8TD5

Structure of PYCR1 complexed with NADH and Tetrahydrothiophene-2-carboxylic acid

Summary for 8TD5

• Entry DOI: 10.2210/pdb8td5/pdb
• Descriptor: Pyrroline-5-carboxylate reductase 1, mitochondrial, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, (2R)-thiolane-2-carboxylic acid, ... (5 entities in total)
• Functional Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 5
• Total formula weight: 171939.17

Authors

Tanner, J.J.,Meeks, K.R. (deposition date: 2023-07-02, release date: 2024-07-03)

• Primary citation: Meeks, K.R.,Bogner, A.N.,Tanner, J.J.; Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1); Protein Sci., 33:-, 2024; DOI: 10.1002/pro.5072

Experimental method

X-RAY DIFFRACTION (1.81 Å)