8SCB
 
 | | Terminating ribosome with SRI-41315 | | Descriptor: | (2S,4aS)-2-cyclobutyl-10-methyl-3-phenyl-2,10-dihydropyrimido[4,5-b]quinoline-4,5(3H,4aH)-dione, 18S_rRNA, 28S_rRNA, ... | | Authors: | Yip, M.C.J, Coelho, J.P.L, Oltion, K, Tauton, J, Shao, S. | | Deposit date: | 2023-04-05 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structure and consequences of eRF1 glued to the ribosomal decoding center
To Be Published
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7JQB
 | | SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex | | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | | Authors: | Yuan, S, Xiong, Y. | | Deposit date: | 2020-08-10 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Mol.Cell, 80, 2020
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7UCK
 | | 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine | | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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7TOR
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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6YAL
 | | Mammalian 48S late-stage initiation complex with beta-globin mRNA | | Descriptor: | 18S ribosomal RNA, 40S Ribosomal protein uS3, 40S Ribosomal protein uS7, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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8P03
 | | 48S late-stage initiation complex with m6A mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | | Deposit date: | 2023-05-09 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
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6P5K
 | | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3) | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-30 | | Release date: | 2019-09-18 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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7TOQ
 | | Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | | Deposit date: | 2022-01-24 | | Release date: | 2022-05-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Nat Commun, 13, 2022
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7UCJ
 | | Mammalian 80S translation initiation complex with mRNA and Harringtonine | | Descriptor: | 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... | | Authors: | Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. | | Deposit date: | 2022-03-16 | | Release date: | 2022-06-01 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine.
Mol.Cell, 82, 2022
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6P5J
 | | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2) | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-30 | | Release date: | 2019-09-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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6P5I
 | | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-30 | | Release date: | 2019-09-18 | | Last modified: | 2020-02-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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6P4G
 | | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | | Descriptor: | 18S rRNA, IAPV-IRES, RACK1, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-27 | | Release date: | 2019-09-18 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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6P5N
 | | Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1 | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-30 | | Release date: | 2019-09-25 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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6D90
 | | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | | Descriptor: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | | Deposit date: | 2018-04-27 | | Release date: | 2018-06-06 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
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6P4H
 | | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2) | | Descriptor: | 18S rRNA, IAPV-IRES, RACK1, ... | | Authors: | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | Deposit date: | 2019-05-27 | | Release date: | 2019-09-18 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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7MDZ
 | | 80S rabbit ribosome stalled with benzamide-CHX | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ... | | Authors: | Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B. | | Deposit date: | 2021-04-06 | | Release date: | 2021-09-01 | | Last modified: | 2021-09-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.
J.Am.Chem.Soc., 143, 2021
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7JQC
 | | SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex | | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ... | | Authors: | Yuan, S, Xiong, Y. | | Deposit date: | 2020-08-10 | | Release date: | 2020-12-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Mol.Cell, 80, 2020
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8P09
 | | 48S late-stage initiation complex with non methylated mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | | Deposit date: | 2023-05-09 | | Release date: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
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6W2T
 | | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2) | | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | | Deposit date: | 2020-03-08 | | Release date: | 2020-04-22 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
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6W2S
 | | Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1) | | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | | Deposit date: | 2020-03-08 | | Release date: | 2020-04-22 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate.
Elife, 9, 2020
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6YAN
 | | Mammalian 48S late-stage translation initiation complex with histone 4 mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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7SYS
 | | Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII). | | Descriptor: | 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-27 | | Last modified: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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6YAM
 | | Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein eS10, ... | | Authors: | Bochler, A, Simonetti, A, Guca, E, Hashem, Y. | | Deposit date: | 2020-03-12 | | Release date: | 2020-04-08 | | Last modified: | 2020-04-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Insights into the Mammalian Late-Stage Initiation Complexes.
Cell Rep, 31, 2020
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7SYR
 | | Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt). | | Descriptor: | 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-27 | | Last modified: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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7SYX
 | | Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII) | | Descriptor: | 18S rRNA, 40S ribosomal protein S24, 40S ribosomal protein S25, ... | | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | | Deposit date: | 2021-11-25 | | Release date: | 2022-07-13 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
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