6GDZ

exendin-4 based dual GLP-1/glucagon receptor agonist

Summary for 6GDZ

• Entry DOI: 10.2210/pdb6gdz/pdb
• NMR Information: BMRB: 34264
• Descriptor: Exendin-4, (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid (2 entities in total)
• Functional Keywords: hormone
• Biological source: Heloderma suspectum (Gila monster)
• Total number of polymer chains: 1
• Total formula weight: 4657.24

Authors

Evers, A.,Kurz, M. (deposition date: 2018-04-25, release date: 2018-06-20, Last modification date: 2019-05-08)

• Primary citation: Evers, A.,Bossart, M.,Pfeiffer-Marek, S.,Elvert, R.,Schreuder, H.,Kurz, M.,Stengelin, S.,Lorenz, M.,Herling, A.,Konkar, A.,Lukasczyk, U.,Pfenninger, A.,Lorenz, K.,Haack, T.,Kadereit, D.,Wagner, M.; Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.; J. Med. Chem., 61:5580-5593, 2018; PubMed: 29879354; DOI: 10.1021/acs.jmedchem.8b00292

Experimental method

SOLUTION NMR