6XP1
Structure of human PYCR1 complexed with L-thiazolidine-2-carboxylate
Summary for 6XP1
| Entry DOI | 10.2210/pdb6xp1/pdb |
| Descriptor | Pyrroline-5-carboxylate reductase 1, mitochondrial, (2S)-1,3-thiazolidine-2-carboxylic acid, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | amino-acid biosynthesis, oxidoreductase, proline biosynthesis |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 5 |
| Total formula weight | 170733.20 |
| Authors | Tanner, J.J.,Christensen, E.M. (deposition date: 2020-07-07, release date: 2020-11-04, Last modification date: 2023-10-18) |
| Primary citation | Christensen, E.M.,Bogner, A.N.,Vandekeere, A.,Tam, G.S.,Patel, S.M.,Becker, D.F.,Fendt, S.M.,Tanner, J.J. In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1. J.Biol.Chem., 295:18316-18327, 2020 Cited by PubMed: 33109600DOI: 10.1074/jbc.RA120.016106 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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