4GYV
 
 | | Crystal structure of the DH domain of FARP2 | | Descriptor: | FERM, RhoGEF and pleckstrin domain-containing protein 2 | | Authors: | He, X, Zhang, X. | | Deposit date: | 2012-09-05 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2.
Structure, 21, 2013
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2KR9
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4D0O
 | | AKAP13 (AKAP-Lbc) DH domain | | Descriptor: | A-KINASE ANCHOR PROTEIN 13 | | Authors: | Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. | | Deposit date: | 2014-04-29 | | Release date: | 2014-05-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
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8C7D
 | | Structure of the GEF Kalirin DH2 Domain | | Descriptor: | Kalirin | | Authors: | Callens, M.C, Thompson, A.P, Gray, J.L, Bountra, C, von Delft, F, Brennan, P.E. | | Deposit date: | 2023-01-14 | | Release date: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure-based alignment and analysis of RHO selectivity of RHO-DBL GTPase exchange factors
to be published
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1BY1
 | | DBL homology domain from beta-PIX | | Descriptor: | PROTEIN (PIX) | | Authors: | Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. | | Deposit date: | 1998-10-22 | | Release date: | 1999-10-24 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure and Mutagenesis of the Dbl Homology Domain
Nat.Struct.Biol., 5, 1998
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1F5X
 | | NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN | | Descriptor: | RHO-GEF VAV | | Authors: | Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. | | Deposit date: | 2000-06-18 | | Release date: | 2000-09-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell(Cambridge,Mass.), 102, 2000
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3EO2
 | | Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein | | Descriptor: | Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION | | Authors: | Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-09-26 | | Release date: | 2008-10-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein
To be Published
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5N7E
 | | Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4). | | Descriptor: | Breakpoint cluster region protein, Mb(Bcr-DH_4) | | Authors: | Reckel, S, Reynaud, A, Pojer, F, Hantschel, O. | | Deposit date: | 2017-02-20 | | Release date: | 2017-12-27 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.647 Å) | | Cite: | Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
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5N6R
 | | Solution structure of the Dbl-homology domain of Bcr-Abl | | Descriptor: | Breakpoint cluster region protein | | Authors: | Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O. | | Deposit date: | 2017-02-16 | | Release date: | 2017-12-27 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
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1TXD
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2Z0Q
 | | Crystal structure of DH-PH domain of RhoGEF3(Xpln) | | Descriptor: | Rho guanine nucleotide exchange factor 3, SULFATE ION | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-07 | | Release date: | 2008-05-13 | | Last modified: | 2012-12-12 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structure of the Rho-specific guanine nucleotide-exchange factor Xpln
Acta Crystallogr.,Sect.F, 68, 2012
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3GF9
 | | Crystal structure of human Intersectin 2 RhoGEF domain | | Descriptor: | Intersectin 2, UNKNOWN ATOM OR ION | | Authors: | Shen, Y, Tong, Y, Tempel, W, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2009-02-26 | | Release date: | 2009-03-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
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4MT7
 | | Crystal structure of collybistin I | | Descriptor: | Rho guanine nucleotide exchange factor 9 | | Authors: | Schneeberger, D, Schindelin, H. | | Deposit date: | 2013-09-19 | | Release date: | 2014-08-13 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | A conformational switch in collybistin determines the differentiation of inhibitory postsynapses.
Embo J., 33, 2014
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4MT6
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1DBH
 | | DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 | | Descriptor: | PROTEIN (HUMAN SOS 1) | | Authors: | Soisson, S.M, Kuriyan, J. | | Deposit date: | 1998-12-17 | | Release date: | 1998-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.
Cell(Cambridge,Mass.), 95, 1998
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1RJ2
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5HZI
 | | Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain | | Descriptor: | FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 | | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | | Deposit date: | 2016-02-02 | | Release date: | 2016-12-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
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5HZJ
 | | Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain | | Descriptor: | FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 | | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | | Deposit date: | 2016-02-02 | | Release date: | 2016-12-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
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5HZK
 | | Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain in complex with Cdc42 | | Descriptor: | Cell division control protein 42 homolog, FLAVIN MONONUCLEOTIDE, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. | | Deposit date: | 2016-02-02 | | Release date: | 2016-12-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Engineering extrinsic disorder to control protein activity in living cells.
Science, 354, 2016
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3ODX
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3ODO
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3ODW
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3P6A
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6NF1
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2RGN
 | | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | | Authors: | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | | Deposit date: | 2007-10-04 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
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