8TD7
| Structure of PYCR1 complexed with 2S-hydroxy-3-methylbutyric acid | Descriptor: | (2S)-2-hydroxy-3-methylbutanoic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD2
| Structure of PYCR1 complexed with NADH and cyclobutane-1,1-dicarboxylic acid | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD3
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8TD8
| Structure of PYCR1 complexed with NADH and 2S-Hydroxy-3,3-dimethylbutyric acid | Descriptor: | (2S)-2-hydroxy-3,3-dimethylbutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TCX
| Structure of PYCR1 complexed with 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid | Descriptor: | 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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8TCV
| Structure of PYCR1 complexed with 4-bromobenzene-1,3-dicarboxylic acid | Descriptor: | 4-bromobenzene-1,3-dicarboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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6XP1
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8TD9
| Structure of PYCR1 complexed with NADH and L-pipecolic acid | Descriptor: | (2S)-piperidine-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD4
| Structure of PYCR1 complexed with NADH and 1,3-Dithiolane-2-carboxylic acid | Descriptor: | 1,3-dithiolane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TDC
| Structure of PYCR1 complexed with NADH and 1,3-dithiane-2-carboxylic acid | Descriptor: | 1,3-dithiane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD5
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8VRE
| Structure of PYCR1 complexed with NADH and N-formyl-L-proline | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-formyl-L-proline, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2024-01-21 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8DKG
| Structure of PYCR1 Thr171Met variant complexed with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Meeks, K.R, Tanner, J.J. | Deposit date: | 2022-07-05 | Release date: | 2023-02-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Functional Impact of a Cancer-Related Variant in Human Delta 1 -Pyrroline-5-Carboxylate Reductase 1. Acs Omega, 8, 2023
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5UAV
| Structure of human PYCR-1 complexed with NADPH and L-tetrahydrofuroic acid | Descriptor: | DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J. | Deposit date: | 2016-12-20 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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5UAX
| Structure of apo human PYCR-1 crystallized in space group C2 | Descriptor: | CHLORIDE ION, Pyrroline-5-carboxylate reductase 1, mitochondrial | Authors: | Tanner, J.J. | Deposit date: | 2016-12-20 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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5UAW
| Structure of apo human PYCR-1 crystallized in space group P21212 | Descriptor: | Pyrroline-5-carboxylate reductase 1, mitochondrial, SULFATE ION | Authors: | Tanner, J.J. | Deposit date: | 2016-12-20 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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8TD1
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5UAU
| Structure of human PYCR-1 complexed with proline | Descriptor: | PROLINE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J. | Deposit date: | 2016-12-20 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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8TDD
| Structure of PYCR1 complexed with NADH and 2-(furan-2-yl)acetic acid | Descriptor: | (furan-2-yl)acetic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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5UAT
| Structure of human PYCR-1 complexed with NADPH | Descriptor: | DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J. | Deposit date: | 2016-12-20 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. J. Biol. Chem., 292, 2017
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6XP3
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8TCW
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2IZZ
| Crystal structure of human pyrroline-5-carboxylate reductase | Descriptor: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRROLINE-5-CARBOXYLATE REDUCTASE 1 | Authors: | Pike, A.C.W, Guo, K, Kavanagh, K, Pilka, E.S, Berridge, G, Colebrook, S, Bray, J, Salah, E, Savitsky, P, Papagrigoriou, E, Turnbull, A.P, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Oppermann, U. | Deposit date: | 2006-07-31 | Release date: | 2006-08-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of Human Pyrroline-5-Carboxylate Reductase To be Published
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6XP0
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8TCY
| Structure of PYCR1 complexed with 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid | Descriptor: | 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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