6GDZ
exendin-4 based dual GLP-1/glucagon receptor agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Exendin-4 | polymer | 40 | 4142.6 | 1 | UniProt (P26349) Pfam (PF00123) | Heloderma suspectum | |
| 2 | B (A) | (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid | non-polymer | 514.7 | 1 | Chemie (EVT) |
Sequence modifications
A: 1 - 39 (UniProt: P26349)
| PDB | External Database | Details |
|---|---|---|
| Aib 2 | Gly 49 | conflict |
| Gln 3 | Glu 50 | conflict |
| Lys 14 | Met 61 | conflict |
| Asp 15 | Glu 62 | conflict |
| Gln 17 | Glu 64 | conflict |
| Arg 18 | Ala 65 | conflict |
| Ala 19 | Val 66 | conflict |
| Lys 20 | Arg 67 | conflict |
| Aib 27 | Lys 74 | conflict |
| Ala 28 | Asn 75 | conflict |
| Nh2 40 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 4142.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 514.7 | |
| All* | Total formula weight | 4657.2 |
