6RHV
 
 | | Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant) | | Descriptor: | Beta-channel forming cytolysin, DIMETHYL SULFOXIDE, Integrin alpha-M, ... | | Authors: | Trstenjak, N, Milic, D, Djinovic-Carugo, K, Badarau, A. | | Deposit date: | 2019-04-23 | | Release date: | 2019-12-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2LKJ
 | | Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails | | Descriptor: | Integrin alpha-M | | Authors: | Chua, G.L, Tang, X.Y, Amalraj, M, Tan, S.M, Bhattacharjya, S. | | Deposit date: | 2011-10-12 | | Release date: | 2011-11-02 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails
J.Biol.Chem., 2011
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7P2D
 | | Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jensen, R.K, Andersen, G.R. | | Deposit date: | 2021-07-05 | | Release date: | 2022-05-04 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural insights into the function-modulating effects of nanobody binding to the integrin receptor alpha M beta 2.
J.Biol.Chem., 298, 2022
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6RHW
 | | Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH | | Descriptor: | Beta-channel forming cytolysin, DIMETHYL SULFOXIDE, Integrin alpha-M, ... | | Authors: | Trstenjak, N, Milic, D, Djinovic-Carugo, K, Badarau, A. | | Deposit date: | 2019-04-23 | | Release date: | 2019-12-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7AKK
 | | Structure of a complement factor-receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | Authors: | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | | Deposit date: | 2020-10-01 | | Release date: | 2022-04-13 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.395 Å) | | Cite: | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
Nat Commun, 13, 2022
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4M76
 | | Integrin I domain of complement receptor 3 in complex with C3d | | Descriptor: | Complement C3, Integrin alpha-M, NICKEL (II) ION | | Authors: | Bajic, G, Yatime, L, Vorup-Jensen, T, Andersen, G.R. | | Deposit date: | 2013-08-12 | | Release date: | 2013-10-02 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4XW2
 | | Structural basis for simvastatin competitive antagonism of complement receptor 3 | | Descriptor: | Integrin alpha-M, MAGNESIUM ION, Simvastatin acid | | Authors: | Bajic, G, Jensen, M.R, Vorup-Jensen, T, Andersen, G.R. | | Deposit date: | 2015-01-28 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.
J.Biol.Chem., 291, 2016
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2LKE
 | | Structures and Interaction Analyses of the Integrin Alpha-M Beta-2 Cytoplasmic Tails | | Descriptor: | Integrin alpha-M | | Authors: | Chua, G.L, Tang, X.Y, Amalraj, M, Bhattacharjya, S, Tan, S.M. | | Deposit date: | 2011-10-11 | | Release date: | 2011-11-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structures and interaction analyses of the integrin alphaMbeta2 cytoplasmic tails
J.Biol.Chem., 2011
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1BHQ
 | | MAC-1 I DOMAIN CADMIUM COMPLEX | | Descriptor: | ACETYL GROUP, CADMIUM ION, CD11B | | Authors: | Baldwin, E.T. | | Deposit date: | 1998-06-10 | | Release date: | 1998-11-04 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cation binding to the integrin CD11b I domain and activation model assessment
Structure, 6, 1998
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1BHO
 | | MAC-1 I DOMAIN MAGNESIUM COMPLEX | | Descriptor: | CD11B, MAGNESIUM ION | | Authors: | Baldwin, E.T. | | Deposit date: | 1998-06-10 | | Release date: | 1998-11-04 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cation binding to the integrin CD11b I domain and activation model assessment
Structure, 6, 1998
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8VOI
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8VOH
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3QA3
 | | Crystal Structure of A-domain in complex with antibody | | Descriptor: | 1,2-ETHANEDIOL, Antibody Heavy chain, Antibody Light chain, ... | | Authors: | Mahalingam, B, Xiong, J.P, Arnaout, M.A. | | Deposit date: | 2011-01-10 | | Release date: | 2011-11-30 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design.
J.Immunol., 187, 2011
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8CE9
 | | Crystal structure of human Cd11b I domain in C121 space group | | Descriptor: | 1,2-ETHANEDIOL, Integrin alpha-M, SULFATE ION | | Authors: | Koekemoer, L, Williams, E, Ni, X, Gao, Q, Coker, J, MacLean, E.M, Wright, N.D, Marsden, B, Von Delft, F, Schwenzer, A, Midwood, K. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Crystal structure of human Cd11b I domain in C121 space group
To Be Published
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8CE6
 | | Crystal structure of human Cd11b I domain in P212121 space group | | Descriptor: | CHLORIDE ION, GLYCEROL, Integrin alpha-M, ... | | Authors: | Koekemoer, L, Williams, E, Ni, X, Gao, Q, Coker, J, MacLean, E.M, Wright, N.D, Marsden, B, Von Delft, F, Schwenzer, A, Midwood, K. | | Deposit date: | 2023-02-01 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.582 Å) | | Cite: | Crystal structure of human Cd11b I domain in P212121 space group
To Be Published
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1N9Z
 | | INTEGRIN ALPHA M I DOMAIN MUTANT | | Descriptor: | Integrin alpha-M, MAGNESIUM ION | | Authors: | McCleverty, C.J, Liddington, R.C. | | Deposit date: | 2002-11-26 | | Release date: | 2003-05-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
Biochem.J., 372, 2003
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1NA5
 | | INTEGRIN ALPHA M I DOMAIN | | Descriptor: | Integrin alpha-M | | Authors: | McCleverty, C.J, Liddington, R.C. | | Deposit date: | 2002-11-26 | | Release date: | 2003-05-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
Biochem.J., 372, 2003
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7USL
 | | Integrin alphaM/beta2 ectodomain in complex with adenylate cyclase toxin RTX751 and M1F5 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Goldsmith, J.A, McLellan, J.S. | | Deposit date: | 2022-04-25 | | Release date: | 2022-08-17 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
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7USM
 | | Integrin alphaM/beta2 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Goldsmith, J.A, McLellan, J.S. | | Deposit date: | 2022-04-25 | | Release date: | 2022-08-17 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
Cell Rep, 40, 2022
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3Q3G
 | | Crystal Structure of A-domain in complex with antibody | | Descriptor: | 1,2-ETHANEDIOL, Antibody Heavy chain, Antibody Light Chain, ... | | Authors: | Mahalingam, B, Xiong, J.P, Arnaout, M.A. | | Deposit date: | 2010-12-21 | | Release date: | 2011-11-30 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design.
J.Immunol., 187, 2011
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1IDO
 | | I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND | | Descriptor: | INTEGRIN, MAGNESIUM ION | | Authors: | Lee, J.-O, Liddington, R. | | Deposit date: | 1996-03-12 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).
Cell(Cambridge,Mass.), 80, 1995
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1JLM
 | | I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND | | Descriptor: | INTEGRIN, MANGANESE (II) ION | | Authors: | Lee, J.-O, Liddington, R. | | Deposit date: | 1996-04-09 | | Release date: | 1997-01-11 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Structure, 3, 1995
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1IDN
 | | MAC-1 I DOMAIN METAL FREE | | Descriptor: | CD11B | | Authors: | Baldwin, E.T. | | Deposit date: | 1998-06-10 | | Release date: | 1998-11-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cation binding to the integrin CD11b I domain and activation model assessment
Structure, 6, 1998
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1M1U
 | | AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN | | Descriptor: | CALCIUM ION, Integrin alpha-M | | Authors: | Xiong, J.-P, Li, R, Essafi, M, Stehle, T, Arnaout, M.A. | | Deposit date: | 2002-06-20 | | Release date: | 2002-08-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain.
J.Biol.Chem., 275, 2000
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1MF7
 | | INTEGRIN ALPHA M I DOMAIN | | Descriptor: | INTEGRIN ALPHA M | | Authors: | McCleverty, C.J, Liddington, R.C. | | Deposit date: | 2002-08-09 | | Release date: | 2003-05-20 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
Biochem.J., 372, 2003
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