4XW2

Structural basis for simvastatin competitive antagonism of complement receptor 3

Summary for 4XW2

Entry DOI	10.2210/pdb4xw2/pdb
Descriptor	Integrin alpha-M, MAGNESIUM ION, Simvastatin acid, ... (4 entities in total)
Functional Keywords	immune system, complement receptor 3, rossmann fold, integrin, statin, protein-inhibitor complex, mac-1, i domain, vwa
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P11215
Total number of polymer chains	1
Total formula weight	22941.48
Authors	Bajic, G.,Jensen, M.R.,Vorup-Jensen, T.,Andersen, G.R. (deposition date: 2015-01-28, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citation	Jensen, M.R.,Bajic, G.,Zhang, X.,Laustsen, A.K.,Kolds, H.,Skeby, K.K.,Schitt, B.,Andersen, G.R.,Vorup-Jensen, T. Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J.Biol.Chem., 291:16963-16976, 2016 Cited by PubMed: 27339893 DOI: 10.1074/jbc.M116.732222 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.001 Å)

Structure validation