5NIQ

exendin-4 variant with dual GLP-1 / glucagon receptor activity

Summary for 5NIQ

• Entry DOI: 10.2210/pdb5niq/pdb
• NMR Information: BMRB: 34119
• Descriptor: Exendin-4, N-hexadecanoyl-L-glutamic acid (2 entities in total)
• Functional Keywords: exendin-4 analogue, dual glp-1 / glucagon agonist, hormone
• Biological source: Heloderma suspectum (Gila monster)
• Total number of polymer chains: 1
• Total formula weight: 4605.10

Authors

Evers, A.,Kurz, M. (deposition date: 2017-03-24, release date: 2018-02-28, Last modification date: 2023-06-14)

• Primary citation: Evers, A.,Haack, T.,Lorenz, M.,Bossart, M.,Elvert, R.,Henkel, B.,Stengelin, S.,Kurz, M.,Glien, M.,Dudda, A.,Lorenz, K.,Kadereit, D.,Wagner, M.; Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.; J.Med.Chem., 60:4293-4303, 2017; PubMed: 28448133; DOI: 10.1021/acs.jmedchem.7b00174

Experimental method

SOLUTION NMR