2LAG

Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained by 2D-double difference NOESY

Summary for 2LAG

• Entry DOI: 10.2210/pdb2lag/pdb
• Related: 1kz1
• NMR Information: BMRB: 16677
• Descriptor: Interferon alpha/beta receptor 2, Interferon alpha-2 (2 entities in total)
• Functional Keywords: interferon, receptor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P48551; Isoform 1: Membrane; Single-pass type I membrane protein. Isoform 2: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P01563
• Total number of polymer chains: 2
• Total formula weight: 43587.53

Authors

Nudelman, I.,Akabayov, S.R.,Scherf, T.,Anglister, J. (deposition date: 2011-03-13, release date: 2011-08-17, Last modification date: 2011-09-28)

• Primary citation: Nudelman, I.,Akabayov, S.R.,Scherf, T.,Anglister, J.; Observation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon-Receptor Complex.; J.Am.Chem.Soc., 133:14755-14764, 2011; PubMed: 21819146; DOI: 10.1021/ja205480v

Experimental method

SOLUTION NMR