4XW2
Structural basis for simvastatin competitive antagonism of complement receptor 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-M | polymer | 198 | 22480.6 | 1 | UniProt (P11215) Pfam (PF00092) | Homo sapiens (Human) | CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | Simvastatin acid | non-polymer | 436.6 | 1 | Chemie (SIM) | |||
| 4 | D (A) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 129 - 321 (UniProt: P11215)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | expression tag |
| Ala 125 | - | expression tag |
| Met 126 | - | expression tag |
| Gly 127 | - | expression tag |
| Ser 128 | - | expression tag |
| Gly 316 | Ile 332 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22480.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 460.9 | |
| All* | Total formula weight | 22941.5 |
