4TPI
 
 | | THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR | | Descriptor: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | | Authors: | Bode, W, Walter, J. | | Deposit date: | 1985-06-11 | | Release date: | 1985-11-08 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
Eur.J.Biochem., 144, 1984
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5NX1
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | Deposit date: | 2017-05-09 | | Release date: | 2018-05-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.853 Å) | | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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4ISN
 | | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | | Descriptor: | GLUTATHIONE, Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, ... | | Authors: | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | Deposit date: | 2013-01-16 | | Release date: | 2013-03-06 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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4ISL
 | | Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 | | Descriptor: | GLUTATHIONE, GLYCEROL, Kunitz-type protease inhibitor 1, ... | | Authors: | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | Deposit date: | 2013-01-16 | | Release date: | 2013-03-06 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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4NTX
 | | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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5NX3
 | | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | | Deposit date: | 2017-05-09 | | Release date: | 2018-05-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.296 Å) | | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
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4ISO
 | | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | | Descriptor: | DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ... | | Authors: | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | | Deposit date: | 2013-01-16 | | Release date: | 2013-03-06 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
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4NTW
 | | Structure of acid-sensing ion channel in complex with snake toxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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4NTY
 | | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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3UOU
 | | Crystal structure of the Kunitz-type protease inhibitor ShPI-1 Lys13Leu mutant in complex with pancreatic elastase | | Descriptor: | Chymotrypsin-like elastase family member 1, GLYCEROL, Kunitz-type proteinase inhibitor SHPI-1, ... | | Authors: | Garcia-Fernandez, R, Perbandt, M, Rehders, D, Gonzalez-Gonzalez, Y, Chavez, M.A, Betzel, C, Redecke, L. | | Deposit date: | 2011-11-17 | | Release date: | 2012-11-21 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme.
J.Biol.Chem., 290, 2015
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4BD9
 | | Structure of the complex between SmCI and human carboxypeptidase A4 | | Descriptor: | CARBOXYPEPTIDASE A4, CARBOXYPEPTIDASE INHIBITOR SMCI, ZINC ION | | Authors: | Alonso-del-Ribero, M, Reytor, M.L, Trejo, S.A, Chavez, M.A, Aviles, F.X, Reverter, D. | | Deposit date: | 2012-10-05 | | Release date: | 2013-07-17 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A Noncanonical Mechanism of Carboxypeptidase Inhibition Revealed by the Crystal Structure of the Tri-Kunitz Smci in Complex with Human Cpa4.
Structure, 21, 2013
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3FP6
 | | Anionic trypsin in complex with bovine pancreatic trypsin inhibitor (BPTI) determined to the 1.49 A resolution limit | | Descriptor: | 1,2-ETHANEDIOL, Anionic trypsin-2, CALCIUM ION, ... | | Authors: | Zakharova, E, Horvath, M.P, Goldenberg, D.P. | | Deposit date: | 2009-01-04 | | Release date: | 2009-02-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structure of a serine protease poised to resynthesize a peptide bond.
Proc.Natl.Acad.Sci.USA, 106, 2009
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4BNR
 | | Extremely stable complex of crayfish trypsin with bovine trypsin inhibitor | | Descriptor: | CALCIUM ION, HEPATOPANCREAS TRYPSIN, PANCREATIC TRYPSIN INHIBITOR, ... | | Authors: | Molnar, T, Voros, J, Szeder, B, Takats, K, Kardos, J, Katona, G, Graf, L. | | Deposit date: | 2013-05-17 | | Release date: | 2013-09-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Comparison of Complexes Formed by a Crustacean and a Vertebrate Trypsin with Bovine Pancreatic Trypsin Inhibitor - the Key to Achieving Extreme Stability?
FEBS J., 280, 2013
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4DG4
 | | Human mesotrypsin-S39Y complexed with bovine pancreatic trypsin inhibitor (BPTI) | | Descriptor: | CALCIUM ION, PRSS3 protein, Pancreatic trypsin inhibitor, ... | | Authors: | Salameh, M.A, Soares, A.S, Radisky, E.S. | | Deposit date: | 2012-01-24 | | Release date: | 2012-09-12 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors.
Protein Sci., 21, 2012
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3OTJ
 | | A Crystal Structure of Trypsin Complexed with BPTI (Bovine Pancreatic Trypsin Inhibitor) by X-ray/Neutron Joint Refinement | | Descriptor: | CALCIUM ION, Cationic trypsin, Pancreatic trypsin inhibitor, ... | | Authors: | Kawamura, K, Yamada, T, Kurihara, K, Tamada, T, Kuroki, R, Tanaka, I, Takahashi, H, Niimura, N. | | Deposit date: | 2010-09-12 | | Release date: | 2011-01-26 | | Last modified: | 2024-10-16 | | Method: | NEUTRON DIFFRACTION (2.15 Å), X-RAY DIFFRACTION | | Cite: | X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex.
Acta Crystallogr.,Sect.D, 67, 2011
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3L33
 | | Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI) | | Descriptor: | Amyloid beta A4 protein, CALCIUM ION, FORMIC ACID, ... | | Authors: | Salameh, M.A, Soares, A.S, Radisky, E.S. | | Deposit date: | 2009-12-16 | | Release date: | 2010-09-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
J.Biol.Chem., 285, 2010
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3FP7
 | | Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) cleaved at the scissile bond (LYS15-ALA16) determined to the 1.46 A resolution limit | | Descriptor: | 1,2-ETHANEDIOL, Anionic trypsin-2, CALCIUM ION, ... | | Authors: | Zakharova, E, Horvath, M.P, Goldenberg, D.P. | | Deposit date: | 2009-01-04 | | Release date: | 2009-02-17 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structure of a serine protease poised to resynthesize a peptide bond.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3P95
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2ODY
 | | Thrombin-bound boophilin displays a functional and accessible reactive-site loop | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Boophilin, PHOSPHATE ION, ... | | Authors: | Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. | | Deposit date: | 2006-12-27 | | Release date: | 2008-01-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Isolation, cloning and structural characterisation of boophilin, a multifunctional kunitz-type proteinase inhibitor from the cattle tick.
Plos One, 3, 2008
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3FP8
 | | Anionic trypsin variant S195A in complex with bovine pancreatic trypsin inhibitor (BPTI) determined to the 1.46 A resolution limit | | Descriptor: | 1,2-ETHANEDIOL, Anionic trypsin-2, CALCIUM ION, ... | | Authors: | Zakharova, E, Horvath, M.P, Goldenberg, D.P, Curtice, K. | | Deposit date: | 2009-01-04 | | Release date: | 2009-02-17 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structure of a serine protease poised to resynthesize a peptide bond.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2PTC
 | | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | | Descriptor: | BETA-TRYPSIN, CALCIUM ION, TRYPSIN INHIBITOR | | Authors: | Huber, R, Deisenhofer, J. | | Deposit date: | 1982-09-27 | | Release date: | 1983-01-18 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
Acta Crystallogr.,Sect.B, 39, 1983
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3GYM
 | | Structure of Prostasin in Complex with Aprotinin | | Descriptor: | Pancreatic trypsin inhibitor, Prostasin | | Authors: | Spraggon, G, Hornsby, M, Shipway, A, Harris, J.L, Lesley, S.A. | | Deposit date: | 2009-04-03 | | Release date: | 2009-05-05 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein Sci., 18, 2009
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3P92
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2RA3
 | | Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) | | Descriptor: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | | Authors: | Salameh, M.A, Soares, A.S, Radisky, E.S. | | Deposit date: | 2007-09-14 | | Release date: | 2007-12-11 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
J.Biol.Chem., 283, 2008
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2R9P
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