3S9D
 
 | | binary complex between IFNa2 and IFNAR2 | | Descriptor: | CHLORIDE ION, Interferon alpha-2, Interferon alpha/beta receptor 2 | | Authors: | Thomas, C, Garcia, K.C. | | Deposit date: | 2011-06-01 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9999 Å) | | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
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1RH2
 | | RECOMBINANT HUMAN INTERFERON-ALPHA 2B | | Descriptor: | INTERFERON-ALPHA 2B, ZINC ION | | Authors: | Walter, M.R. | | Deposit date: | 1996-11-07 | | Release date: | 1997-11-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Structure, 4, 1996
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4YPG
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4Z5R
 | | Rontalizumab Fab bound to Interferon-a2 | | Descriptor: | Interferon alpha-2, SULFATE ION, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ... | | Authors: | Eigenbrot, C, Maurer, B, Bosanac, I. | | Deposit date: | 2015-04-02 | | Release date: | 2015-07-08 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab.
Protein Sci., 24, 2015
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3SE3
 | | human IFNa2-IFNAR ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon alpha 2b, Interferon alpha/beta receptor 1, ... | | Authors: | Thomas, C, Garcia, K.C. | | Deposit date: | 2011-06-10 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (4.0001 Å) | | Cite: | Structural linkage between ligand discrimination and receptor activation by type I interferons.
Cell(Cambridge,Mass.), 146, 2011
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2LMS
 | | A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Interferon alpha-2 | | Authors: | Ghasriani, H, Belcourt, P.J.F, Sauve, S, Hodgson, D.J, Gingras, G, Brochu, D, Gilbert, M, Aubin, Y. | | Deposit date: | 2011-12-12 | | Release date: | 2012-12-05 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon alpha2a around the glycosylation site.
J.Biol.Chem., 288, 2013
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1ITF
 | | INTERFERON ALPHA-2A, NMR, 24 STRUCTURES | | Descriptor: | INTERFERON ALPHA-2A | | Authors: | Klaus, W, Gsell, B, Labhardt, A.M, Wipf, B, Senn, H. | | Deposit date: | 1997-08-22 | | Release date: | 1997-12-03 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.
J.Mol.Biol., 274, 1997
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2HYM
 | | NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human Interferon alpha-2 | | Descriptor: | Interferon alpha-2, Soluble IFN alpha/beta receptor | | Authors: | Quadt-Akabayov, S.R, Chill, J.H, Levy, R, Kessler, N, Anglister, J. | | Deposit date: | 2006-08-07 | | Release date: | 2006-10-10 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex
Protein Sci., 15, 2006
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2LAG
 | | Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained by 2D-double difference NOESY | | Descriptor: | Interferon alpha-2, Interferon alpha/beta receptor 2 | | Authors: | Nudelman, I, Akabayov, S.R, Scherf, T, Anglister, J. | | Deposit date: | 2011-03-13 | | Release date: | 2011-08-17 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Observation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon-Receptor Complex.
J.Am.Chem.Soc., 133, 2011
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2KZ1
 | | Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY | | Descriptor: | Interferon alpha-2, Soluble IFN alpha/beta receptor | | Authors: | Nudelman, I, Akabayov, S.R, Schnur, E, Biron, Z, Levy, R, Xu, Y, Yang, D, Anglister, J. | | Deposit date: | 2010-06-10 | | Release date: | 2010-06-23 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY
Biochemistry, 49, 2010
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