8GJI
 
 | | De novo design of high-affinity protein binders to bioactive helical peptides | | Descriptor: | GCG binder, Glucagon | | Authors: | Torres, S.V, Leung, P.J.Y, Bera, A.K, Baker, D, Kang, A. | | Deposit date: | 2023-03-15 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | De novo design of high-affinity binders of bioactive helical peptides.
Nature, 626, 2024
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7XM8
 | | Glucagon amyloid fibril | | Descriptor: | Glucagon | | Authors: | Jeong, H, Lin, Y, Lee, Y.-H. | | Deposit date: | 2022-04-25 | | Release date: | 2023-04-19 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Atomistic zipper-like amyloid structure of full-length glucagon
To Be Published
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1NAU
 | | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles | | Descriptor: | Glucagon | | Authors: | Ying, J, Ahn, J.-M, Jacobsen, N.E, Brown, M.F, Hruby, V.J. | | Deposit date: | 2002-11-28 | | Release date: | 2003-03-18 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles
Biochemistry, 42, 2003
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1T5Q
 | | Solution Structure of GIP(1-30)amide in TFE/Water | | Descriptor: | Gastric inhibitory polypeptide | | Authors: | Alana, I, Hewage, C.M, Malthouse, J.P.G, Parker, J.C, Gault, V.A, O'Harte, F.P.M. | | Deposit date: | 2004-05-05 | | Release date: | 2004-11-16 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.
Biochem.Biophys.Res.Commun., 325, 2004
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4APD
 | | Liraglutide | | Descriptor: | LIRAGLUTIDE, N-hexadecanoyl-L-glutamic acid | | Authors: | Ludvigsen, S, Steensgaard, D.B, Thomsen, J.K, Strauss, H, Normann, M. | | Deposit date: | 2012-04-02 | | Release date: | 2013-07-10 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | Liraglutide
To be Published
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6GDZ
 | | exendin-4 based dual GLP-1/glucagon receptor agonist | | Descriptor: | (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4 | | Authors: | Evers, A, Kurz, M. | | Deposit date: | 2018-04-25 | | Release date: | 2018-06-20 | | Last modified: | 2025-04-09 | | Method: | SOLUTION NMR | | Cite: | Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
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2D2P
 | | The solution structure of micelle-bound peptide | | Descriptor: | Pituitary adenylate cyclase activating polypeptide-38 | | Authors: | Tateishi, Y, Jee, J.G, Inooka, H, Tochio, H, Hiroaki, H, Shirakawa, M. | | Deposit date: | 2005-09-14 | | Release date: | 2006-09-26 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | The solution structure of micelle-bound peptide
To be Published
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6GE2
 | | exendin-4 based dual GLP-1/glucagon receptor agonist | | Descriptor: | (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid, Exendin-4 | | Authors: | Evers, A, Kurz, M. | | Deposit date: | 2018-04-25 | | Release date: | 2018-06-20 | | Last modified: | 2025-04-09 | | Method: | SOLUTION NMR | | Cite: | Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
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1BH0
 | | STRUCTURE OF A GLUCAGON ANALOG | | Descriptor: | GLUCAGON | | Authors: | Sturm, N.S, Lin, Y, Burley, S.K, Krstenansky, J.L, Ahn, J.-M, Azizeh, B.Y, Trivedi, D, Hruby, V.J. | | Deposit date: | 1998-06-11 | | Release date: | 1998-11-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity.
J.Med.Chem., 41, 1998
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1GEA
 | | RECEPTOR-BOUND CONFORMATION OF PACAP21 | | Descriptor: | PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE | | Authors: | Inooka, H, Ohtaki, T, Kitahara, O, Ikegami, T, Endo, S, Kitada, C, Ogi, K, Onda, H, Fujino, M, Shirakawa, M. | | Deposit date: | 2000-10-20 | | Release date: | 2001-04-20 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Conformation of a peptide ligand bound to its G-protein coupled receptor.
Nat.Struct.Biol., 8, 2001
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1KX6
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1GCN
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6NZN
 | | Dimer-of-dimer amyloid fibril structure of glucagon | | Descriptor: | Glucagon | | Authors: | Gelenter, M.D, Smith, K.J, Liao, S.Y, Mandala, V.S, Dregni, A.J, Lamm, M.S, Tian, Y, Wei, X, Pochan, D.J, Tucker, T.J, Su, Y, Hong, M. | | Deposit date: | 2019-02-14 | | Release date: | 2019-06-05 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | The peptide hormone glucagon forms amyloid fibrils with two coexisting beta-strand conformations.
Nat.Struct.Mol.Biol., 26, 2019
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1JRJ
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2B4N
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1D0R
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2L64
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2L63
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2RRI
 | | NMR structure of vasoactive intestinal peptide in DPC Micelle | | Descriptor: | Vasoactive intestinal peptide | | Authors: | Umetsu, Y, Tenno, T, Goda, N, Shirakawa, M, Ikegami, T, Hiroaki, H. | | Deposit date: | 2010-12-21 | | Release date: | 2011-04-06 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments
Biochim.Biophys.Acta, 1814, 2011
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2L71
 | | NMR solution structure of GIP in Bicellular media | | Descriptor: | Gastric inhibitory polypeptide | | Authors: | Venneti, K.C, Alana, I, O'Harte, F.P.M, Malthouse, P.J.G, Hewage, C.M. | | Deposit date: | 2010-12-01 | | Release date: | 2011-10-19 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide
Biochim.Biophys.Acta, 1814, 2011
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2RRH
 | | NMR structure of vasoactive intestinal peptide in Methanol | | Descriptor: | VIP peptides | | Authors: | Umetsu, Y, Tenno, T, Goda, N, Ikegami, T, Hiroaki, H. | | Deposit date: | 2010-11-12 | | Release date: | 2011-04-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments.
Biochim.Biophys.Acta, 1814, 2011
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7MLL
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5NIQ
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2L70
 | | NMR solution structure of GIP in micellular media | | Descriptor: | Gastric inhibitory polypeptide | | Authors: | Venneti, K.C, Alana, I, O'Harte, F.P.M, Malthouse, P.J.G, Hewage, C.M. | | Deposit date: | 2010-12-01 | | Release date: | 2011-10-19 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide
Biochim.Biophys.Acta, 1814, 2011
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6PHK
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