1A5H
CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE
Summary for 1A5H
Entry DOI | 10.2210/pdb1a5h/pdb |
Descriptor | TISSUE PLASMINOGEN ACTIVATOR, 2,7-BIS-(4-AMIDINOBENZYLIDENE)-CYCLOHEPTAN-1-ONE, ... (4 entities in total) |
Functional Keywords | trypsin like serine protease, fibrinolytic enzyme, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 58750.69 |
Authors | Renatus, M.,Bode, W.,Stubbs, M.T. (deposition date: 1998-02-17, release date: 1999-04-20, Last modification date: 2023-08-02) |
Primary citation | Renatus, M.,Bode, W.,Huber, R.,Sturzebecher, J.,Prasa, D.,Fischer, S.,Kohnert, U.,Stubbs, M.T. Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors. J.Biol.Chem., 272:21713-21719, 1997 Cited by PubMed: 9268299DOI: 10.1074/jbc.272.35.21713 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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