6I57
 
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2BUG
 | | Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide | | Descriptor: | HSP90, SERINE/THREONINE PROTEIN PHOSPHATASE 5 | | Authors: | Cliff, M.J, Harris, R, Barford, D, Ladbury, J.E, Williams, M.A. | | Deposit date: | 2005-06-13 | | Release date: | 2006-03-16 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Conformational Diversity in the Tpr Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90.
Structure, 14, 2006
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6ZBK
 | | Crystal structure of the human complex between RPAP3 and TRBP | | Descriptor: | RISC-loading complex subunit TARBP2, RNA polymerase II-associated protein 3 | | Authors: | Charron, C, Abel, Y, Charpentier, B, Rederstorff, M. | | Deposit date: | 2020-06-08 | | Release date: | 2021-06-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | The interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity.
Nucleic Acids Res., 50, 2022
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4CGV
 | | First TPR of Spaghetti (RPAP3) bound to HSP90 peptide SRMEEVD | | Descriptor: | GLYCEROL, HEAT SHOCK PROTEIN HSP 90-ALPHA, RNA POLYMERASE II-ASSOCIATED PROTEIN 3 | | Authors: | Roe, S.M, Pal, M. | | Deposit date: | 2013-11-26 | | Release date: | 2014-05-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1.
Structure, 22, 2014
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6FD7
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4GCO
 | | Central domain of stress-induced protein-1 (STI-1) from C.elegans | | Descriptor: | Protein STI-1 | | Authors: | Osipiuk, J, Bigelow, L, Gu, M, Van Oosten-Hawle, P, Morimoto, R.I, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2012-07-30 | | Release date: | 2012-08-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Central domain of stress-induced protein-1 (STI-1) from C.elegans
To be Published
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2KC7
 | | Solution NMR structure of Bacteroides fragilis protein BF1650. Northeast Structural Genomics Consortium target BfR218 | | Descriptor: | bfr218_protein | | Authors: | Eletsky, A, Wu, Y, Sukumaran, D, Lee, H, Lee, D.Y, Jiang, M, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2008-12-17 | | Release date: | 2009-01-13 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution NMR structure of Bacteroides fragilis protein BF1650. Northeast Structural Genomics Consortium target BfR218
To be Published
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2LNI
 | | Solution NMR Structure of Stress-induced-phosphoprotein 1 STI1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4403E | | Descriptor: | Stress-induced-phosphoprotein 1 | | Authors: | Tang, Y, Liu, G, Hamilton, K, Ciccosanti, C, Shastry, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2011-12-28 | | Release date: | 2012-03-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Northeast Structural Genomics Consortium Target HR4403E
To be Published
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3UPV
 | | TPR2B-domain:pHsp70-complex of yeast Sti1 | | Descriptor: | Heat shock protein SSA4, Heat shock protein STI1 | | Authors: | Schmid, A.B, Lagleder, S, Graewert, M.A, Roehl, A, Hagn, F, Wandinger, S.K, Cox, M.B, Demmer, O, Richter, K, Groll, M, Kessler, H. | | Deposit date: | 2011-11-18 | | Release date: | 2012-01-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Embo J., 31, 2012
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5LYP
 | | Crystal structure of the Tpr Domain of Sgt2. | | Descriptor: | BORATE ION, Small glutamine-rich tetratricopeptide repeat-containing protein 2 | | Authors: | Krysztofinska, E.M, Morgan, R.M.L, Thapaliya, A, Evans, N.J, Murray, J.W, Martinez-Lumbreras, S, Isaacson, R.L. | | Deposit date: | 2016-09-28 | | Release date: | 2017-10-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017
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5LYN
 | | Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment | | Descriptor: | PRO-THR-VAL-GLU-GLU-VAL-ASP, Small glutamine-rich tetratricopeptide repeat-containing protein 2, ZINC ION | | Authors: | Krysztofinska, E.M, Evans, N.J, Thapaliya, A, Murray, J.W, Morgan, R.M.L, Martinez-Lumbreras, S, Isaacson, R.L. | | Deposit date: | 2016-09-28 | | Release date: | 2017-10-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017
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7DHG
 | | Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 | | Descriptor: | Mitochondrial import receptor subunit TOM70, ORF9b protein | | Authors: | Gao, X, Zhu, K, Qin, B, Olieric, V, Wang, M, Cui, S. | | Deposit date: | 2020-11-14 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions.
Nat Commun, 12, 2021
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4RG9
 | | Crystal structure of APC3-APC16 complex (Selenomethionine Derivative) | | Descriptor: | Anaphase-promoting complex subunit 16, Cell division cycle protein 27 homolog | | Authors: | Yamaguchi, M, Yu, S, Miller, D.J, Schulman, B.A. | | Deposit date: | 2014-09-29 | | Release date: | 2014-12-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structure of an APC3-APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome.
J.Mol.Biol., 427, 2015
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1ELR
 | | Crystal structure of the TPR2A domain of HOP in complex with the HSP90 peptide MEEVD | | Descriptor: | HSP90-PEPTIDE MEEVD, NICKEL (II) ION, TPR2A-DOMAIN OF HOP | | Authors: | Scheufler, C, Brinker, A, Hartl, F.U, Moarefi, I. | | Deposit date: | 2000-03-14 | | Release date: | 2000-04-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine.
Cell(Cambridge,Mass.), 101, 2000
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8PKP
 | | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | | Deposit date: | 2023-06-27 | | Release date: | 2023-07-19 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures of apo-APC/C and APC/C CDH1:EMI1 complexes provide insights into APC/C regulation.
Nat Commun, 15, 2024
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3IEG
 | | Crystal Structure of P58(IPK) TPR Domain at 2.5 A | | Descriptor: | DnaJ homolog subfamily C member 3 | | Authors: | Tao, J, Sha, B. | | Deposit date: | 2009-07-22 | | Release date: | 2010-03-31 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Crystal Structure of P58(IPK) TPR Fragment Reveals the Mechanism for its Molecular Chaperone Activity in UPR.
J.Mol.Biol., 64, 2010
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2GW1
 | | Crystal Structure of the Yeast Tom70 | | Descriptor: | Mitochondrial precursor proteins import receptor | | Authors: | Wu, Y, Sha, B. | | Deposit date: | 2006-05-03 | | Release date: | 2006-06-27 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p.
Nat.Struct.Mol.Biol., 13, 2006
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2VYI
 | | Crystal Structure of the TPR domain of Human SGT | | Descriptor: | SGTA PROTEIN | | Authors: | Dutta, S, Tan, Y.J. | | Deposit date: | 2008-07-24 | | Release date: | 2008-08-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Functional Characterization of Human Sgt and its Interaction with Vpu of the Human Immunodeficiency Virus Type 1.
Biochemistry, 47, 2008
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3FP4
 | | Crystal structure of Tom71 complexed with Ssa1 C-terminal fragment | | Descriptor: | CHLORIDE ION, SODIUM ION, SULFATE ION, ... | | Authors: | Li, J, Qian, X, Hu, J, Sha, B. | | Deposit date: | 2009-01-03 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.
J.Biol.Chem., 284, 2009
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7AI4
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3FWV
 | | Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide | | Descriptor: | Heat shock protein HSP 90-beta, Hsc70/Hsp90-organizing protein, NICKEL (II) ION | | Authors: | Jackrel, M.E, Valverde, R, Regan, L. | | Deposit date: | 2009-01-19 | | Release date: | 2009-04-21 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Redesign of a protein-peptide interaction: characterization and applications
Protein Sci., 18, 2009
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7AIE
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4GCN
 | | N-terminal domain of stress-induced protein-1 (STI-1) from C.elegans | | Descriptor: | Protein STI-1, TRIETHYLENE GLYCOL | | Authors: | Osipiuk, J, Bigelow, L, Gu, M, Van Oosten-Hawle, P, Morimoto, R.I, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2012-07-30 | | Release date: | 2012-08-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | N-terminal domain of stress-induced protein-1 (STI-1) from C.elegans
To be Published
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6FO1
 | | Human R2TP subcomplex containing 1 RUVBL1-RUVBL2 hexamer bound to 1 RBD domain from RPAP3. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RNA polymerase II-associated protein 3, RuvB-like 1, ... | | Authors: | Martino, F, Munoz-Hernandez, H, Rodriguez, C.F, Pearl, L.H, Llorca, O. | | Deposit date: | 2018-02-05 | | Release date: | 2018-04-04 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
Nat Commun, 9, 2018
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7NTF
 | | Cryo-EM structure of unliganded O-GlcNAc transferase | | Descriptor: | Isoform 1 of UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | | Authors: | Meek, R.W, Blaza, J.N, Davies, G.J. | | Deposit date: | 2021-03-09 | | Release date: | 2021-11-17 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (5.32 Å) | | Cite: | Cryo-EM structure provides insights into the dimer arrangement of the O-linked beta-N-acetylglucosamine transferase OGT.
Nat Commun, 12, 2021
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