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PDB: 11 results

1RTF
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COMPLEX OF BENZAMIDINE WITH THE CATALYTIC DOMAIN OF HUMAN TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR [(TC)-T-PA]
Descriptor: BENZAMIDINE, PHOSPHATE ION, TWO CHAIN TISSUE PLASMINOGEN ACTIVATOR
Authors:Bode, W, Lamba, D.
Deposit date:1995-11-10
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator
J.Mol.Biol., 258, 1996
1PML
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KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR KRINGLE 2
Authors:Padmanabhan, K, Tulinsky, A.
Deposit date:1994-04-25
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Kringle-kringle interactions in multimer kringle structures.
Protein Sci., 3, 1994
1TPK
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CRYSTAL STRUCTURE OF THE KRINGLE-2 DOMAIN OF TISSUE PLASMINOGEN ACTIVATOR AT 2.4-ANGSTROMS RESOLUTION
Descriptor: CHLORIDE ION, TISSUE PLASMINOGEN ACTIVATOR
Authors:De vos, A.M, Ultsch, M.H, Kelley, R.F, Padmanabhan, K, Tulinsky, A, Westbrook, M.L, Kossiakoff, A.A.
Deposit date:1991-09-24
Release date:1992-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Biochemistry, 31, 1992
1A5H
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CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE
Descriptor: 2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE, TISSUE PLASMINOGEN ACTIVATOR
Authors:Renatus, M, Bode, W, Stubbs, M.T.
Deposit date:1998-02-17
Release date:1999-04-20
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
J.Biol.Chem., 272, 1997
5BRR
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Michaelis complex of tPA-S195A:PAI-1
Descriptor: GLYCEROL, Plasminogen activator inhibitor 1, TRIETHYLENE GLYCOL, ...
Authors:Gong, L.
Deposit date:2015-06-01
Release date:2015-09-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
J.Biol.Chem., 290, 2015
1BDA
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CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)
Descriptor: N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide, SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR
Authors:Bode, W, Renatus, M, Engh, R.A.
Deposit date:1998-05-07
Release date:1999-05-11
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
EMBO J., 16, 1997
5ZLZ
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Structure of tPA and PAI-1
Descriptor: GLYCEROL, Plasminogen activator inhibitor 1, Tissue-type plasminogen activator
Authors:Min, L, Huang, M.
Deposit date:2018-03-31
Release date:2019-04-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.581 Å)
Cite:Development of a PAI-1 trapping agent (PAItrap2) based on inactivated tPA-SPD and the crystal structure of PAItrap2 in complex with PAI-1
To Be Published
1PK2
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SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN ACTIVATOR KRINGLE 2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG
Descriptor: 6-AMINOHEXANOIC ACID, TISSUE-TYPE PLASMINOGEN ACTIVATOR
Authors:Llinas, M, Byeon, I.-J.L.
Deposit date:1991-09-16
Release date:1994-01-31
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
J.Mol.Biol., 222, 1991
1TPN
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SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE
Descriptor: TISSUE-TYPE PLASMINOGEN ACTIVATOR
Authors:Downing, A.K, Driscoll, P.C, Harvey, T.S, Dudgeon, T.J, Smith, B.O, Baron, M, Campbell, I.D.
Deposit date:1993-05-26
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
J.Mol.Biol., 225, 1992
1TPG
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F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE)
Descriptor: T-PLASMINOGEN ACTIVATOR F1-G
Authors:Smith, B.O, Downing, A.K, Driscoll, P.C, Dudgeon, T.J, Campbell, I.D.
Deposit date:1995-06-14
Release date:1995-09-15
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator.
Structure, 3, 1995
1TPM
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SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE
Descriptor: TISSUE-TYPE PLASMINOGEN ACTIVATOR
Authors:Downing, A.K, Driscoll, P.C, Harvey, T.S, Dudgeon, T.J, Smith, B.O, Baron, M, Campbell, I.D.
Deposit date:1993-05-26
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
J.Mol.Biol., 225, 1992

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