2ILK
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1ILK
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1LK3
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![BU of 1lk3 by Molmil](/molmil-images/mine/1lk3) | ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT | Descriptor: | 9D7 Heavy Chain, 9D7 Light Chain, Interleukin-10 | Authors: | Josephson, K, Jones, B.C, Walter, L.J, DiGiacomo, R, Indelicato, S.R, Walter, M.R. | Deposit date: | 2002-04-23 | Release date: | 2002-07-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography. Structure, 10, 2002
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1INR
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![BU of 1inr by Molmil](/molmil-images/mine/1inr) | CYTOKINE SYNTHESIS | Descriptor: | INTERLEUKIN-10 | Authors: | Walter, M.R. | Deposit date: | 1995-07-31 | Release date: | 1996-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry, 34, 1995
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2H24
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![BU of 2h24 by Molmil](/molmil-images/mine/2h24) | Crystal structure of human IL-10 | Descriptor: | Interleukin-10 | Authors: | Yoon, S.I, Walter, M.R. | Deposit date: | 2006-05-18 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J.Biol.Chem., 281, 2006
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8SVE
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1Y6K
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![BU of 1y6k by Molmil](/molmil-images/mine/1y6k) | Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain | Descriptor: | Interleukin-10, Interleukin-10 receptor alpha chain | Authors: | Yoon, S.I, Jones, B.C, Josepson, K, Logsdon, N.J, Walter, M.R. | Deposit date: | 2004-12-06 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure, 13, 2005
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1J7V
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![BU of 1j7v by Molmil](/molmil-images/mine/1j7v) | HUMAN IL-10 / IL-10R1 COMPLEX | Descriptor: | INTERLEUKIN-10, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN | Authors: | Josephson, K, Logsdon, N, Walter, M.R. | Deposit date: | 2001-05-18 | Release date: | 2001-09-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity, 15, 2001
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6X93
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![BU of 6x93 by Molmil](/molmil-images/mine/6x93) | Interleukin-10 signaling complex with IL-10RA and IL-10RB | Descriptor: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | Authors: | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | Deposit date: | 2020-06-02 | Release date: | 2021-03-17 | Last modified: | 2021-03-31 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science, 371, 2021
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