4YFU
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![BU of 4yfu by Molmil](/molmil-images/mine/4yfu) | |
6DSW
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![BU of 6dsw by Molmil](/molmil-images/mine/6dsw) | Bst DNA polymerase I pre-chemistry (n) structure | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*G)-3'), DNA (5'-D(P*AP*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.589 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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6MU4
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![BU of 6mu4 by Molmil](/molmil-images/mine/6mu4) | Bst DNA polymerase I FANA/DNA binary complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA polymerase I, ... | Authors: | Jackson, L.N, Chim, N, Chaput, J.C. | Deposit date: | 2018-10-22 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Nucleic Acids Res., 47, 2019
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7K5S
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![BU of 7k5s by Molmil](/molmil-images/mine/7k5s) | Bst DNA polymerase I time-resolved structure, 4 hr post dATP and dCTP addition | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(P*AP*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*C)-3'), DNA polymerase I, ... | Authors: | Chim, N, Meza, R.A, Trinh, A.M, Chaput, J.C. | Deposit date: | 2020-09-17 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun, 12, 2021
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4B9S
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![BU of 4b9s by Molmil](/molmil-images/mine/4b9s) | Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion outside of the pre-insertion site. | Descriptor: | 5'-D(*AP*CP*CP*TP*GP*AP*CP*TP*CP*TP)-3', 5'-D(*CP*AP*TP*FOXP*AP*GP*AP*GP*TP*CP*AP*GP*GP*TP*TP)-3', DNA POLYMERASE, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-06 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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4DWI
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![BU of 4dwi by Molmil](/molmil-images/mine/4dwi) | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with self complementary DNA, Se-dGTP and Calcium | Descriptor: | 9-METHYLGUANINE, CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), ... | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | Deposit date: | 2012-02-24 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
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6MU5
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![BU of 6mu5 by Molmil](/molmil-images/mine/6mu5) | Bst DNA polymerase I TNA/DNA binary complex | Descriptor: | DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA polymerase I, SULFATE ION, ... | Authors: | Jackson, L.N, Chim, N, Chaput, J.C. | Deposit date: | 2018-10-22 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.912 Å) | Cite: | Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase. Nucleic Acids Res., 47, 2019
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7K5P
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![BU of 7k5p by Molmil](/molmil-images/mine/7k5p) | Bst DNA polymerase I time-resolved structure, 4 min post dATP addition | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Meza, R.A, Trinh, A.M, Chaput, J.C. | Deposit date: | 2020-09-17 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun, 12, 2021
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6DSY
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![BU of 6dsy by Molmil](/molmil-images/mine/6dsy) | Bst DNA polymerase I post-chemistry (n+1) structure | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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6DSU
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![BU of 6dsu by Molmil](/molmil-images/mine/6dsu) | Bst DNA polymerase I pre-insertion complex structure | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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6DSV
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![BU of 6dsv by Molmil](/molmil-images/mine/6dsv) | Bst DNA polymerase I post-chemistry (n+2) structure | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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6DSX
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![BU of 6dsx by Molmil](/molmil-images/mine/6dsx) | Bst DNA polymerase I post-chemistry (n+1 with dATP soak) structure | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*TP*A)-3'), DNA (5'-D(*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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7K5U
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![BU of 7k5u by Molmil](/molmil-images/mine/7k5u) | Bst DNA polymerase I time-resolved structure, 48 hr post dATP and dCTP addition | Descriptor: | DNA (5'-D(P*CP*GP*AP*TP*CP*AP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*C)-3'), DNA polymerase I, ... | Authors: | Chim, N, Meza, R.A, Trinh, A.M, Chaput, J.C. | Deposit date: | 2020-09-17 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun, 12, 2021
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7K5Q
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![BU of 7k5q by Molmil](/molmil-images/mine/7k5q) | Bst DNA polymerase I time-resolved structure, 8 min post dATP addition | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*G*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), ... | Authors: | Chim, N, Meza, R.A, Trinh, A.M, Chaput, J.C. | Deposit date: | 2020-09-17 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun, 12, 2021
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4UQG
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![BU of 4uqg by Molmil](/molmil-images/mine/4uqg) | A new bio-isosteric base pair based on reversible bonding | Descriptor: | 5'-D(*AP*GP*GP*GP*A SAYP*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*C T0TP*TP*CP*CP*CP*TP)-3', DNA POLYMERASE, ... | Authors: | Tomas-Gamasa, M, Serdjukov, S, Su, M, Mueller, M, Carell, T. | Deposit date: | 2014-06-23 | Release date: | 2014-12-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | "Post-it" type connected DNA created with a reversible covalent cross-link. Angew. Chem. Int. Ed. Engl., 54, 2015
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4B9V
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![BU of 4b9v by Molmil](/molmil-images/mine/4b9v) | Structure of the high fidelity DNA polymerase I with extending from an oxidative formamidopyrimidine-dG DNA lesion -dA basepair. | Descriptor: | 5'-D(*CP*AP*TP*FOXP*AP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*TP*AP*AP)-3', DNA POLYMERASE, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-06 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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4B9M
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![BU of 4b9m by Molmil](/molmil-images/mine/4b9m) | Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dA DNA lesion -thymine basepair in the post- insertion site. | Descriptor: | 5'-D(*DC*DA*DA*FAX*AP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*TP*TP)-3', DNA POLYMERASE I, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-05 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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4B9L
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![BU of 4b9l by Molmil](/molmil-images/mine/4b9l) | Structure of the high fidelity DNA polymerase I with the oxidative formamidopyrimidine-dA DNA lesion in the pre-insertion site. | Descriptor: | 5'-D(*CP*AP*GP*FAX*AP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*TP)-3', DNA POLYMERASE I, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-05 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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4DSI
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![BU of 4dsi by Molmil](/molmil-images/mine/4dsi) | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, Se-dGTP and Calcium | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, CALCIUM ION, DNA, ... | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | Deposit date: | 2012-02-19 | Release date: | 2013-03-27 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
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4B9U
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![BU of 4b9u by Molmil](/molmil-images/mine/4b9u) | Structure of the high fidelity DNA polymerase I with an oxidative formamidopyrimidine-dG DNA lesion -dA basepair in the post-insertion site. | Descriptor: | 5'-D(*CP*AP*AP*FOXP*CP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*GP*AP)-3', DNA POLYMERASE, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-06 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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2Y1J
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![BU of 2y1j by Molmil](/molmil-images/mine/2y1j) | CRYSTAL STRUCTURE OF A R-DIASTEREOMER ANALOGUE OF THE SPORE PHOTOPRODUCT IN COMPLEX WITH FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS | Descriptor: | 5'-D(*AP*GP*GP*GP*QBTP*THM*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*AP*AP*CP*CP*CP*TP)-3', DNA POLYMERASE I, ... | Authors: | Heil, K, Schneider, S, Mueller, M, Kneuttinger, A.C, Carell, T. | Deposit date: | 2010-12-08 | Release date: | 2011-07-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the Uv-Induced Spore Photoproduct DNA Lesion. Chemistry, 17, 2011
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7K5O
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![BU of 7k5o by Molmil](/molmil-images/mine/7k5o) | Bst DNA polymerase I time-resolved structure, 1 min post dATP addition | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Meza, R.A, Trinh, A.M, Chaput, J.C. | Deposit date: | 2020-09-17 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Following replicative DNA synthesis by time-resolved X-ray crystallography. Nat Commun, 12, 2021
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4DSK
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![BU of 4dsk by Molmil](/molmil-images/mine/4dsk) | Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, PPi and Calcium | Descriptor: | CALCIUM ION, DNA (5'-D(*GP*GP*CP*TP*AP*CP*AP*GP*GP*AP*CP*TP*CP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*GP*AP*GP*TP*CP*CP*TP*GP*TP*AP*GP*CP*C)-3'), ... | Authors: | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | Deposit date: | 2012-02-19 | Release date: | 2013-03-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
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4B9N
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![BU of 4b9n by Molmil](/molmil-images/mine/4b9n) | Structure of the high fidelity DNA polymerase I correctly bypassing the oxidative formamidopyrimidine-dA DNA lesion. | Descriptor: | 5'-D(*CP*AP*AP*(FAX)*AP*GP*AP*GP*TP*CP*AP*GP*GP*CP*TP)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*TP*TP*TP*TP)-3', DNA POLYMERASE, ... | Authors: | Gehrke, T.H, Lischke, U, Arnold, S, Schneider, S, Carell, T. | Deposit date: | 2012-09-05 | Release date: | 2013-04-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. Nat.Chem.Biol., 9, 2013
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2XY5
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![BU of 2xy5 by Molmil](/molmil-images/mine/2xy5) | Crystal structure of an artificial salen-copper basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 5'-D(*AP*GP*GP*GP*AP*SAYP*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*SAYP*TP*CP*CP*CP*TP)-3', ... | Authors: | Kaul, C, Mueller, M, Wagner, M, Schneider, S, Carell, T. | Deposit date: | 2010-11-15 | Release date: | 2011-07-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Reversible Bond Formation Enables the Replication and Amplification of a Crosslinking Salen Complex as an Orthogonal Base Pair. Nature Chem., 3, 2011
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