nucleic Acids Res., 46, 2018
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6MIJ
 | | Crystal structure of EF-Tu from Acinetobacter baumannii in complex with Mg2+ and GDP | | Descriptor: | Elongation factor Tu, FORMIC ACID, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Stogios, P.J, Evdokimova, E, Tan, K, Di Leo, R, Savchenko, A, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2018-09-19 | | Release date: | 2018-10-03 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.955 Å) | | Cite: | To be published
To Be Published
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8V9L
 | | Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6) | | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ... | | Authors: | Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G. | | Deposit date: | 2023-12-08 | | Release date: | 2024-02-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
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1AIP
 | | EF-TU EF-TS COMPLEX FROM THERMUS THERMOPHILUS | | Descriptor: | ELONGATION FACTOR TS, ELONGATION FACTOR TU | | Authors: | Wang, Y, Jiang, Y, Meyering-Voss, M, Sprinzl, M, Sigler, P.B. | | Deposit date: | 1997-04-22 | | Release date: | 1997-10-22 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus.
Nat.Struct.Biol., 4, 1997
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5JBQ
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3MMP
 | | Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins | | Descriptor: | (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, Elongation factor Tu 2, Elongation factor Ts, ... | | Authors: | Kidmose, R.T, Vasiliev, N.N, Chetverin, A.B, Knudsen, C.R, Andersen, G.R. | | Deposit date: | 2010-04-20 | | Release date: | 2010-06-09 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.
Proc.Natl.Acad.Sci.USA, 107, 2010
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4CRN
 | | Cryo-EM of a pretermination complex with eRF1 and eRF3 | | Descriptor: | ERF1 IN RIBOSOME-BOUND ERF1-ERF3-GDPNP COMPLEX, ERF3 IN RIBOSOME BOUND ERF1-ERF3-GDPNP COMPLEX, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Preis, A, Heuer, A, Barrio-Garcia, C, Hauser, A, Eyler, D, Berninghausen, O, Green, R, Becker, T, Beckmann, R. | | Deposit date: | 2014-02-28 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1.
Cell Rep., 8, 2014
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4Q7J
 | | Complex structure of viral RNA polymerase | | Descriptor: | 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu 1, ... | | Authors: | Takeshita, D. | | Deposit date: | 2014-04-25 | | Release date: | 2014-08-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Molecular insights into replication initiation by Q beta replicase using ribosomal protein S1.
Nucleic Acids Res., 42, 2014
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7ABZ
 | | Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome. | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | | Deposit date: | 2020-09-09 | | Release date: | 2021-08-18 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structures of tmRNA and SmpB as they transit through the ribosome.
Nat Commun, 12, 2021
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7PAK
 | | 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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8YLY
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7PAJ
 | | 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Xue, L, Lenz, S, Rappsilber, J, Mahamid, J. | | Deposit date: | 2021-07-30 | | Release date: | 2022-05-25 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Visualizing translation dynamics at atomic detail inside a bacterial cell.
Nature, 610, 2022
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8YM3
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4R71
 | | Structure of the Qbeta holoenzyme complex in the P1211 crystal form | | Descriptor: | 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu, ... | | Authors: | Gytz, H, Seweryn, P, Kutlubaeva, Z, Chetverin, A.B, Brodersen, D.E, Knudsen, C.R. | | Deposit date: | 2014-08-26 | | Release date: | 2015-09-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.21 Å) | | Cite: | Structural basis for RNA-genome recognition during bacteriophage Q beta replication.
Nucleic Acids Res., 43, 2015
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4ZV4
 | | Structure of Tse6 in complex with EF-Tu | | Descriptor: | Elongation factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Whitney, J.C, Sawai, S, Robinson, H, Mougous, J.D. | | Deposit date: | 2015-05-18 | | Release date: | 2015-11-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.504 Å) | | Cite: | An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells.
Cell, 163, 2015
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7A5G
 | | Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA | | Descriptor: | 12S rRNA, 16S rRNA, 28S ribosomal protein S10, ... | | Authors: | Desai, N, Yang, H, Chandrasekaran, V, Kazi, R, Minczuk, M, Ramakrishnan, V. | | Deposit date: | 2020-08-21 | | Release date: | 2020-12-23 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.33 Å) | | Cite: | Elongational stalling activates mitoribosome-associated quality control.
Science, 370, 2020
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2BVN
 | | E. coli EF-Tu:GDPNP in complex with the antibiotic enacyloxin IIa | | Descriptor: | ELONGATION FACTOR TU, ENACYLOXIN IIA, MAGNESIUM ION, ... | | Authors: | Parmeggiani, A, Krab, I.M, Watanabe, T, Nielsen, R.C, Dahlberg, C, Nyborg, J, Nissen, P. | | Deposit date: | 2005-06-30 | | Release date: | 2005-09-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Enacyloxin Iia Pinpoints a Binding Pocket of Elongation Factor TU for Development of Novel Antibiotics.
J.Biol.Chem., 281, 2006
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5AFI
 | | 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Fischer, N, Neumann, P, Konevega, A.L, Bock, L.V, Ficner, R, Rodnina, M.V, Stark, H. | | Deposit date: | 2015-01-22 | | Release date: | 2015-03-11 | | Last modified: | 2025-03-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of the E. coli ribosome-EF-Tu complex at <3 angstrom resolution by Cs-corrected cryo-EM.
Nature, 520, 2015
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